Bioabsorbable orthopedic implant material and preparation method thereof

A technology for bioabsorption and implantation of materials, applied in the field of biomedical materials, can solve problems such as insufficient mechanical properties, and achieve the effects of good designability, good biocompatibility, and good damage resistance.

Active Publication Date: 2022-03-01
BEIHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, collagen, polylactic acid and polycaprolactone alone have the problem of insufficient mechanical properties of bone implant materials made of bioabsorbable medical polymers

Method used

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  • Bioabsorbable orthopedic implant material and preparation method thereof
  • Bioabsorbable orthopedic implant material and preparation method thereof
  • Bioabsorbable orthopedic implant material and preparation method thereof

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preparation example Construction

[0043] The present invention also provides a preparation method of the bioabsorbable orthopedic implant material described in the above technical solution, comprising the following steps:

[0044] The two-dimensional silk fiber fabric and the bioabsorbable polymer material film are laminated, and the first melting and the first prepressing are performed in sequence to obtain the bioabsorbable orthopedic implant material.

[0045] In the present invention, the thickness of the bioabsorbable polymer material film is preferably 0.07mm-0.18mm. In the present invention, before forming the bioabsorbable polymer material film, it is preferable to further include drying the bioabsorbable polymer material; the present invention does not limit the conditions for drying the bioabsorbable polymer material, It is sufficient as long as the bioabsorbable polymer material can be dried.

[0046] In the present invention, the two-dimensional silk fiber fabric is preferably pretreated before us...

Embodiment 1

[0079] A silk fiber-reinforced bioabsorbable orthopedic implant material: using silk fiber as a reinforcing phase and bioabsorbable polymer material polylactic acid as a matrix phase, it is prepared according to the following steps:

[0080] (1) Modification of silk fiber non-woven fabric

[0081] Dissolving γ-aminopropyltriethoxysilane in an ethanol solution is configured as a coupling agent solution, and in the coupling agent solution, the volume fraction of the coupling agent γ-aminopropyltriethoxysilane is 3%; Surface density is 60g / m 2 Put the artificial silk fiber non-woven fabric into the prepared coupling agent solution and let it stand at room temperature for 30 minutes; clean it with deionized water ultrasonically, soak it in medical alcohol for disinfection, and dry it in vacuum at 60°C for 24 hours to obtain improved Sexual silk fiber non-woven fabric.

[0082] (2) Preparation of prepreg

[0083] Polylactic acid (PLA) was vacuum-dried at 80°C for 24 hours and ma...

Embodiment 2

[0089] A silk fiber-reinforced bioabsorbable orthopedic implant material: using silk fiber as a reinforcement and bioabsorbable polymer material polycaprolactone as a matrix phase, it is prepared according to the following steps:

[0090] (1) Preparation of prepreg

[0091] Polycaprolactone (PCL) was vacuum-dried at 40°C for 48 hours and made into a film with a thickness of 0.7mm; the surface density was 90g / m 2 The two-dimensional plain weave fabric of mulberry silk was ultrasonically cleaned in deionized water, then soaked in medical alcohol for disinfection, and dried in vacuum at 60°C for 24 hours; a layer of two-dimensional plain weave silk fabric was placed in a rigid mold. Underneath the above layer of polycaprolactone film, preheat at 130°C for 5 minutes, apply a pressure of 5 MPa with a hot press, and keep the pressure for 3 minutes, so that the polycaprolactone is melted above the melting point and fully contacted and infiltrated with silk. After cooling, it is shape...

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Abstract

The invention belongs to the technical field of biomedical materials, and provides a bioabsorbable orthopedic implant material and a preparation method thereof. The silk fiber serving as a reinforcing phase has the advantages of light weight, high strength, good designability, fatigue resistance and good damage resistance, and the defect that a bioabsorbable high polymer material is insufficient in mechanics or easy to break in a body can be overcome; meanwhile, the silk fibers are completely formed by polymerizing amino acid, degradation products of the silk fibers are also amino acid and have good biocompatibility, the degradation rate is low, and the too high degradation rate of the bioabsorbable high polymer material can be slowed down; and due to the use of the bioabsorbable high polymer material, the property that the bioabsorbable orthopedic implant material is integrally absorbable in vivo can be continuously kept. The bioabsorbable orthopedic implant material is good in biocompatibility, the mechanical property of the bioabsorbable orthopedic implant material is matched with that of bones, the bioabsorbable orthopedic implant material can be fully degraded in a human body, and the degradation rate of the bioabsorbable orthopedic implant material can be regulated and controlled within a certain range.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a bioabsorbable orthopedic implant material and a preparation method thereof. Background technique [0002] Bone implant materials play an indispensable role in the treatment of orthopedic diseases, and play an important role in helping to cure bone diseases or promoting tissue healing. [0003] There are mainly three types of bone implant materials commonly used in clinical practice: metal materials, non-bioabsorbable polymer-based materials, and bioabsorbable medical polymer-based materials. Metal materials were first used clinically. The most representative metal material is titanium alloy. Titanium alloy has the advantages of good corrosion resistance, compression resistance and biocompatibility, but it does not have osteoconductivity, and bone tissue cannot grow. Into the interior can only be attached to the surface. The Young's modulus of human cortical bone ...

Claims

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Application Information

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IPC IPC(8): A61L31/14A61L31/04A61L31/06A61L31/12A61L27/22A61L27/18A61L27/58A61L27/50A61L27/40
CPCA61L31/148A61L31/14A61L31/047A61L31/06A61L31/042A61L27/227A61L27/18A61L27/58A61L27/50A61L2430/02A61L2430/38A61L2430/12C08L89/00C08L67/04C08L67/02C08L75/04C08L5/08C08L5/04C08L67/00
Inventor 管娟田文晗刘玉增
Owner BEIHANG UNIV
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