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Novel application of Xianglian pill product

A new application technology of Xianglian pills, which is applied in the field of new applications of Xianglian pills, can solve the problems of undeveloped therapeutic effect, thick extract, and impact on capsule volume, so as to prevent atherosclerosis and ensure safety high effect

Inactive Publication Date: 2021-12-03
重庆伊士腾生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the process of Xianglian Capsules is complicated, the volatile oil is extracted first, and then the water-soluble extract is extracted; and the extract is thick, and starch is forced to be added during the capsule filling process; adding starch also affects the volume of the capsule
[0005] Xianglian Pill is a classic famous prescription, its therapeutic effect has been limited to "dysentery caused by damp heat in the large intestine, symptoms include fecal pus and blood, tenesmus, fever and abdominal pain, enteritis, bacillary dysentery, see the above symptoms", the new treatment not yet developed

Method used

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  • Novel application of Xianglian pill product
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  • Novel application of Xianglian pill product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Weigh 80g Coptis chinensis tablets and 20g Evodia rutaecarpa, reflux extract with 5 times the amount of 30% ethanol for 3 times, combine the extracts, filter and recover the solvent, concentrate into a thick paste, dry, pulverize, pack into capsules to obtain Xinxianglian capsules. HPLC (High Performance Liquid Chromatography, High Performance Liquid Chromatography) content analysis showed that Xinxianglian Capsules contained 22.5% berberine, 6.2% palmatine, 6.5% coptisine and 3.2% epiberberine. The volume of this product is smaller than that of Concentrated Xianglian Pills and Original Xianglian Capsules, it is easier to granulate, and it is more convenient to take orally; it also has the effect of resisting Helicobacter pylori (Hp) and preventing digestive tract tumors such as gastric cancer and colon cancer. It can lower blood sugar and prevent diabetic complications, lower blood fat, prevent atherosclerosis, prevent fatty liver, and lose weight.

Embodiment 2

[0028] Weigh 80g of Coptis chinensis tablets and 20g of Evodia rutaecarpa, reflux extract once with 5 times the amount of 80% ethanol, combine the extracts, filter and recover the solvent, concentrate into a thick paste, dry, crush, and pack into capsules to obtain Xinxianglian capsules. HPLC content analysis showed that Xinxianglian capsules contained 22.3% berberine, 6.1% palmatine, 6.5% coptisine and 3.1% epiberberine. The volume of this product is smaller than that of Concentrated Xianglian Pills and Original Xianglian Capsules, it is easier to granulate, and it is more convenient to take orally; it also has the effect of resisting Helicobacter pylori (Hp) and preventing digestive tract tumors such as gastric cancer and colon cancer. It can lower blood sugar and prevent diabetic complications, lower blood fat, prevent atherosclerosis, prevent fatty liver, and lose weight.

Embodiment 3

[0030] Weigh 80g Coptis chinensis tablets and 20g Evodia rutaecarpa, extract twice with 5 times the amount of 50% ethanol under reflux, combine the extracts, filter and recover the solvent, concentrate into a thick paste, dry, pulverize, pack into capsules to obtain Xinxianglian capsules. HPLC content analysis showed that Xinxianglian capsules contained 22.4% berberine, 6.2% palmatine, 6.4% coptisine and 3.1% epiberberine. The volume of this product is smaller than that of Concentrated Xianglian Pills and Original Xianglian Capsules, it is easier to granulate, and it is more convenient to take orally; it also has the effect of resisting Helicobacter pylori (Hp) and preventing digestive tract tumors such as gastric cancer and colon cancer. It can lower blood sugar and prevent diabetic complications, lower blood fat, prevent atherosclerosis, prevent fatty liver, and lose weight.

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Abstract

The invention discloses a novel application of a Xianglian (coptidis rhizoma and radix aucklandiae) pill product in preventing or treating helicobacter pylori, gastrointestinal tumors, atrophic gastritis, cardiovascular and cerebrovascular diseases and the like. The invention solves the problems that the treatment effect of Xianglian pills is always limited to dysentery caused by damp-heat of large intestines, and the symptoms are purulent and bloody stool, tenesmus, fever and abdominal pain, enteritis and bacillary dysentery, and the new treatment effect is not developed all the time. The Xianglian pill product has the effect of resisting helicobacter pylori Hp, and the safety of the Xianglian pill product is higher than that of coptidis rhizoma and coptidis rhizoma extract; the Xianglian pill product can also be used for treating gastrointestinal tumors; and in addition, the Xianglian pill product also has the effect of preventing cardiovascular and cerebrovascular diseases including atherosclerosis.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a new application of Xianglian pills. Background technique [0002] Xianglian Wan is from "Zhenghe Materia Medica" Volume 7 cited "Li Jiang Bingbu Shoujifang", which is composed of Coptis chinensis and woody fragrance. After evolution, the "Xianglian Pills" currently recorded in the Chinese Pharmacopoeia is composed of 4 parts Yuhuanglian and 1 part Muxiang. It has the functions of clearing away heat and dampness, promoting qi and relieving pain. It is used for dysentery caused by damp heat in the large intestine. Symptoms include fecal pus and blood, tenesmus, fever and abdominal pain. [0003] Because Xianglian pill contains a large amount of coptis, its taste is very poor (bitter), and its volume is very large, which is not conducive to oral administration. Therefore, the company developed it as "Concentrated Xianglian Pills". The main proce...

Claims

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Application Information

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IPC IPC(8): A61K36/718A61K9/48A61P31/04A61P35/00A61P1/04A61P9/10
CPCA61K36/718A61K36/285A61K9/48A61P31/04A61P35/00A61P1/04A61P9/10A61K2236/333A61K2236/39A61K2300/00Y02A50/30
Inventor 李学刚叶小利
Owner 重庆伊士腾生物科技有限公司
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