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Continuous production method for recovering phenylacetic acid from 7-amino-3-vinyl cephalosporanic acid production wastewater

A technology based on cephalosporanic acid and wastewater production, applied in the field of medicine, can solve the problems of low adsorption efficiency of macroporous resins, long desorption process time, cumbersome treatment process, etc. high efficiency effect

Pending Publication Date: 2021-12-31
山东普洛得邦医药有限公司 +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The above-mentioned method 1 has a relatively cumbersome treatment process, and oxidation is a high-risk process, which is suitable for the treatment of waste liquid with high content of phenylacetic acid and many impurities; method 2 has a low adsorption efficiency of macroporous resin, and the desorption process takes a long time
[0005] The content of phenylacetic acid in the production wastewater of 7-amino-3-vinyl cephalosporanic acid is low (<1%), the impurities in the wastewater are less and the amount of wastewater is relatively large, so it is not suitable for the existing process and needs technical improvement

Method used

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  • Continuous production method for recovering phenylacetic acid from 7-amino-3-vinyl cephalosporanic acid production wastewater

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] In this example, the number of stages of the extraction tower T101 is 7, the number of revolutions is 80r / min, the waste water is acidified to a pH value of 2, the content of phenylacetic acid is 1%, the temperature of the extraction tower is 35°C, the extraction agent is butyl acetate, and the extraction agent The mass ratio to waste water is 0.05:1, the temperature of the extractant entering the tower is 35°C, and the extraction residue is extracted from the bottom of the tower. After analysis by high-efficiency gas chromatography, the content of phenylacetic acid in the extraction residue is 0.04%, and the extraction efficiency is 96.0%. The number of stages of the extraction tower T102 is 7, the number of revolutions is 80r / min, the content of the organic solvent phenylacetic acid is 19.20%, and the temperature of the extraction tower T102 is 35° C. The ratio is 6:1, the liquid caustic soda enters the tower at a temperature of 35°C, and the remaining extraction phase...

Embodiment 2

[0052] In this example, the number of stages of the extraction tower T101 is 7, the number of revolutions is 60r / min, the waste water is acidified to a pH value of 4, the content of phenylacetic acid is 0.8%, the temperature of the extraction tower is 35°C, the extraction agent is butyl acetate, and the extraction agent The mass ratio to waste water is 0.1:1, the temperature of the extractant entering the tower is 30°C, and the extraction residue is extracted from the bottom of the tower. After analysis by high-efficiency gas chromatography, the content of phenylacetic acid in the extraction residue is 0.06%, and the extraction efficiency is 92.5%. The number of stages of the extraction tower T102 is 7, the number of revolutions is 80r / min, the content of organic solvent phenylacetic acid is 7.4%, the temperature of entering the extraction tower T102 is 35°C, the organic solvent containing phenylacetic acid and liquid caustic soda (liquid caustic soda is 5% sodium bicarbonate aq...

Embodiment 3

[0055] In this example, the number of stages of the extraction tower T101 is 7, the number of revolutions is 80r / min, the waste water is acidified to a pH value of 2, the content of phenylacetic acid is 1%, the temperature of the extraction tower is 35°C, the extraction agent is butyl acetate, and the extraction agent The mass ratio to waste water is 0.05:1, the temperature of the extractant entering the tower is 35°C, and the extraction residue is extracted from the bottom of the tower. After analysis by high-efficiency gas chromatography, the content of phenylacetic acid in the extraction residue is 0.04%, and the extraction efficiency is 96.0%. The number of stages of the extraction tower T102 is 7, the number of revolutions is 60r / min, the organic solvent phenylacetic acid content is 19.2%, enters the extraction tower T102 temperature 35 ℃, contains the organic solvent of phenylacetic acid and the mass of liquid caustic soda (liquid caustic soda is 10% sodium carbonate aqueo...

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Abstract

The invention discloses a continuous production method for recovering phenylacetic acid from 7-amino-3-vinyl cephalosporanic acid production wastewater. The method comprises the following steps: acidifying wastewater, extracting phenylacetic acid in the wastewater into an organic phase by using an organic solvent, stripping the organic solvent from the extracted wastewater, directly discharging the wastewater into a sewage station, washing the organic phase containing phenylacetic acid by using liquid caustic soda, and washing phenylacetic acid in the organic phase into water; and after the washing,recycling and reusing organic phase in the raw wastewater for phenylacetic acid extraction, after washing, acidifying water phase, and then performing cooling crystallization to recover phenylacetic acid. According to the process, the problem that phenylacetic acid is difficult to recover from the phenylacetic acid-containing wastewater can be solved, the recovered phenylacetic acid can be sold as a byproduct, and after the phenylacetic acid is recovered, the wastewater can be directly discharged to a sewage station after the organic solvent is stripped, so that the environment is protected, and certain economic benefits are generated.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a continuous production method for recovering phenylacetic acid from 7-amino-3-vinyl cephalosporanic acid production wastewater. Background technique [0002] Phenylacetic acid, referred to as PAA, has a relative molecular weight of 136.15 and is a white flaky crystal with a special smell. Melting point 76.5°C, relative density 1.09, boiling point 265.5°C, slightly soluble in water, easily soluble in ethanol, ether, dichloromethane, butyl acetate and ammonia water, etc. Phenylacetic acid is chemically active, and reactions such as salt formation, esterification, and amidation can occur on the carboxyl group, and nitration, halogenation, sulfonation, oxidation, and reduction reactions can occur on the methylene or benzene ring. Phenylacetic acid is an important intermediate in organic synthesis of medicines, pesticides, and spices. Phenylacetic acid is chlorinated a...

Claims

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Application Information

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IPC IPC(8): C07C51/42C07C51/48C07C51/41C07C57/32C02F9/04C02F101/34C02F103/34C02F103/36
CPCC07C51/42C07C51/412C07C51/48C02F9/00C02F1/001C02F1/66C02F2001/5218C02F1/26C02F2101/34C02F2103/343C07C57/32
Inventor 王文江海波宋元齐李宁
Owner 山东普洛得邦医药有限公司
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