Method for extracting and preparing geniposidic acid from semen plantaginis

A technology of geniposide and psyllium, which is applied in the field of extraction and preparation of geniposide, can solve the problems of high professional level requirements, low geniposide content, and no utilization of psyllium, and achieve Effects of improving permeability, increasing active surface area, and increasing yield

Active Publication Date: 2021-10-01
XUCHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method takes a long time to reflux and requires a high professional level of technicians
In addition, the content of geniposide extracted is low, which is time-consuming and labor-intensive, and the psyllium is not fully utilized.

Method used

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  • Method for extracting and preparing geniposidic acid from semen plantaginis

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A method for extracting and preparing geniposide from Semen Plantago, comprising the steps of:

[0039] (1) Bead milling treatment:

[0040] Put the psyllium in the bead mill for bead milling, control the speed of the bead mill to 600rpm, bead mill until the powder can pass through the 20-mesh sieve, and not pass the 40-mesh sieve, take out the psyllium after completion powder spare;

[0041] (2) Corona treatment:

[0042] Psyllium seed powder obtained in step (1) is placed in a corona discharge apparatus for corona treatment, the control voltage is 10kV, and the time of corona treatment is 1min, and it is taken out after completion for subsequent use;

[0043] (3) Electron beam assisted soaking treatment:

[0044] The Semen Plantaginis powder after corona treatment in step (2) is immersed in the methanol solution and carries out soaking treatment, the weight-to-volume ratio of Semen Plantaginis powder and methanol solution is 1kg:10L, controls the temperature in the...

Embodiment 2

[0048] A method for extracting and preparing geniposide from Semen Plantago, comprising the steps of:

[0049] (1) Bead milling treatment:

[0050] Put the psyllium in the bead mill for bead milling, control the speed of the bead mill to 800rpm, bead mill until the powder can pass through a 25-mesh sieve, and not pass through a 50-mesh sieve, take out the psyllium after completion powder spare;

[0051] (2) Corona treatment:

[0052] The psyllium powder obtained in the step (1) is placed in a corona discharge apparatus for corona treatment, the control voltage is 12kV, and the time of corona treatment is 1.5min, and it is taken out after completion for subsequent use;

[0053] (3) Electron beam assisted soaking treatment:

[0054]The Semen Plantaginis powder after corona treatment in step (2) is immersed in methanol solution and carries out soaking treatment, and the weight-to-volume ratio of Semen Plantaginis powder and methanol solution is 1kg:11L, controls the temperatur...

Embodiment 3

[0058] A method for extracting and preparing geniposide from Semen Plantago, comprising the steps of:

[0059] (1) Bead milling treatment:

[0060] Put the psyllium in the bead mill for bead milling, control the speed of the bead mill to 1000rpm, bead mill until the powder can pass through a 30-mesh sieve, and not pass through a 60-mesh sieve, take out the psyllium after completion powder spare;

[0061] (2) Corona treatment:

[0062] Psyllium seed powder obtained in step (1) is placed in a corona discharge apparatus for corona treatment, the control voltage is 14kV, and the time of corona treatment is 2min, and it is taken out after completion for subsequent use;

[0063] (3) Electron beam assisted soaking treatment:

[0064] The Semen Plantaginis powder after corona treatment in step (2) is immersed in methanol solution and carries out soaking treatment, the weight-to-volume ratio of Semen Plantago powder and methanol solution is 1kg:12L, controls the temperature in the m...

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Abstract

The invention discloses a method for extracting and preparing geniposidic acid from semen plantaginis, which belongs to the technical field of geniposidic acid extraction, and comprises the following steps: (1) bead milling treatment; (2) corona treatment; (3) electron beam assisted soaking treatment; and (4) Soxhlet reflux extraction. According to the method for extracting and preparing geniposidic acid from semen plantaginis provided by the invention, Soxhlet reflux extraction is performed on the basis of performing bead milling crushing, corona treatment and electron beam irradiation auxiliary soaking treatment on the semen plantaginis, so that the active surface area of the semen plantaginis raw material is increased, the microporous structure of the semen plantaginis raw material is improved, and the cell permeability is improved; and permeation and diffusion of the extracting agent are promoted, so that the dissolution rate of geniposidic acid is increased, and the yield of geniposidic acid is increased.

Description

technical field [0001] The invention belongs to the technical field of extraction of geniposide, and in particular relates to a method for extracting and preparing geniposide from Semen Plantago. Background technique [0002] Semen Plantago is the dry ripe seed of Plantago asiatica L. or Plantago depressaWilld., which is cold in nature and sweet in taste, and returns to the liver, kidney, lung, and small intestine meridian. The functions of expelling dampness to relieve diarrhea, improving eyesight and eliminating phlegm are used for hot stranguria with astringent pain, edema and fullness, diarrhea due to heat-dampness, red eyes, swelling and pain, and cough due to phlegm heat. Psyllium is a commonly used traditional Chinese medicine, the main chemical components are polysaccharides, phenylethanol glycosides, iridoids, flavonoids and alkaloids and other compounds. "Chinese Pharmacopoeia" (2020 edition) uses geniposide and verbascoside as the indicators for the determination...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H1/08C07H17/04
CPCC07H1/08C07H17/04
Inventor 舒朋华黄继红魏夏兰孙军涛李念慈何林烨万佳辉方艺颖
Owner XUCHANG UNIV
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