Tooth whitening gel and preparation method thereof

A technology for tooth whitening and whitening gel is applied in the field of tooth whitening gel and its preparation, which can solve the problems of toothache for users, unsatisfactory actual effect, increase in cost and the like, achieve lasting anesthesia effect, relieve tooth pain and other discomforts Sensitivity, prevention of tooth sensitivity or pain

Pending Publication Date: 2022-04-08
青岛蓝皓生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, anti-sensitivity products can only be used separately from tooth whitening products, which is a separate solution to the problem of tooth sensitivity. If one or more of the above-mentioned substances are added to the tooth whitening gel formula, it will be damaged during the gel preparation process. In order to solve these difficulties, the cost will be greatly increased, and the actual effect is not ideal, and many users still have toothache and obvious discomfort.

Method used

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  • Tooth whitening gel and preparation method thereof
  • Tooth whitening gel and preparation method thereof
  • Tooth whitening gel and preparation method thereof

Examples

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preparation example Construction

[0053] In some embodiments, the preparation method of the cyclodextrin-included anti-sensitizer granules includes:

[0054] Mix the antisensitizer with the organic solvent according to the ratio of solid to liquid 1g: (2-4) ml to obtain solution A;

[0055] Mix cyclodextrin and water according to the material-to-liquid ratio of 1g:(4-6)ml to obtain solution B;

[0056] The solution A was mixed with the solution B, stirred and dried.

[0057] The organic solvent is preferably ethanol.

[0058] Specifically, the antisensitizer and the organic solvent can be 1g:2ml, 1g:2.1ml, 1g:2.2ml, 1g:2.3ml, 1g:2.4ml, 1g:2.5ml, 1g:2.6ml according to the ratio of material to liquid , 1g: 2.7ml, 1g: 2.8ml, 1g: 2.9ml, 1g: 3ml, 1g: 3.1ml, 1g: 3.2ml, 1g: 3.3ml, 1g: 3.4ml, 1g: 3.5ml, 1g: 3.6ml, 1g: 3.7ml, 1g: 3.8ml, 1g: 3.9ml, 1g: 4ml.

[0059] Cyclodextrin and water can be 1g:4ml, 1g:4.1ml, 1g:4.2ml, 1g:4.3ml, 1g:4.4ml, 1g:4.5ml, 1g:4.6ml, 1g:4.7ml, 1g: 4.8ml, 1g: 4.9ml, 1g: 5ml, 1g: 5.1ml, 1...

Embodiment 1

[0076] Preparation of Cyclodextrin-Included Benzocaine:

[0077] Dissolve 16g of benzocaine in 50mL of ethanol to obtain solution A, dissolve 98g of β-cyclodextrin in 500mL of purified water at 50°C to obtain solution B, and add solution A dropwise to solution B under constant stirring. Stir at 50°C for 2 hours, and dry to obtain cyclodextrin-included benzocaine.

[0078] Preparation of tooth whitening gel (reaction condition is 2-8°C water bath):

[0079] 1. Weigh 0.15 grams of xylitol, 3 grams of benzocaine clathrated with β-cyclodextrin, and 18 grams of disodium hydrogen phosphate and dissolve them in 30 grams of water to obtain solution C;

[0080] 2. Weigh 0.15 g of menthol and add 9 g of glycerin, stir evenly to obtain solution D;

[0081] 3. Add solution A to solution B, stir and mix evenly, add 6 grams of carbomer and stir (600r / min, 60min) until the carbomer is completely dissolved to obtain solution E;

[0082] 4. Add 170 grams of hydrogen peroxide (with a hydroge...

Embodiment 2

[0104] Preparation of Cyclodextrin-Included Benzocaine:

[0105] Dissolve 20g of benzocaine in 50mL of ethanol to obtain solution A, dissolve 49g of methyl β-cyclodextrin in 500mL of 50°C purified water to obtain solution B, and add solution A dropwise to solution B under constant stirring , Stir at 50°C for 2h, and dry to obtain methyl β-cyclodextrin inclusion benzocaine.

[0106] Preparation of tooth whitening gel (reaction condition is 2-8°C water bath):

[0107] 1. Weigh 0.15 grams of xylitol, 6 grams of cyclodextrin-included benzocaine, and 9 grams of sodium hydroxide and dissolve them in 30 grams of water to obtain solution C;

[0108] 2. Weigh 0.15 g of menthol and add 18 g of propylene glycol, stir evenly to obtain solution D;

[0109] 3. Add solution A to solution B, stir and mix evenly, add 9 grams of poloxamer and stir (600r / min, 60min) until completely dissolved to obtain solution E;

[0110] 4. Add 70 grams of carbamide peroxide and 157.5 grams of water to solu...

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Abstract

The invention discloses a tooth whitening gel containing an anti-allergy agent, the tooth whitening gel comprises solvent water and a pH regulator, and further comprises 1%-50% of an oxidizing agent, 0.1%-10% of a thickening agent and 0.1%-40% of cyclodextrin included anti-allergy agent particles, and the anti-allergy agent is selected from one or more of benzocaine, lidocaine, articaine, dyclonine, tetracaine, ropivacaine and eticaine. The invention also discloses a preparation method of the tooth whitening gel containing the anti-allergic agent. According to the invention, the anti-allergy agent is added into the tooth whitening agent and is clathrated by cyclodextrin, so that the anti-allergy agent is prevented from being oxidized by an oxidizing agent, and the tooth whitening agent has the effect of preventing tooth sensitivity or pain. In the using process, saliva secreted by the oral cavity of a user can decompose cyclodextrin and release the anti-allergy agent in the saliva, the anti-allergy agent is combined with a lipid layer of an oral mucosa at the gingival position, the local anesthesia and analgesia effects are achieved, particularly, stimulation of a high-concentration oxidizing agent to the oral cavity and teeth can be obviously improved, and tooth pain and other discomforts of the user are relieved.

Description

technical field [0001] The invention relates to the technical field of tooth whitening, in particular to a tooth whitening gel and a preparation method thereof. Background technique [0002] With the progress of society and the improvement of people's living standards, tooth whitening has gradually become a basic requirement for people to pursue a high-quality life. High-concentration hydrogen peroxide solution and its products are currently commonly used bleaching agents for tooth whitening in clinics, which can be quickly and safely bleached teeth. Tooth whitening agents containing high concentrations of hydrogen peroxide can cause many side effects on teeth and oral cavity, such as stimulating periodontal soft tissue, causing tooth sensitivity, tooth pain, etc. [0003] There are two conventional solutions to tooth sensitivity and pain: one is to add potassium salts, strontium salts, zinc salts, fluoride salts and other agents so that the nerves are not stimulated or gre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/44A61K8/73A61K8/22A61K8/38A61Q11/00A61P29/00A61P23/02A61P1/02
Inventor 陈德夫孙敬超
Owner 青岛蓝皓生物技术有限公司
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