Anti-acne and anti-inflammatory composition and preparation method and application thereof

An anti-inflammatory composition and a technology of the composition, applied in the field of daily chemicals, can solve the problems of unsafe and improper, skin barrier damage, blackheads and enlarged pores, etc.

Active Publication Date: 2021-08-20
COSMAX CHINA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, the use of some unsafe and improper anti-acne products may contain ingredients such as keratin exfoliants and glucocorticoids. Long-term use can damage the integrity of the stratum corneum, inhibit the lipid synthesis of the stratum corneum, and cause damage to the skin barrier
[0006] At present, the main solution of acne products on the market is to inhibit the excessive reproduction of Propionibacterium acnes and the inflammatory immune response, while ignoring the improvement of sebum quality and prevention of abnormal keratinization, and the improvement of problems such as blackheads and enlarged pores is small

Method used

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  • Anti-acne and anti-inflammatory composition and preparation method and application thereof
  • Anti-acne and anti-inflammatory composition and preparation method and application thereof
  • Anti-acne and anti-inflammatory composition and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0029] In the following examples and comparative examples of the present invention, the antipruritic and soothing composition is prepared by the following process.

[0030] (1) Pulverize the plant raw materials respectively, dry them, pass through a 60-mesh sieve, weigh them according to the proportioning ratio, and mix them evenly;

[0031] (2) adding ethanol for extraction, the mass ratio of the crude drug to ethanol (35%) is 1:20, the extraction temperature is 50°C, the microwave is 7min, the ultrasonic time is 40min, and the extraction times is 2 times;

[0032] (3) cooling the extract obtained in step (2) to 25° C., filtering with 200 mesh gauze to obtain the initial filtrate;

[0033] (4) centrifuging the primary filtrate obtained in step (3) for 30min, the rotating speed is 6000rpm with a microfiltration membrane with a pore size of 0.5 μm to filter, collect the filtrate, and obtain the secondary filtrate;

[0034] (5) Concentrate the secondary filtrate obtained in ste...

experiment example 1

[0045] Antibacterial test

[0046] Bacteriostatic effect detection

[0047] Selection of strains: Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Propionibacterium acnes; Pseudomonas aeruginosa \ Staphylococcus aureus \ Escherichia coli \ Propionibacterium acnes were selected for the preparation of bacterial solution for the listed species. Preparation: Dilute it with sterile physiological saline to a bacterial suspension of about 1.0x105cfu / ml~1.0x106cfu / ml. The prepared bacterial suspension should be used within 2 hours, or stored at 2°C to 8°C for no more than 24h.

[0048]Bacteriostatic effect test: Take the functional plant composition obtained in step (5) of the example, take a piece of sterile dry filter paper, and add 20 μL of the plant composition solution (10 mg / mL) of the actual concentration to each piece dropwise. Test bacteria inoculation: Take 1mL of each test bacteria suspension and spread evenly on the surface of the nutrient agar medium; p...

experiment example 2

[0055] Experimental example 2. In vitro antioxidant test

[0056] 1. DPPH free radical scavenging test

[0057] Precisely pipette 2.0mL of 50% ethanol DPPH solution (0.2mmol / L), add 2.0mL of the test solution, mix well and shake well, after 30min, measure the absorbance A at 517nm, measure 3 times in parallel, and take the average value , with vitamin C as a positive control. Calculate the scavenging rate of each test solution to DPPH free radicals by the following formula:

[0058] DPPH clearance rate (%) = [1-(A i -A j ) / A 0 ]*100%

[0059] In the formula: Ai is the absorbance of the reaction after adding the test substance;

[0060] Aj is the absorbance of the test solution itself;

[0061] A0 is the blank value without adding test solution.

[0062] 2. OH ​​radical scavenging test

[0063] Hydroxyl radicals were generated using the Fenton reaction. Add 1.0mL of FeSO4 solution (9.0mmol / L), 1.0mL of salicylic acid ethanol solution (9.0mmol / L) and 1.0mL of test solu...

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Abstract

The invention discloses an anti-acne and anti-inflammatory composition and a preparation method and application thereof. The anti-acne and anti-inflammatory composition comprises a herba trifolii pratentis extract, bakuchiol, a radix scutellariae extract and a solvent acceptable in the field of cosmetics. The red clover extract and the radix scutellariae extract are an ethanol extract a herba trifolii pratentis raw medicine and an ethanol extract of a radix scutellariae raw medicine respectively; wherein the mass ratio of the herba trifolii pratentis raw medicine to the bakuchiol to the radix scutellariae raw medicine is (1-5): (0.01-0.1): (1-5); and the solvent acceptable in the field of cosmetics includes polyol. The composition improves sebum quality while effectively inhibiting acnes, shrink pores and can effectively improve the sebum quality.

Description

technical field [0001] The invention belongs to the field of daily chemicals, and relates to an anti-acne and anti-inflammatory composition, a preparation method and application thereof. Background technique [0002] Acne is a common skin problem in the population. It is a series of inflammatory reactions caused by the inability of the skin to excrete oil normally. It is a chronic inflammatory skin symptom that occurs in the pilosebaceous gland tissue. Strong secretion area. [0003] The causes of acne are relatively complex, usually the result of a combination of multiple factors, the main causes are abnormal regulation of sebaceous glands by androgen, abnormal keratinization of sebaceous gland ducts, excessive proliferation of Propionibacterium acnes, and inflammatory immune responses. [0004] The main component of sebum is squalene, which is a flowing liquid at room temperature. When it is oxidized, it becomes a viscous liquid of linseed oil, which is easy to remain in ...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61K8/34A61Q19/00A61P29/00A61P17/10
CPCA61K8/9789A61K8/347A61K8/345A61Q19/00A61P29/00A61P17/10A61K2800/10A61K2800/5922
Inventor 马艺宸周秋娜金荣熙陈欢尹锺赫金延埈
Owner COSMAX CHINA INC
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