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A method for determining 35 chemical components illegally added to children's cough and asthma patches

A technology for relieving cough and asthma, and illegal addition, which is applied in measurement devices, scientific instruments, material separation, etc., and can solve the problems of single type of compound, few types of detection at one time, and complex processing of viscous rubber matrix.

Active Publication Date: 2022-02-08
潍坊市检验检测中心
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Problems solved by technology

[0003] At present, the national standards and some literatures have stipulated or discussed the illegal addition of chemical ingredients in Chinese patent medicines for cough and asthma and health food, but the types of compounds involved are single or there are few types of tests at one time, which cannot meet the needs of rapid and comprehensive testing; Moreover, due to the complicated pretreatment of the viscous rubber matrix in the patch, the drug is not easy to be extracted, and it is difficult to detect the added drug. There are few domestic and foreign literatures on the detection method of illegally added chemicals in the plaster medical device.

Method used

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  • A method for determining 35 chemical components illegally added to children's cough and asthma patches
  • A method for determining 35 chemical components illegally added to children's cough and asthma patches
  • A method for determining 35 chemical components illegally added to children's cough and asthma patches

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Embodiment 1

[0052] 1. Instruments and materials

[0053]LC-MS liquid mass spectrometry instrument: Shimadzu LC-20AD liquid phase, API4000+ mass spectrometer of AB Company of the United States; XSE-205DU electronic balance: sense weight 0.0001g, Swiss Mettler-Toledo company; 6875A type cryogenic grinder , American SPEX SamplePREP Company; ST16R centrifuge, American Thermo Fisher Corporation. Reference substances codeine phosphate (batch number: 171203-201005, content: 99.6%), dextromethorphan hydrobromide (batch number: 100201-201204, content: 94.8%), dioxpromazine hydrochloride (batch number: 100299-201803, Batch number: 99.8%), benproperine phosphate (batch number: 100237-201804, content: 99.8%), narcotine (batch number: 171224-201605, content: 100.0%), ambroxol hydrochloride (batch number: 100599-201905 , content: 99.9%), bromhexine hydrochloride (batch number: 100427-201903, content: 99.8%), albuterol (batch number: 100204-201103, content: 99.7%), ephedrine (batch number: 171241-20180...

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Abstract

The invention provides a method for determining 35 kinds of chemical components illegally added to children's anti-cough and anti-asthma patch, which comprises the following steps: freezing and grinding to prepare the test solution; Illegal addition of chemical ingredients in The method is fast, simple, and highly sensitive, and is suitable for qualitative screening and quantitative detection of 35 chemical components illegally added to children's cough and asthma patches of medical devices.

Description

technical field [0001] The invention relates to the technical field of drug detection, in particular to a method for determining 35 chemical components illegally added to children's cough-relieving and asthma-relieving patches. Background technique [0002] At present, the children's cough and asthma patch products on the Chinese market mainly include three categories: medicines, medical devices and non-drugs. Due to the advantages of convenient use, few side effects, and good compliance in children, the patch has become the first choice of many consumers for relieving cough and asthma. [0003] At present, the national standards and some literatures have stipulated or discussed the illegal addition of chemical ingredients in Chinese patent medicines for cough and asthma and health food, but the types of compounds involved are single or there are few types of tests at one time, which cannot meet the needs of rapid and comprehensive testing; Moreover, due to the complex pret...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/88
CPCG01N30/88G01N2030/884
Inventor 陈燕齐衍超李磊郎益鹏赵海鹏祁立新
Owner 潍坊市检验检测中心
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