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Externally applied medicine for improving blood supply of skin flaps and preparation method of externally applied medicine

A technology for external medicine and blood circulation, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc. It can solve the problems of increasing the risk of complications related to dilated skin, substandard blood quality of patients, The preparation process is time-consuming and labor-intensive, and achieves the effects of preventing and treating complications related to the expanded skin, improving the bad state of the skin, and preventing and treating the complications related to the expanded skin

Pending Publication Date: 2021-09-17
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Botulinum toxin type A injection: intramuscular injection is required, which is more painful and poorly accepted by patients; it will cause trauma to the expanded area and increase the risk of complications related to the expanded skin; and the treatment effect is uncertain
[0005] Coating with gelatin sponge: For certain parts such as the head and face, or larger dilators, it is difficult to cover with gelatin sponge, and there are limitations in its use
[0006] CGF injection: Blood collection is required, and the blood quality of some patients is not up to standard; it will cause damage to the expanded area and increase the risk of complications related to the expanded skin
[0007] Stem cell injection: Stem cells need to be obtained through invasive operations or surgery, and the preparation process is time-consuming and laborious; the ethical aspects are not yet clear; trauma to the expanded area increases the risk of complications related to the expanded skin
[0008] Autologous fat transplantation: fat needs to be obtained through liposuction, and many patients have less subcutaneous fat, which cannot meet the needs of transplantation
[0009] Apply drugs on the surface of the expanded skin, such as triamcinolone, sucralfate, papaverine, etc.: the side effects of the drug itself, the clinical application is limited

Method used

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  • Externally applied medicine for improving blood supply of skin flaps and preparation method of externally applied medicine
  • Externally applied medicine for improving blood supply of skin flaps and preparation method of externally applied medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] An external medicine for improving the blood supply of skin flaps and a preparation method thereof,

[0040] ① Accurately weigh the following raw materials:

[0041] Basic fibroblast growth factor freeze-dried powder 500,000 IU (about 5g), minoxidil freeze-dried powder 5g, urea 20g, dimethyl sulfoxide 5mL, lauryl nitrogen, ketone 3ml, stearic acid 4.5g, division 1.25g of pan 60, 4.5g of stearyl alcohol, 7g of liquid paraffin, 4.5g of white vanilla, 3.5g of polysorbate 80, 8g of glycerin, 0.2g of sorbic acid, and an appropriate amount of purified water, making a total of 100g.

[0042] ② Minoxidil freeze-dried powder was dissolved in dimethyl sulfoxide for later use, and basic fibroblast growth factor freeze-dried powder was dissolved in purified water for later use.

[0043] ③Take the oil phase components stearic acid, Span 60, stearyl alcohol, liquid paraffin, white vanilla, lauryl nitrogen, and ketone, heat and melt on a water bath, and control the temperature at 75°...

Embodiment 2

[0050] Substantially the same as Example 1, the difference is: accurately weigh the following various raw materials:

[0051]Basic fibroblast growth factor freeze-dried powder 100,000 IU (about 1g), minoxidil freeze-dried powder 2g, urea 27g, dimethyl sulfoxide 5mL, lauryl nitrogen, ketone 3ml, stearic acid 4.5g, division 1.25g of pan 60, 4.5g of stearyl alcohol, 7g of liquid paraffin, 4.5g of white vanilla, 3.5g of polysorbate 80, 8g of glycerin, 0.2g of sorbic acid, and an appropriate amount of purified water, making a total of 100g.

Embodiment 3

[0053] Substantially the same as Example 1, the difference is: accurately weigh the following various raw materials:

[0054] Basic fibroblast growth factor freeze-dried powder 200,000 IU (about 2g), minoxidil freeze-dried powder 4g, urea 24g, dimethyl sulfoxide 5mL, lauryl nitrogen, ketone 3ml, stearic acid 4.5g, division 1.25g of pan 60, 4.5g of stearyl alcohol, 7g of liquid paraffin, 4.5g of white vanilla, 3.5g of polysorbate 80, 8g of glycerin, 0.2g of sorbic acid, and an appropriate amount of purified water, making a total of 100g.

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Abstract

The invention relates to an externally applied medicine for improving blood supply of skin flaps and a preparation method of the externally applied medicine. The externally applied medicine is prepared from 1000-5000 IU / mL of basic fibroblast growth factors, 10-50 mg / mL of minoxidil and 100-300 mg / mL of urea. The external applied medicine is safe, convenient, efficient and rapid and is used for preventing and treating skin expansion related complications and improving blood supply of expanded skin flaps. When a patient has poor dilation early warning signs such as capillary hyperplasia, skin thinning, transparency and the like in dilated skin tissue, the external applied medicine is applied to the surface of the dilated skin locally, so that the bad state of the skin during dilation can be improved, the regeneration of the dilated skin can be promoted, and the related complications of the dilated skin can be effectively prevented and treated.

Description

technical field [0001] The invention relates to the field of surgery-plastic repair and reconstruction of skin and soft tissue tissues, in particular, it refers to the development of new drugs applied to the treatment of skin and soft tissue expanders to improve the expansion efficiency and reduce expansion-related complications. Background technique [0002] Skin tissue defect is a common problem in plastic and reconstructive surgery. Soft tissue expansion technology is an ideal repair method because it can provide skin tissue with similar skin color and texture. However, the complication rate of soft tissue expansion can reach 17.44%, which is directly related to the limited regenerative ability of skin tissue. In clinical practice, capillary hyperplasia, skin thinning, and translucence in dilated skin tissue are early warning signs of poor dilatation, and the progression of these signs can lead to serious complications such as skin ulcers and even necrosis. When relevant...

Claims

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Application Information

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IPC IPC(8): A61K38/18A61K9/06A61K47/10A61K47/12A61K47/20A61K47/26A61P17/00A61K31/17A61K31/506
CPCA61K38/1825A61K31/506A61K31/17A61K9/0014A61K9/06A61K47/26A61K47/10A61K47/12A61K47/20A61P17/00A61K2300/00Y02A50/30
Inventor 谢芸方斌李青峰
Owner SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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