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Multifunctional guided bone regeneration composite membrane as well as preparation method and application thereof

A guided bone regeneration and multifunctional technology, applied in the field of medical materials, can solve the problems of reducing the quality of life of patients and affecting the effect of periodontal tissue health and denture restoration, and achieve good cell compatibility, anti-bacterial adhesion, and antibacterial timeliness Promoted effect

Active Publication Date: 2022-03-15
HOSPITAL OF STOMATOLOGY SUN YAT SEN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002]Alveolar bone defect caused by trauma, tumor resection, congenital disease, periodontal disease, etc. is a common and frequently-occurring clinical disease, which will greatly affect the dental Peripheral tissue health and the effect of denture restoration, especially the effect of implant denture restoration, greatly reduce the quality of life of patients

Method used

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  • Multifunctional guided bone regeneration composite membrane as well as preparation method and application thereof
  • Multifunctional guided bone regeneration composite membrane as well as preparation method and application thereof
  • Multifunctional guided bone regeneration composite membrane as well as preparation method and application thereof

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Effect test

Embodiment 1

[0042] Embodiment 1, the preparation method of a kind of multifunctional guided bone regeneration composite film

[0043] A preparation method of a multifunctional guided bone regeneration composite film, comprising the following steps:

[0044] S1. Take a square bacterial cellulose film with a side length of 2 cm and a thickness of 1 mm, stir and wash it with double distilled water for 20 minutes, and dry it;

[0045] S2. Take 10 pieces of dried bacterial cellulose membranes and place them in 100mL 75% ethanol solution, pass nitrogen gas for 0.5h to remove oxygen, then add 3mL acetic acid and 1.5mL silane coupling agent KH570 and stir at room temperature for 0.5h, then place Heat and stir at 70°C for 3 hours, then rinse the product three times with absolute ethanol and once with pure water to obtain a double bond modified bacterial cellulose membrane;

[0046] S3. Place the double bond modified bacterial cellulose membrane in 80mL of pure water, pass nitrogen gas for 0.5h to...

Embodiment 2

[0049] Embodiment 2, the preparation method of a kind of multifunctional guided bone regeneration composite film

[0050] A preparation method of a multifunctional guided bone regeneration composite film, comprising the following steps:

[0051] S1. Take a square bacterial cellulose film with a side length of 2 cm and a thickness of 1 mm, stir and wash it with double distilled water for 20 minutes, and dry it;

[0052] S2. Take 10 pieces of dried bacterial cellulose membranes and place them in 100mL 75% ethanol solution, pass nitrogen gas for 0.5h to remove oxygen, then add 3mL acetic acid and 1.5mL silane coupling agent KH570 and stir at room temperature for 0.5h, then place Heat and stir at 70°C for 2.5 hours, then rinse the product three times with absolute ethanol and once with pure water to obtain a double bond modified bacterial cellulose membrane;

[0053] S3. Place the double bond modified bacterial cellulose membrane in 80mL of pure water, pass nitrogen gas for 0.5h ...

Embodiment 3

[0056] Embodiment 3, the preparation method of a kind of multifunctional guided bone regeneration composite film

[0057] A preparation method of a multifunctional guided bone regeneration composite film, comprising the following steps:

[0058] S1. Take a square bacterial cellulose film with a side length of 2 cm and a thickness of 1 mm, stir and wash it with double distilled water for 20 minutes, and dry it;

[0059] S2. Take 10 pieces of dried bacterial cellulose membranes and place them in 100mL75% ethanol solution, pass nitrogen gas for 0.5h to remove oxygen, then add 3mL acetic acid and 1.5mL silane coupling agent KH570 and stir at room temperature for 0.5h, then place at 75 Heating and stirring at ℃ for 3.5 hours, then washing the product three times with absolute ethanol and once with pure water to obtain a double bond modified bacterial cellulose membrane;

[0060] S3. Place the double bond modified bacterial cellulose membrane in 80mL of pure water, pass nitrogen ga...

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Abstract

The invention relates to the field of medical materials, and particularly discloses a multifunctional guided bone regeneration composite membrane and a preparation method and application thereof.The method comprises the steps that S1, a bacterial cellulose membrane is placed in an ethanol solution, acetic acid and a silane coupling agent are added, and a double-bond modified bacterial cellulose membrane is obtained; s2, putting the double-bond modified bacterial cellulose membrane into pure water, adding an acrylamide monomer and a potassium persulfate initiator, and heating and stirring to obtain a polyacrylamide grafted bacterial cellulose membrane; s3, soaking the polyacrylamide grafted bacterial cellulose membrane in a sodium hypochlorite solution to obtain an N-halamine modified bacterial cellulose compact layer; and S4, adding a glutaraldehyde aqueous solution into the chitosan-hydroxyapatite dispersion liquid, stirring and cross-linking to obtain a mixed dispersion liquid, coating the compact layer with the mixed dispersion liquid, and freeze-drying to obtain the chitosan-hydroxyapatite composite material. The composite membrane provided by the invention has the advantages of excellent barrier effect, antibacterial property and osteogenesis promoting function, and improves the success rate of guided bone regeneration and repair.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a multifunctional guiding bone regeneration composite film and its preparation method and application. Background technique [0002] Alveolar bone defects caused by trauma, tumor resection, congenital diseases, periodontal diseases, etc. are common clinical and frequently-occurring diseases, which will greatly affect the health of periodontal tissue and the effect of denture restoration, especially the effect of implant denture restoration , greatly reducing the patient's quality of life. Guided bone regeneration is a reliable method to solve the lack of alveolar bone in clinical practice. It has been widely used in the fields of alveolar surgery, periodontal and oral implant restoration. The isolation barrier selectively blocks the faster-growing epithelial cells and fibroblasts from the defect, allowing the slower-growing bone tissue to complete repair and regenerati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/12A61L31/04A61L31/02A61L31/14A61L31/16C08J7/16C08J7/12C08J7/14C08J7/04C08L1/02
CPCA61L31/042A61L31/048A61L31/028A61L31/14A61L31/146A61L31/16C08J7/12C08J7/16C08J7/14C08J7/0427C08J2301/02C08J2405/08A61L2300/232A61L2300/404C08L1/02C08L5/08C08L33/26
Inventor 吴淑仪李彦吴丁财罗舒璐岑宗恒周铭洪李倩倩何汶懿
Owner HOSPITAL OF STOMATOLOGY SUN YAT SEN UNIV
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