Personalized 3D printing meniscus regeneration stent and preparation method thereof

Abstract

The invention provides a preparation method of a personalized 3D printing meniscus regeneration stent. The preparation method comprises the following steps: S1, a stent model is prepared, and a support structure model for support the stent model is set; s2, working parameters of a high-temperature printing head, a low-temperature printing head and internal structure printing design are set on a biological 3D printer; and S3, the extruded material in the high-temperature printing head and the extruded material in the low-temperature printing head are subjected to mixed printing, and the meniscus regeneration stent is constructed in a partition printing mode that the 2 / 3 area of the inner side of the meniscus regeneration stent is set as a white area, and the 1 / 3 area of the outer side of the meniscus regeneration stent is set as a red area. The personalized 3D printing meniscus regeneration stent has the advantages that the bottom of the personalized 3D printing meniscus regeneration stent can be matched with the tibial plateau; and the regeneration and repair functions after implantation can be effectively enhanced.

Description

technical field [0001] The invention relates to the technical field of medical prosthesis, in particular to a personalized 3D printed meniscus regeneration bracket and a preparation method thereof. Background technique [0002] The meniscus is a semilunar-shaped fibrocartilage tissue located between the femoral condyle and the tibial plateau cartilage. In the knee joint, it performs functions such as cushioning and decompression, absorbing shock, lubricating the joint, and maintaining joint stability. The blood supply of the joint capsule and synovium is called the "red zone". The inner 2 / 3 area lacks blood supply and only provides nutrition through the penetration of joint fluid, which is called the "white zone". [0003] As the number of people currently participating in sports continues to increase, the incidence of meniscus injuries is also increasing accordingly. Meniscal injury can significantly affect its function. Mild cases manifest as asymptomatic or mild joint pa...

AI Technical Summary

Problems solved by technology

However, most of the brackets produced in the previous research did not restore the shape of the original meniscus 1:1, and there were still some differences in shape with the natural meniscus, so they could not match the tibial plateau at the bottom and the femoral condyle above it, resulting in easy meniscus brackets. Dislocation, or uneven distribution of stress, ultimately affecting meniscal regeneration

Moreover, different growth factors can promote cells to produce different phenotypes and secrete different components. However, in previous studies, seed cells and growth factors were mostly evenly distributed throughout the scaffold, which eventually led to the regeneration of meniscus tissue in collagen composition, cell The phenotype is relatively single, which is quite different from the heterogeneous distribution of the natural meniscus, and cannot meet the functions of the natural meniscus

Ultimately, the regenerated tissue-engineered meniscus still has a large difference in collagen composition or distribution from the natural meniscus, or the regenerated meniscal tissue has poor cartilage protection

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