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Traditional Chinese medicine composition for treating cervical precancerous lesions caused by HPV (human papilloma virus) infection and preparation method

A composition and technology for cervical cancer, applied in the field of medicine, can solve the problems of mucosal irritation, easy to cause allergies, poor compliance of patients with medication, etc., achieve slow and stable drug release, improve bioavailability, and enhance the effects of clearing heat and drying dampness.

Inactive Publication Date: 2021-10-01
荣汝成
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] As a new type of drug dosage form, the gel is suitable for drug administration on the skin, mucous membranes, and cavities. It can not only avoid the first-pass effect of oral administration, but also reduce the toxic and side effects of the drug. It has a slow-release effect on the release of the drug. The preparation process is simple and the appearance It is beautiful, easy to apply, easy to absorb after topical administration, does not pollute clothes, and has good stability. However, genital administration has the following problems: mucous membrane irritation, allergies, and poor patient compliance.
At the same time, the stability of traditional Chinese medicine components is not strong, and the compatibility between the components and the matrix is ​​not ideal. The effect of the prepared traditional Chinese medicine gel is not as good as that of chemical preparation gel, and the preparation process is not mature enough.

Method used

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  • Traditional Chinese medicine composition for treating cervical precancerous lesions caused by HPV (human papilloma virus) infection and preparation method
  • Traditional Chinese medicine composition for treating cervical precancerous lesions caused by HPV (human papilloma virus) infection and preparation method
  • Traditional Chinese medicine composition for treating cervical precancerous lesions caused by HPV (human papilloma virus) infection and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Weigh 20 parts of Danshen, 20 parts of Sophora flavescens, 20 parts of Fangfeng, 20 parts of Verbena, 10 parts of fresh silkworm, and 10 parts of fresh centipede. Prepared by the following method: Step 1: Weigh live centipedes and undried silkworms according to parts by weight, add 4 times the concentration of 70% ethanol according to the weight to volume ratio, soak for 8 hours to kill and sterilize, take out, add 2 times of 0.9% sodium chloride solution, crushed by a crusher or homogenized by a homogenizer, frozen in liquid nitrogen for 6 hours, taken out, added 6 times of 0.9% sodium chloride solution, stirred, soaked in a water bath at 60°C for 6 hours , squeeze the medicinal liquid, microporous filtration, ultrafiltration with an ultrafiltration membrane with a pore size of 100,000Da, and concentrate the ultrafiltrate with a nanofiltration membrane with a pore size of 800Da to obtain an animal extract with a concentration of about 0.5g medicinal material / ml ①; Step ...

Embodiment 2

[0021] Weigh 30 parts of Salvia miltiorrhiza, 30 parts of Sophora flavescens, 10 parts of Fangfeng, 10 parts of Verbena, 10 parts of fresh silkworm, and 10 parts of fresh centipede. Prepared by the following method: Step 1: Weigh live centipedes and undried silkworms according to parts by weight, add 4 times the concentration of 60% ethanol according to the weight to volume ratio, soak for 7 hours to kill and sterilize, take out, add 2 times of 0.9% sodium chloride solution, crushed by a crusher or homogenized by a homogenizer, frozen in liquid nitrogen for 5 hours, taken out, added 6 times of 0.9% sodium chloride solution, stirred, soaked in a water bath at 55°C for 12 hours , press the medicinal liquid, microporous filtration, ultrafiltration with a pore size of 100,000Da ultrafiltration membrane, and the ultrafiltrate is concentrated with a pore size of 1,000Da nanofiltration membrane to obtain an animal extract with a concentration of about 0.5g medicinal material / ml ①; Ste...

Embodiment 3

[0023] Weigh 30 parts of Danshen, 10 parts of Sophora flavescens, 20 parts of Fangfeng, 10 parts of Verbena, 15 parts of fresh silkworm, and 15 parts of fresh centipede. Prepared by the following method: Step 1: Weigh live centipedes and undried silkworms according to the parts by weight, add 4 times the concentration of 80% ethanol according to the weight to volume ratio, soak for 2 hours to kill and sterilize, take out, add 2 times of 0.9% sodium chloride solution, crushed by a crusher or homogenized by a homogenizer, frozen in liquid nitrogen for 4 hours, taken out, added 6 times of 0.9% sodium chloride solution, stirred, soaked in a water bath at 60°C for 4 hours , squeeze the medicinal liquid, microporous filtration, ultrafiltration with an ultrafiltration membrane with a pore size of 100,000Da, and concentrate the ultrafiltrate with a nanofiltration membrane with a pore size of 500Da to obtain an animal extract with a concentration of about 0.5g medicinal material / ml ①; S...

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Abstract

The invention relates to a traditional Chinese medicine composition for treating cervical precancerous lesions caused by HPV (human papillomavirus) infection and a preparation method thereof, the traditional Chinese medicine composition is prepared from salvia miltiorrhiza, radix sophorae flavescentis, divaricate saposhnikovia root, verbena, fresh stiff silkworm and fresh centipede, the problem of poor stability caused by polypeptide, phenolic acid and alkaloid components is solved through separation and purification technical design, and the composition is mainly prepared by clearing damp-heat toxin and removing blood stasis to remove stasis. According to the traditional Chinese medicine gel disclosed by the invention, the negative conversion rate of HPV infection can be greatly improved, the process design is reasonable, the compatibility of the extract and the matrix is good, and the quality of the traditional Chinese medicine gel is greatly improved while the medication safety is ensured.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a traditional Chinese medicine composition and a preparation method for treating cervical precancerous lesions caused by HPV infection. Background technique [0002] Cervical cancer is the most common gynecological malignancy, with more than 500,000 new cases and more than 200,000 deaths each year. In recent years, the incidence of cervical cancer in my country is on the rise, and the incidence population tends to be younger. It is especially important for the prevention and treatment of cervical precancer. At present, the treatment methods of Western medicine for cervical cancer are mainly drugs, physical therapy (mild) and surgical resection (moderate to high). [0003] The main pathogenic factor of cervical cancer is the persistent infection of human papillomavirus (HPV). Studies have found that more than 70% of cervical cancers are related to HPV infection. HPV ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/85A61K9/06A61K47/38A61K35/64A61K35/648A61P15/00A61P35/00A61P31/20
CPCA61K36/537A61K36/489A61K36/238A61K36/85A61K35/64A61K35/648A61K9/06A61K9/0034A61K47/38A61P15/00A61P35/00A61P31/20A61K2236/331A61K2236/39A61K2236/55A61K2236/53A61K2300/00
Inventor 荣汝成
Owner 荣汝成
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