Selenium/double-layer silicon dioxide spherical shell nanoparticles and composition thereof

A nanoparticle and silicon dioxide technology, which is applied in the direction of drug combination, sulfur/selenium/tellurium active ingredients, wave energy or particle radiation treatment materials, etc., can solve the problem of small therapeutic dose and toxic dose window, limited application, and easy poisoning and other issues, to achieve the effect of long service life, improved accuracy and short production cycle

Pending Publication Date: 2021-08-13
BEIJING FRIENDSHIP HOSPITAL CAPITAL MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the small therapeutic dose and toxic dose window of Se, poisoning is prone to occur during treatment, which limits its clinical application.

Method used

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  • Selenium/double-layer silicon dioxide spherical shell nanoparticles and composition thereof
  • Selenium/double-layer silicon dioxide spherical shell nanoparticles and composition thereof
  • Selenium/double-layer silicon dioxide spherical shell nanoparticles and composition thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0130] Embodiment 1 Preparation of selenium / double-layer silica spherical shell nanoparticles

[0131](1) Dissolve 0.3g of selenium powder and 15g of sodium hydroxide in 40mL of deionized water. After the selenium powder is completely dissolved, add 2mL of N 2 h 4 ·H 2 O, 0.568g CuCl 2 2H 2 O and 2mL oleylamine, kept at 100°C for 2h, cooled rapidly, and washed with centrifuged ethanol three times, the obtained Cu 2-x Se nanocrystals, the product was dispersed in n-hexane.

[0132] (2) Mix 0.9mL deionized water, 3mL n-hexanol, 3mL Triton X-100 and 30mL n-hexane evenly, and add 1mL of the above (1) solution. After stirring for 5min, 0.18mL tetraethyl orthosilicate was added dropwise thereto, and 0.18mL ammonia water (28wt%) was added dropwise after another 5min, and reacted for 24h, and then centrifuged and washed several times with ethanol to obtain Se@SiO 2 , and then dispersed in ethanol, Se / SiO2 (Se@SiO 2 ) low magnification transmission electron microscope (TEM) pict...

Embodiment 2

[0134] Embodiment 2 selenium release assay

[0135] The Se@SiO prepared in Example 1 2 @mSiO 2 Nanomaterials were dissolved in phosphate-buffered saline (PBS) solution at pH 7.4. In the case of stirring, the supernatant was collected by centrifugation at a preset time and used for inductively coupled plasma (ICP) to determine the concentration of selenium. Continue to add the same amount of corresponding phosphate-buffered saline (PBS) solution to the centrifuged product, continue to stir, and repeat this operation step.

[0136] The Se@SiO prepared in Example 1 2 Dissolve in phosphate buffered saline (PBS) solution at pH 7.4. In the case of stirring, the supernatant was collected by centrifugation at a preset time and used for inductively coupled plasma (ICP) to determine the concentration of selenium. Continue to add the same amount of corresponding phosphate-buffered saline (PBS) solution to the centrifuged product, continue to stir, and repeat this operation step.

...

Embodiment 3

[0138] Example 3 Toxicity identification of selenium / double-layer silica spherical shell nanoparticles to vital organs of rats

[0139] The Se@SiO prepared in Example 1 2 @mSiO 2 Nanomaterials dissolved in ddH 2 In O, the concentration of 1 mg / kg was injected intraperitoneally into 6 SD rats (body weight 250–300 g; age 12 months; culture level SPF grade), and 6 rats in the control group were injected with the same amount of ddH in the same way. 2 O. The frequency of injections was once daily for 14 days. Four weeks after the drug injection, the rats were sacrificed under intraperitoneal anesthesia with 2.5% pentobarbital sodium, and the heart, liver, spleen, lung, and kidney tissues were fixed in formalin, and HE staining was performed to observe the tissue morphology. Se@SiO 2 @mSiO 2 Toxicity to heart, liver, spleen, lung, kidney and other important organs. The experimental results show that Se@SiO 2 @mSiO 2 Nanomaterials have strong tissue security. Toxicity identi...

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Abstract

The invention discloses selenium / double-layer silicon dioxide spherical shell nanoparticles. The nanoparticles comprise Se in an inner core and a double-layer SiO2 shell, wherein the diameter of the shell is 10-200nm. The nanoparticles can carry sufficient Se, can be slowly released at a stable rate within a long time range, and can be used in any mode such as injection, oral administration, smearing and application.

Description

technical field [0001] The invention belongs to the technical field of carriers, in particular to a composition containing selenium / double-layer silica spherical shell nanoparticles. Background technique [0002] In recent years, due to exogenous and endogenous factors such as living habits, environmental pollution, genetics, and immunity, the number of people suffering from cancer has increased rapidly. Carcinogens in the urinary system often cause tumors in the urothelium through urine, and urothelial tumors in the renal pelvis, ureter, bladder, and urethra all have common features and may cause multiple organ diseases. Bladder cancer is the most common because urine stays in the bladder for the longest time. [0003] Zhou Kai et al published in "The Efficacy of Transurethral Holmium Laser Bladder Tumor Resection in the Treatment of Patients with Bladder Cancer and Its Influence on Inflammatory Factors" (International Journal of Urology, 2020, 40(6):979-982.) A method of...

Claims

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Application Information

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IPC IPC(8): A61K9/54A61K47/04A61K33/04A61K41/00A61K45/06A61P35/00A61P35/02A61P39/06A61P37/04A61P31/04A61P31/10A61P17/02A61K8/23A61K8/25A61K8/02A61Q19/00A61Q19/08
CPCA61K9/5115A61K9/5192A61K33/04A61K41/0052A61K45/06A61P35/00A61P35/02A61P39/06A61P37/04A61P31/04A61P31/10A61P17/02A61K8/23A61K8/25A61K8/0245A61Q19/00A61Q19/08A61K2800/413A61K2300/00
Inventor 杨博宇
Owner BEIJING FRIENDSHIP HOSPITAL CAPITAL MEDICAL UNIV
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