A kind of preparation method of marine plant polysaccharide anti-adhesion material

A marine plant and anti-adhesion technology, which is applied in drug delivery, pharmaceutical formulation, surgery, etc., can solve the problems that sodium hyaluronate is easy to cause fever, polylactic acid degrades for a long time, and there are foreign objects in the surgical site, etc., so as to prevent adhesion and facilitate The effect of simple operation and preparation process

Active Publication Date: 2022-08-02
QINGDAO CHENLAND MARINE BIOTECH CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the anti-adhesion products on the market mainly include sodium hyaluronate, chitosan anti-adhesion film, polylactic acid, etc. Sodium hyaluronate is easy to cause fever symptoms, and the degradation time in the body is too short to effectively prevent tissue adhesion; After using chitosan for anti-adhesion, patients will feel discomfort and feel foreign objects in the surgical site, and chitosan is an animal-derived material, which has the risk of immunogenicity and virus transmission; polylactic acid degrades for a long time and exists in the The human body is prone to inflammation, and lactic acid, one of the degradation products, will stimulate the body; in addition, the above products need to be used after complete hemostasis

Method used

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  • A kind of preparation method of marine plant polysaccharide anti-adhesion material
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  • A kind of preparation method of marine plant polysaccharide anti-adhesion material

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Embodiment 1

[0026] A preparation method of marine plant polysaccharide anti-adhesion material, the specific steps are as follows:

[0027] (1) Dissolve commercially available pharmaceutical excipient grade sodium alginate with a molecular weight of 10,000 in a 0.4% w / w sodium chloride aqueous solution to make a solution with a concentration of 2% w / w; add activated carbon, activated carbon and alginic acid The mass ratio of sodium is 3:1, stirring at 30°C for 4 hours, centrifuging the mixture at 9000 rpm for 30 minutes, and taking the supernatant to obtain a sodium alginate solution;

[0028] (2) Under stirring at 50°C and 500rpm, add 1%w / w calcium chloride to the sodium alginate solution obtained in step (1) through a 26G injection needle to form gel microspheres, continue stirring for 2h, and centrifuge at 9000rpm 30min, take the precipitate and wash the gel microspheres with distilled water;

[0029] (3) after the gel microspheres cleaned in step (2) are stirred and soaked in a lactic...

Embodiment 2

[0034] A preparation method of marine plant polysaccharide anti-adhesion material, the specific steps are as follows:

[0035] (1) Dissolve commercially available pharmaceutical excipient grade potassium alginate with a molecular weight of 30,000 in a 0.6% w / w sodium nitrate aqueous solution to make a solution with a concentration of 2% w / w; add activated carbon, activated carbon and potassium alginate The mass ratio was 3:1, stirred at 40°C for 3h, centrifuged the mixture at 10,000rpm for 20min, and took the supernatant to obtain potassium alginate solution;

[0036] (2) Under stirring at 50°C and 1000rpm, add 5% w / w calcium gluconate to the potassium alginate solution obtained in step (1) through a 20G injection needle to form gel microspheres, and continue stirring for 1.5h at 10,000rpm. Centrifuge for 20min, take the precipitate and wash the gel microspheres with distilled water;

[0037] (3) after the gel microspheres cleaned in step (2) are stirred and soaked in a lacti...

Embodiment 3

[0042] A preparation method of marine plant polysaccharide anti-adhesion material, the specific steps are as follows:

[0043] (1) Dissolve oxidized sodium alginate with a molecular weight of 100,000 in a 0.9% w / w sodium lactate aqueous solution to make a solution with a concentration of 2% w / w; add activated carbon, and the mass ratio of activated carbon to oxidized sodium alginate is 3 : 1. Stir at 50°C for 0.5h, centrifuge the mixture at 12000rpm for 15min, and take the supernatant to obtain an oxidized sodium alginate solution;

[0044] (2) Under stirring at 30°C and 1500rpm, add 10% w / w calcium nitrate to the oxidized sodium alginate solution obtained in step (1) through a 24G injection needle to form gel microspheres, continue stirring for 1h, and centrifuge at 12,000rpm 15min, take the precipitate and wash the gel microspheres with distilled water;

[0045] (3) after the gel microspheres cleaned in step (2) are stirred and soaked in a lactic acid solution of pH=4 for 10 ...

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Abstract

The invention discloses a preparation method of a marine plant polysaccharide anti-adhesion material, which belongs to the technical field of biomedical materials. The invention discloses a preparation method of a marine plant polysaccharide anti-adhesion material. The pharmaceutical excipient grade alginate is used as a material, and the activated carbon is adsorbed and then centrifuged. After the gel microspheres are soaked in an acidic solution and an alkaline solution, the powder is obtained by spray drying, and finally the marine plant polysaccharide anti-adhesion material is obtained by filling and sterilization. The composition of the invention is simple and safe, the preparation process is simple and feasible, the preparation time is short, the biocompatibility is good, and the gel hemostatic adhesion can be formed after liquid absorption; Play the role of overall anti-adhesion.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a preparation method of a marine plant polysaccharide anti-adhesion material. Background technique [0002] After surgery, tissue adhesions are prone to occur, which is not only a common clinical phenomenon in the surgical field, but also a process that patients must go through during the healing process. Adhesions are abnormal structures in which fibrous bands of connective tissue bind together with adjacent tissues or organs. Adhesions can range in size from a thin film to a dense vascular scar. Postoperative tissue adhesions occur in almost any part of the body treated surgically, but are especially common after surgery in the abdomen and pelvis, tendons, and spine. It has been reported that 50%-100% of abdominal and pelvic surgeries can result in different degrees of adhesions. If the adhesion phenomenon occurs in the abdominal cavity, pelvis, bone and other o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/04A61L31/02A61L31/14A61L31/16
CPCA61L31/042A61L31/024A61L31/028A61L31/14A61L31/148A61L31/146A61L31/16A61L2400/06A61L2400/04A61L2300/412A61L2300/232C08L5/04
Inventor 王宝群刘桂亭邹圣灿林莎莎
Owner QINGDAO CHENLAND MARINE BIOTECH CO LTD
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