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Composite hemostatic repair material and preparation method thereof

A technology for repairing materials and composite materials, which is applied in the field of composite hemostatic repairing materials and its preparation, which can solve problems such as limited hemostatic effect, difficulty in popularization, and complicated preparation process, and achieves simple and easy-to-operate preparation methods, good hemostatic effect, and promotion of metabolism Effect

Active Publication Date: 2021-08-13
HEBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] CN102605459A discloses a tourmaline / chitosan composite material and a preparation method thereof. Using tourmaline and chitosan as raw materials, tourmaline particles are dispersed in the chitosan fiber matrix by stirring dispersion and electrospinning. Very limited hemostatic effect
Sun Rongzhan used shells and chitosan as raw materials to prepare shell powder / chitosan composite hemostatic repair materials through supercritical flow foam technology. Hemostatic experiments using animal models in vivo obtained good hemostatic effects. The preparation process is relatively complicated and the conditions required are harsh, so it is difficult to be popularized

Method used

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  • Composite hemostatic repair material and preparation method thereof
  • Composite hemostatic repair material and preparation method thereof
  • Composite hemostatic repair material and preparation method thereof

Examples

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Embodiment 1

[0037] (1) Wash the natural clam shells with deionized water and crush them, put the shell fragments in a pulverizer for 5 minutes, pass the obtained shell powder through a 200-mesh sieve, and then calcinate the shell powder in a muffle furnace at 300 °C 2h, that is, the required shell powder raw material is obtained;

[0038] (2) Take 1.584g of ammonium hydrogen phosphate and dissolve it in 50ml of deionized water, add 2.000g of shell powder under stirring conditions, then add tourmaline powder in the ratio of shell:tourmaline=8:1, adjust pH=9 with ammonia water, room temperature Stir for 1 hour under the same conditions, then sonicate for 0.5 hours, and stir again for 1 hour; the particle size range of tourmaline particles used is 1-10 μm, and micron-sized tourmaline needs to be mixed with deionized water and then ultrasonically dispersed to reduce agglomeration. Add tourmaline dispersion directly during stirring;

[0039] (3) Pour the above mixture into a 100ml hydrotherma...

Embodiment 2

[0047] (1) Wash the natural clam shells with deionized water and crush them, put the shell fragments in a pulverizer for 5 minutes, pass the obtained shell powder through a 200-mesh sieve, and then calcinate the shell powder in a muffle furnace at 300 °C 2h, that is, the required shell powder raw material is obtained;

[0048] (2) Take 1.584g of ammonium hydrogen phosphate and dissolve it in 50ml of deionized water, add 2.000g of shell powder under stirring conditions, then add tourmaline powder in the ratio of shell:tourmaline=2:1, adjust pH=9 with ammonia water, room temperature Stir for 1 hour under the same conditions, then sonicate for 0.5 hours, and stir again for 1 hour; the particle size range of tourmaline particles used is 1-10 μm, and micron-sized tourmaline needs to be mixed with deionized water and then ultrasonically dispersed to reduce agglomeration. Add tourmaline dispersion directly during stirring;

[0049] (3) Pour the above mixture into a 100ml hydrotherma...

Embodiment 3

[0053] (1) Wash the natural clam shells with deionized water and crush them, put the shell fragments in a pulverizer for 5 minutes, pass the obtained shell powder through a 200-mesh sieve, and then calcinate the shell powder in a muffle furnace at 300 °C 2h, that is, the required shell powder raw material is obtained;

[0054] (2) Take 1.584g of ammonium hydrogen phosphate and dissolve it in 50ml of deionized water, add 2.000g of shell powder under stirring conditions, then add tourmaline powder in the ratio of shell:tourmaline=8:1, adjust pH=9 with ammonia water, room temperature Stir for 1 hour under the same conditions, then sonicate for 0.5 hours, and stir again for 1 hour; the particle size range of tourmaline particles used is 1-10 μm, and micron-sized tourmaline needs to be mixed with deionized water and then ultrasonically dispersed to reduce agglomeration. Add tourmaline dispersion directly during stirring;

[0055] (3) Pour the above mixture into a 100ml hydrotherma...

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Abstract

The invention relates to a composite hemostatic repair material and a preparation method thereof. The hemostatic repair material is characterized in that a shell and tourmaline are adopted as main raw materials, the shell and a phosphorus source can be converted into hydroxyapatite, and chitosan sponge is used as a matrix for loading. According to the preparation method, the shell and the tourmaline are used as the main raw materials, ammonium hydrogen phosphate is used as the phosphorus source for a hydrothermal reaction, a self-generating electric field on the surface of the tourmaline has an attraction effect on charged ions in a system, the hydroxyapatite obtained through hydrothermal conversion of the shell grows on the surface of the tourmaline in situ to obtain a shell / tourmaline composite material, and then the shell / tourmaline composite material is embedded into a chitosan sponge matrix through a freeze drying process to prepare the shell / tourmaline composite hemostatic repair material. The hemostasis repair material can remarkably shorten the blood coagulation time, and achieves a good hemostasis effect.

Description

technical field [0001] The invention relates to the technical field of hemostatic repair materials, in particular to a composite hemostatic repair material and a preparation method thereof. Background technique [0002] For a long time, blood loss has been a great threat to people's life safety. According to statistics, the annual hemorrhagic shock death accounts for 30%-40% of traumatic injury deaths. In an emergency, it is very important to be able to achieve rapid hemostasis, and the hemostatic mechanism of the human body is a relatively complicated and time-consuming process. In some severe traumas, it is difficult to complete hemostasis only relying on the body's own hemostatic function At this time, it is necessary to apply external intervention to the wound to achieve the purpose of rapid hemostasis. Therefore, the development of high-efficiency hemostatic materials has become the key to rapid hemostasis and reduction of bleeding mortality. However, there are very f...

Claims

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Application Information

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IPC IPC(8): A61L24/08A61L24/02A61L24/00
CPCA61L24/0084A61L24/0089A61L24/0005A61L24/0036A61L2400/04A61L2300/102A61L2300/418C08L5/08
Inventor 孟军平郭涛梁金生
Owner HEBEI UNIV OF TECH
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