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Drug balloon and preparation method thereof

A technology of balloons and drugs, which is applied in drug delivery, pharmaceutical formulations, catheters, etc., can solve the problems of weakened balloon lubricity, large molecular weight of PVP, and unfavorable drug bioavailability, so as to reduce adsorption, reduce losses, and improve The effect of bioavailability

Pending Publication Date: 2022-03-15
禾木(中国)生物工程有限公司
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Problems solved by technology

[0007] The disadvantages of this structure are as follows: First, only a single component such as PVP or PEG is used. Although the lubricity of the balloon can be improved to a certain extent, as the balloon is transferred in the blood vessel, the PVP is gradually lost, making the balloon The lubricity of the capsule is weakened; the second is that the molecular weight of PVP is large, and after entering the lesion blood vessel, the large molecular weight is not conducive to the bioavailability of the drug

Method used

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  • Drug balloon and preparation method thereof
  • Drug balloon and preparation method thereof
  • Drug balloon and preparation method thereof

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Embodiment Construction

[0040] The present invention will be described below in conjunction with the accompanying drawings and embodiments.

[0041] A drug balloon, comprising a balloon body, the outer surface of the balloon body is coated with a drug coating, the drug coating includes a first component and a second component, the first component includes polyvinylpyrrolidone (PVP), polyethylene glycol (PEG), a photoinitiator and a first solvent, the second component includes a cell proliferation inhibitory drug, a drug carrier and a second solvent, and the drug carrier is amphiphilic One or more polymer compounds.

[0042] According to the clinical application of the drug balloon, it is determined that the balloon body should be able to be transferred to the lesion in the tortuous blood vessel, and the drug coating should be absorbed by the tissue as soon as possible to improve the bioavailability. There will be a large amount of drug loss during the delivery process in the body, some will be left ...

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Abstract

The invention discloses a drug balloon which comprises a balloon body, the outer surface of the balloon body is coated with a drug coating, the drug coating comprises a first component and a second component, the first component comprises polyvinylpyrrolidone (PVP), polyethylene glycol (PEG), a photoinitiator and a first solvent, and the second component comprises a second solvent and a third solvent. The second component comprises a cell proliferation inhibition drug, a drug carrier and a second solvent; the cell proliferation inhibition drug is one or more of rapamycin, rapamycin and derivatives thereof, paclitaxel and derivatives thereof, the drug carrier is one or more of amphipathic high-molecular compounds, the balloon has the advantages of being good in balloon lubricity, low in drug delivery loss rate, high in bioavailability and the like, and compared with other similar products, the balloon has the advantages of being good in balloon lubricity, low in drug delivery loss rate, high in bioavailability and the like. The medicine is more suitable for patients with intracranial atherosclerosis with high intracranial blood vessel tortuosity degree and small narrow blood vessel diameter, and has a remarkable curative effect.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a drug balloon and a preparation method thereof. Background technique [0002] Drug balloons are commonly used in the treatment of cardiovascular diseases, which can inhibit the proliferation of dilated vascular smooth muscle cells and prevent restenosis after vasodilatation. Drug balloons have obvious curative effects in interventional therapy. [0003] The drug coating is coated on the surface of the balloon, and the drug balloon is delivered to the lesion site through the catheter. The balloon is inflated in the blood vessel, and the inflation time of the balloon is short. It is necessary to ensure that the drug coating is transferred to the vessel wall during the inflation period of the balloon. And it can effectively release the drug and improve the absorption of water-insoluble therapeutic agents; at the same time, it must ensure the integrity of the drug coating du...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L29/16A61L29/08A61L29/14
CPCA61L29/16A61L29/085A61L29/14A61L2300/606A61L2300/416A61L2400/10A61L2300/802C08L71/02C08L39/06
Inventor 于得水张新波孔令涛宋冬辉林彦廷李波王吉成
Owner 禾木(中国)生物工程有限公司
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