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Glucose biosensor and glucose biosensing membrane thereof

A biosensor and glucose technology, applied in the field of biosensors, can solve the problems of affecting the stability and service life of the sensor, increasing the cost of the sensor of the continuous glucose monitoring system, and the performance not meeting the needs of continuous glucose monitoring.

Pending Publication Date: 2021-11-30
SUZHOU ZHONGXING MEDICAL TECH CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the very strict requirements on electrodes for the detection of hydrogen peroxide by electrochemical methods, only a few materials such as platinum and platinum alloys can be used for the production of this type of glucose biosensor, which greatly increases the sensor cost of continuous glucose monitoring systems. cost
Moreover, the electrochemical detection of hydrogen peroxide also requires a higher detection potential, thus greatly reducing the anti-interference ability of the continuous glucose monitoring system, especially the anti-interference ability to commonly used antipyretic drugs such as acetaminophen
In addition, hydrogen peroxide has a strong destructive effect on glucose oxidase, which seriously affects the stability and service life of the sensor.
Although after more than 30 years of research and exploration, its performance is far from meeting the needs of continuous glucose monitoring
For example, Medtronic's Guardian and iPro2 also need to be calibrated twice a day, and their working life is only one week

Method used

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  • Glucose biosensor and glucose biosensing membrane thereof
  • Glucose biosensor and glucose biosensing membrane thereof
  • Glucose biosensor and glucose biosensing membrane thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0032] Glucose biosensing membrane, which is prepared by the following method:

[0033] Step 1), the complex compound of 1~5 parts by weight of copper, cobalt, iron, nickel, ruthenium, iridium, osmium, such as hexaamine ruthenium, ruthenium (aminobipyridine) 2 , Osmium (methoxybipyridine) 2 Osmium (methylbipyridine) 2 Osmium (bipyridine) 2 , Osmium (aminobipyridine) 2 Osmium (methylbiimidazole) 2 etc., add 2 to 10 parts by weight of a copolymer of aromatic vinyl compounds and acryloyl compounds to 500 to 2000 parts by weight of a 50% ethanol solution to react to obtain a redox polymer, and the reaction temperature is 30 to 75 ° C , the reaction time is 8 to 24 hours;

[0034] Step 2), using ultrafiltration bag dialysis to separate and purify the redox polymer; the cut molecular weight of the ultrafiltration bag dialysis is 500-20000; (optimum value: 1000)

[0035] Step 3) Mixing 0.1-1.5 parts by weight of the purified redox polymer, 0.05-1 part by weight of glucose dehyd...

specific Embodiment

[0037] Specific embodiment: glucose biosensing film, it is prepared by the following method:

[0038] Step 1), the complex compound of 2.5 grams of copper, cobalt, iron, nickel, ruthenium, iridium, osmium, such as hexaamine ruthenium, ruthenium (aminobipyridine) 2 , Osmium (methoxybipyridine) 2 Osmium (methylbipyridine) 2 Osmium (bipyridine) 2 , Osmium (aminobipyridine) 2 Osmium (methylbiimidazole) 2 Etc. and 5 grams of copolymers of aromatic vinyl compounds and acryloyl compounds are added to 1000 ml of 50% ethanol solution for reaction to obtain redox polymers. The reaction temperature is 30-75°C and the reaction time is 8-24 hours;

[0039] Step 2), using ultrafiltration bag dialysis to separate and purify the redox polymer; the cut molecular weight of the ultrafiltration bag dialysis is 500-20000; (optimum value: 1000)

[0040] Step 3) Mix the purified 0.5 gram redox polymer, 0.2 gram glucose dehydrogenase and 0.1 crosslinking agent to carry out chemical crosslinking ...

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Abstract

The invention discloses a glucose biosensor based on glucose dehydrogenase. The glucose biosensor has the advantages that the restriction of oxygen on glucose detection is fundamentally eliminated, the sensitivity, the accuracy, the reproducibility, the stability, the specificity and the anti-interference capability of a continuous glucose monitoring system are improved, the service life of the continuous glucose monitoring system is prolonged, and meanwhile, the manufacturing cost of the glucose biosensor is greatly reduced.

Description

technical field [0001] The invention relates to the technical field of biosensors, more specifically, it relates to a glucose biosensor and a glucose biosensing membrane. Background technique [0002] Since Clark and Lyon successfully developed the first biosensor in 1962, after nearly 60 years of development, biosensors have been widely used in many fields. For example, various glucose biosensors developed based on biosensing technology have benefited millions of diabetic patients. Among them, the continuous glucose monitoring system developed rapidly in recent years is favored by more and more diabetic patients, especially type I diabetic patients, due to its convenient use and real-time monitoring. As the core component of the continuous glucose monitoring system, the performance of the glucose biosensor directly determines the performance and service life of the continuous glucose monitoring system. The glucose biosensors used in the existing continuous glucose monitor...

Claims

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Application Information

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IPC IPC(8): G01N27/327
CPCG01N27/3272
Inventor 沈薇
Owner SUZHOU ZHONGXING MEDICAL TECH CO LTD
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