Sodium levofolinate product and preparation method thereof

Abstract

The invention discloses a sodium levofolinate product and a preparation method thereof, and relates to the technical field of medicine production. The sodium levofolinate product comprises a sodium levofolinate product raw material, and the sodium levofolinate product raw material is prepared from, by mass, 5 parts of sodium levofolinate, 20-25 parts of a lactose solution, 2 parts of talcum powder, 10-15 parts of a stabilizing agent, 10-12 parts of a fragrant stock solution, 12-14 parts of a protective agent and 5 parts of Chinese yam protein mixed powder. The sodium levofolinate and the lactose solution are mixed to prepare a basic solution of the sodium levofolinate oral liquid. According to the sodium levofolinate product and the preparation method thereof, by adding the stabilizing agent and the protective agent, the stability of the sodium levofolinate oral liquid can be effectively improved, so that the produced sodium levofolinate oral liquid can be stored more stably for a long time and is convenient to transport and store; the sodium levofolinate oral liquid is pressurized, the stability is higher, the drug effect of the sodium folinate oral liquid can be effectively guaranteed, and the quality of the sodium folinate oral liquid is further improved.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical production, in particular to a sodium levofolinate product and a preparation method thereof. Background technique [0002] Malignant tumors have become one of the most common diseases in our country. With population aging, urban population growth, and environmental degradation, the incidence and death toll of cancer will continue to increase across the country. Although cancer has a high mortality rate, it is not incurable. With the development of chemotherapy, radiotherapy and other treatment methods, the five-year survival rate of cancer patients is increasing year by year. At present, chemotherapy is one of the main means of comprehensive tumor treatment. With the continuous emergence of new chemotherapy drugs and adjuvant chemotherapy drugs, how to reasonably select and match various anti-tumor drug resources will improve the cure rate and prolong the survival of patients. Improving ...

AI Technical Summary

Problems solved by technology

[0003] In the prior art, patients are usually injected with sodium leucovorin by injection, and long-term injection will cause damage to the skin and blood vessels of the patient, which is not conducive to the normal recovery of the patient. In the clinical application of the product, it often occurs that patients cannot take it normally, and in the process of transportation and storage, the existing sodium levofolinate solution cannot be stored stably. In view of this, we propose a levofolinic acid solution Sodium products and methods for their preparation