Application of P2Y12 receptor and antagonist thereof in diagnosis and treatment of acute pancreatitis

A technology for acute pancreatitis and P2Y12, applied in the field of biomedicine, can solve problems such as deficiency, and achieve good application prospects

Inactive Publication Date: 2021-08-17
THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIV
View PDF1 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Evidence on the exact role of non-platelet P2Y12 receptors is still lacking, and there are no prior art reports that P2Y12 can promote the development of acute pancreatitis

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of P2Y12 receptor and antagonist thereof in diagnosis and treatment of acute pancreatitis
  • Application of P2Y12 receptor and antagonist thereof in diagnosis and treatment of acute pancreatitis
  • Application of P2Y12 receptor and antagonist thereof in diagnosis and treatment of acute pancreatitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) Experimental animals

[0023] 20g-25g male wild-type C57BL / 6 mice and P2Y12 gene knockout mice (gene knockout mice were donated by Professor Liu Junling, School of Medicine, Shanghai Jiaotong University; wild-type mice were purchased from Beijing Weitong Lihua Company).

[0024] (2) Experimental process

[0025] The mice were randomly divided into 4 groups, namely wild-type control group (WT1), wild-type model group (WT2), gene knockout control group (KO1) and gene knockout model group (KO2), with 10 mice in each group. Each group of the model group adopts the "retrograde injection of sodium taurocholate into the pancreaticobiliary duct" method, and injects 5% sodium taurocholate (dose: 10 μL / mouse) into the retrograde pancreaticobiliary duct through the intestinal wall to establish severe acute pancreatitis in mice. (SAP) model. The control group was injected with the same amount of 0.9% normal saline by the same method.

[0026] Gene identification of mice: cut...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses an application of a P2Y12 receptor and an antagonist thereof in diagnosis and treatment of acute pancreatitis, and discloses an application of the P2Y12 receptor as a target in screening of a diagnostic reagent for acute pancreatitis and an application of the P2Y12 receptor as a biomarker in screening of the diagnostic reagent for acute pancreatitis, provides a new target spot and a biomarker screened by a diagnostic reagent for the diagnosis of acute pancreatitis; meanwhile, the invention discloses application of the P2Y12 antagonist in preparation of drugs for treating acute pancreatitis, and provides a new treatment basis and a drug screening basis for treatment of acute pancreatitis. Therefore, the P2Y12 receptor and the antagonist thereof have a good application prospect and an important research value.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and specifically relates to the application of a P2Y12 receptor and its antagonist in the diagnosis and treatment of acute pancreatitis. Background technique [0002] The P2Y12 receptor plays a key role in platelet activation and is the main target of antithrombotic drugs. However, the beneficial effects of P2Y12 receptor antagonists may not be limited to primary and secondary prevention of arterial thrombosis. In recent years, studies have shown that the activation of platelet P2Y12 receptors causes platelet activation, through the promotion of cytokine release, the interaction between platelets and leukocytes, and the formation of neutrophil extracellular trapping network. play an important role. In addition, nonplatelet P2Y12 receptors on the surface of immune cells and vascular smooth muscle cells may also be effective players in the inflammatory response. The key role of P2Y12 recepto...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/74G01N33/68C12Q1/6883A61K45/00A61P1/18
CPCG01N33/74C12Q1/6883A61K45/00A61P1/18G01N2333/726G01N2800/067
Inventor 许春芳周小冲翁震
Owner THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap