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Phase-change material particle-loaded fiber wound repair stent as well as preparation method and application thereof

A technology for phase change materials and wound repair, which is applied in fiber processing, textiles, papermaking, bandages, etc. It can solve the problems of unable to adjust the timing and on-demand release of functional substances such as bioactive factors and antibacterial drugs, and achieve biodegradable performance Good, good biocompatibility, promotes recruitment and migration

Active Publication Date: 2022-03-01
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The current research on scaffold materials based on electrospinning mainly focuses on blending or post-processing antibacterial drugs and growth factors with electrospun nanofiber membranes. Most of the scaffolds obtained are simple composite scaffolds. Unable to adjust the timing and on-demand release of functional substances such as bioactive factors and antibacterial drugs

Method used

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  • Phase-change material particle-loaded fiber wound repair stent as well as preparation method and application thereof
  • Phase-change material particle-loaded fiber wound repair stent as well as preparation method and application thereof
  • Phase-change material particle-loaded fiber wound repair stent as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] Prepare the solution:

[0074] Take metronidazole and add it to N,N-dimethylformamide, fully stir and ultrasonically dissolve it to obtain its saturated solution A;

[0075] Take chlorhexidine acetate and add it to trifluoroethanol, fully stir and ultrasonically dissolve it to obtain its saturated solution B;

[0076] Dissolve polycaprolactone in dichloromethane, and magnetically stir at room temperature for 12 hours to obtain a solution C1 with a mass concentration of 6%;

[0077] Dissolve polylactic acid in trifluoroethanol, and magnetically stir at room temperature for 12 hours to obtain a solution C2 with a mass concentration of 6%;

[0078] Dissolving dodecanoic acid and octadecanoic acid in a mixed solution of ethanol and dichloromethane with a volume ratio of 2:8 at a mass ratio of 8:2, ultrasonicated for 10 minutes to obtain a solution F with a mass concentration of 20%;

[0079] Take recombinant human platelet-derived growth factor-BB and add it into sterile ...

Embodiment 2

[0088] Prepare the solution:

[0089] Take metronidazole and add it to trifluoroethanol, fully stir and ultrasonically dissolve it to obtain its saturated solution A;

[0090] Take tetracycline hydrochloride and add it to hexafluoroisopropanol, fully stir and ultrasonically dissolve it to obtain its saturated solution B;

[0091] Take polycaprolactone granules and gelatin powder at a mass ratio of 60:40, dissolve them in trifluoroethanol respectively, and stir magnetically at room temperature for 12 hours to obtain a uniform polycaprolactone solution and gelatin solution, mix the two solutions and stir for 6 hours A solution C1 with a mass concentration of 6% was obtained;

[0092] Dissolve polycaprolactone in trifluoroethanol and magnetically stir at room temperature for 12 hours to obtain a solution C2 with a mass concentration of 6%;

[0093] Dissolve dodecanoic acid and octadecanoic acid in a mixed solution of ethanol and dichloromethane with a volume ratio of 8:2 at a m...

Embodiment 3

[0103] Prepare the solution:

[0104] Take metronidazole and add it to N,N-dimethylformamide, fully stir and ultrasonically dissolve it to obtain its saturated solution A;

[0105] Take chlorhexidine acetate and add it to trifluoroethanol, fully stir and ultrasonically dissolve it to obtain its saturated solution B;

[0106] Dissolve polycaprolactone in dichloromethane, and magnetically stir at room temperature for 12 hours to obtain a solution C1 with a mass concentration of 6%;

[0107] Dissolve polylactic acid in trifluoroethanol, and magnetically stir at room temperature for 12 hours to obtain a solution C2 with a mass concentration of 6%;

[0108] Dodecanoic acid and octadecanoic acid were dissolved in a mixed solution of ethanol and dichloromethane with a volume ratio of 2:8 at a mass ratio of 8:2, and ultrasonicated for 10 minutes to obtain a solution F with a mass concentration of 20%;

[0109] Take recombinant human platelet-derived growth factor BB and add it into ...

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Abstract

The invention relates to a fiber wound repair stent loaded with phase change material particles as well as a preparation method and application of the fiber wound repair stent. According to the invention, aliphatic polyester, a natural polymer and a phase change material are used as main raw materials, antibacterial drugs, active substance particles and growth factors are added, and the multi-layer scaffold with biological activity is prepared through electrostatic spinning, electrostatic spraying and the like. Different types of antibacterial drugs are added into the fiber wound repair stent provided by the invention, so that multiple antibacterial effects are achieved; the bioactive substance particles with the deposition density gradient increased are contained, so that cell recruitment and migration are promoted; the phase-change material particles containing the repair-promoting growth factors are used for regulating and controlling behaviors of different cells through photo-thermal trigger type controllable delivery of the growth factors. The stent material provided by the invention has excellent biocompatibility and degradation performance, can mediate migration, proliferation, differentiation and paracrine effects of cells, and can accelerate the wound repair speed and improve the wound healing effect.

Description

technical field [0001] The invention belongs to the field of biological materials, and in particular relates to a fibrous wound repair scaffold material loaded with phase change material particles, a preparation method and application thereof. Background technique [0002] Due to the increasing incidence of full-thickness skin trauma caused by mechanical injuries and burns or diabetes and malignant tumors, the repair of skin wounds has become a major medical problem in the field of wound repair. The "gold standard" of clinical treatment is autologous skin grafting; however, the lack of skin donor sites, secondary injury and risk of infection limit its application. Therefore, there is an urgent need to develop artificial wound repair scaffold materials to solve problems such as the shortage of autografts. [0003] Scaffold materials currently available clinically mainly play an isolation or antibacterial role, but their bioactivity is low and there is little loading of activ...

Claims

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Application Information

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IPC IPC(8): A61L15/26A61L15/28A61L15/32A61L15/44A61L15/46A61L15/62D01D5/00
CPCA61L15/26A61L15/32A61L15/325A61L15/28A61L15/46A61L15/44A61L15/62D01D5/003A61L2300/406A61L2300/404A61L2300/414
Inventor 薛佳佳张馨丹张立群
Owner BEIJING UNIV OF CHEM TECH
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