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Active-oxygen-responsive degradable polyurethane heart patch for myocardial infarction repair and preparation method thereof

A technology of myocardial infarction and polyurethane, which is applied in medical science, prosthetics, tissue regeneration, etc., can solve the problems of lack of functionality, and achieve the effect of simple preparation method, easy realization, and repair of heart function

Pending Publication Date: 2021-09-24
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The heart patch has excellent mechanical properties and good biocompatibility, and can provide mechanical support for the myocardium; more importantly, it can consume excess active oxygen in the microenvironment of myocardial infarction, restore the function of the heart after myocardial infarction, and solve the problem of Lack of functionality of existing synthetic polymer heart patch materials

Method used

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  • Active-oxygen-responsive degradable polyurethane heart patch for myocardial infarction repair and preparation method thereof
  • Active-oxygen-responsive degradable polyurethane heart patch for myocardial infarction repair and preparation method thereof
  • Active-oxygen-responsive degradable polyurethane heart patch for myocardial infarction repair and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Active oxygen responsive degradable unsaturated polyurethane material (PFTU-1:1), including a soft segment and a hard segment, the soft segments are respectively polytrimethylene fumarate (PPF) and polyketone with a number average molecular weight of 1000 Thiol (PTK), the molar ratio of the two feeds is 1:1; the hard segment is an aliphatic diisocyanate such as hexamethylene diisocyanate (HDI) and a small molecule diamine chain extender such as dimethyl lysine (Lys-OMe).

[0032]Take 1.000g of PPF and 1.000g of PTK with a number average molecular weight of 1000 and add them to two dry two-necked flasks respectively, and calculate the number of hydroxyl moles of PPF and the number of mercapto groups of PTK to be 1.000mmol and 1.000mmol respectively. Distilled under pressure for 1h to remove residual moisture, and nitrogen gas was introduced. After cooling down to 70°C, add 10 mL of anhydrous 1,4-dioxane solvent to the PPF bottle for dissolution, then add 288 μL HDI and ...

Embodiment 2

[0034] Dissolve 1.0 g of reactive oxygen-responsive degradable unsaturated polyurethane material (PFTU) in 10 mL of tetrahydrofuran, pour it into a polytetrafluoroethylene mold, and evaporate it in air at room temperature for 48 hours, then dry it in vacuum at 37°C for 48 hours to completely remove the solvent , to obtain active oxygen responsive degradable polyurethane heart patch. The heart patch tensile strength that this pouring method obtains is 7.2MPa, and tensile modulus is 17.9MPa, and elongation at break is 760%; H 2 o 2 After 28 days of degradation in solution, the mass loss was 12.41%. The active oxygen-responsive degradable polyurethane heart patch obtained by this casting method is used to restore cardiac function after myocardial infarction.

Embodiment 3

[0036] 0.75 g of active oxygen-responsive degradable polyurethane was dissolved in 5 mL of hexafluoroisopropanol solution, wherein the mass concentration of polyurethane obtained was 15%, and the nanofiber membrane was prepared by spinning with an electrospinning device. Electrospinning parameters are: spinning temperature is 25-30°C, humidity is 30-40%, spinning voltage is 15kV, liquid supply speed is 1mL / h, roller receiving distance is 10cm, receiving length is 5cm, rotating speed is 200rad / min. The prepared nanofiber membrane was dried in a vacuum oven at 25° C. for 24 hours. A random electrospun fiber membrane was obtained with a fiber diameter of 700 nm and a thickness of 0.06 mm. The polyurethane electrospun fiber membrane heart patch has good mechanical properties, the tensile strength is 10MPa, and the tensile strain is 400%. This electrospinning method was used to obtain active oxygen responsive degradable polyurethane electrospun fiber heart patch for repairing car...

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Abstract

The invention discloses an active-oxygen-responsive degradable polyurethane heart patch for myocardial infarction repair and a preparation method thereof. The heart patch comprises a cast membrane, an electrospun fibrous membrane and a porous membrane, and polyurethane is active-oxygen-responsive degradable polyurethane containing thioketal bonds. The invention also provides a method for preparing the heart patch. The preparation method is simple and is convenient to operate, active-oxygen polyurethane films with different pore sizes and porosities can be prepared as required, and the active-oxygen polyurethane films have good mechanical properties, oxidation resistance, degradability and biocompatibility. Under the condition that functional cells or factors are not added into the polyurethane patch, cardiac functions can be effectively recovered after myocardial infarction, and the left ventricle remodeling and fibrosis degree after myocardial infarction can be inhibited; and after the cells or active factors are added, the treatment effect can be further improved. The active-oxygen-responsive degradable elastic polyurethane heart patch disclosed by the invention is simple in preparation method and has a good application prospect.

Description

technical field [0001] The invention relates to a heart patch, in particular to an active oxygen responsive degradable polyurethane heart patch for repairing myocardial infarction and a preparation method thereof. Background technique [0002] Myocardial infarction is still one of the main causes of human morbidity and death in the world, causing nearly 7.3 million deaths every year. Unlike other diseases, the heart lacks the ability to regenerate, and damaged heart muscle cannot repair itself. After myocardial infarction, a large number of myocardial cell death will activate the inflammatory response, and collagen deposition occurs in myocardial tissue, resulting in myocardial fibrosis in the infarcted area. Pathological factors in ischemic myocardium and marginal zone tissue, including excess reactive oxygen species (ROS), local inflammatory storm, and elevated ventricular wall stress, collectively lead to adverse remodeling of the left ventricle after myocardial infarcti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/50A61L27/54A61L27/38
CPCA61L27/18A61L27/50A61L27/54A61L27/3834A61L27/3804A61L27/3813A61L2430/20A61L2300/412C08L75/14
Inventor 高长有姚跃君解洁奇
Owner ZHEJIANG UNIV
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