Hydrophilic antibacterial glass slide with bionic structure and preparation method of hydrophilic antibacterial glass slide

A glass slide and hydrophilic technology, applied in the field of antibacterial materials, to achieve good sterilization effect, low price and strong practicability

Pending Publication Date: 2022-03-18
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is just to provide a kind of biomimetic structure, the synergistic antibacterial mechanism of quaternary ammonium salt a kind of structured biomimetic hydrophilic antibacterial medical glass slide, also provide a kind of preparation method of biomimetic structure hydrophilic antibacterial glass slide, to solve Slides can be quickly sterilized and resistant to staining detection

Method used

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  • Hydrophilic antibacterial glass slide with bionic structure and preparation method of hydrophilic antibacterial glass slide
  • Hydrophilic antibacterial glass slide with bionic structure and preparation method of hydrophilic antibacterial glass slide
  • Hydrophilic antibacterial glass slide with bionic structure and preparation method of hydrophilic antibacterial glass slide

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preparation example Construction

[0033] The biomimetic structure hydrophilic antibacterial glass slide of the present invention uses laser etching to prepare a large-area bionic micro-nano protrusion structure on the surface of the glass slide, and the surface is pretreated by a silane coupling agent through plasma or piranha solution. A copolymer of quaternary ammonium salts is covalently attached to the surface of a glass slide. The preparation method of the bionic structure hydrophilic antibacterial glass slide of the present invention comprises the following steps:

[0034] Ⅰ. Etching the bionic micro-nano structure on the surface of the glass slide with a laser: laser processing the surface of the slide glass with a laser engraving machine;

[0035] Ⅱ. Treat the biomimetic structure slide with piranha solution or plasma to make its surface contain a large amount of hydroxyl groups: prepare the slide, perform surface pretreatment and functionalization on the slide;

[0036] III. In the aqueous solution, ...

Embodiment 1

[0047] A method for preparing a bionic structure hydrophilic antibacterial glass slide, comprising the steps of:

[0048] Ⅰ. Preparation of the micro-nano structure on the surface of the glass slide: use a laser engraving machine to perform laser processing on the surface of the glass slide, the laser energy intensity is 500w, and the scanning speed is 500mm / s;

[0049] Ⅱ. Slide pretreatment: H 2 SO 4 and H 2 o 2 Prepare the piranha solution with a volume ratio of 3:2, put the prepared biomimetic structured glass slide into the piranha solution and etch for 15 minutes, wash with water three times after the reaction, and dry with N2 to make the surface of the slide hydroxylated;

[0050] Ⅲ. Coating of silane coupling agent: add 3-aminopropyltrimethoxysilane as a silane coupling agent into water to disperse, so that its concentration is 7.5wt% aqueous solution, and then put the mixed solution into an ultrasonic disperser Sonicate for 30 minutes, then put the hydroxylated gla...

Embodiment 2

[0054] A method for preparing a bionic structure hydrophilic antibacterial glass slide, comprising the steps of:

[0055] Ⅰ. Preparation of the micro-nano structure on the surface of the glass slide: use a laser engraving machine to carry out laser processing on the surface of the glass slide, the laser energy intensity is 300w, and the scanning speed is 400mm / s;

[0056] Ⅱ. Slide pretreatment: put the prepared slide into the piranha solution for etching for 15 minutes, wash with water three times after the reaction, and dry with N2 to make the surface of the slide hydroxylated;

[0057] Ⅲ. Coating of silane coupling agent: Add 3-aminopropyltrimethoxysilane as a silane coupling agent into water to disperse, so that its concentration is 12.5wt% aqueous solution, and then put the mixture into an ultrasonic disperser Sonicate for 30 minutes, then put the hydroxylated glass slide into the mixture, react at 80°C for 8 hours, then take it out and wash with water to remove unreacted ...

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Abstract

The invention relates to a hydrophilic antibacterial glass slide with a bionic structure and a preparation method of the hydrophilic antibacterial glass slide. The preparation method comprises the following steps: etching a bionic micro-nano structure on the surface of the glass slide by using laser; processing the biomimetic structure glass slide with a piranha solution or plasma to enable the surface of the biomimetic structure glass slide to contain a large number of hydroxyl groups; the method comprises the following steps: hydrolyzing a silane coupling agent in an aqueous solution, and coating the silane coupling agent on the surface of a bionic structure glass slide through chemical reaction; the bionic structure glass slide containing the silane coupling agent is soaked in an aqueous solution containing quaternary ammonium salt for quaternization treatment. The method for preparing the hydrophilic antibacterial glass slide with the bionic structure is carried out in a water phase system, and an organic solvent is not needed; the structured bionic hydrophilic antibacterial glass slide prepared by the invention is combined with the organic coating through covalent bonds and is not easily damaged by the outside; the hydrophilic antibacterial glass slide with the bionic structure prepared by the invention has excellent antibacterial performance.

Description

technical field [0001] The invention belongs to the technical field of antibacterial materials, and in particular relates to a hydrophilic antibacterial glass slide with a bionic structure and a preparation method thereof. Background technique [0002] For a long time, infectious diseases caused by bacterial infection have greatly endangered people's healthy life. With the advancement of the times and the rapid development of science and technology, the medical detection technologies related to infectious diseases are becoming more and more mature. The detection technologies include staining microscopy, Xpert MTB / RIF, TB-DNA PCR and T-SPOT.TB, etc. Among them, the most common detection method is staining microscope inspection, which is a detection method in which the sample is applied to a glass slide, sterilized by ultraviolet light, stained, and finally obtained by microscope inspection. The glass slide used in the test is a type of super-hydrophilic glass slide, which do...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G02B21/34B23K26/354C03C17/30
CPCG02B21/34C03C17/30B23K26/354
Inventor 刘燕方正平郭志敏李淑一范玉艳何浩会
Owner JILIN UNIV
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