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Nifuratel nystatin soft capsule and preparation method thereof

A nifuratel technology for producing fungi and nifuratel, which is applied in the field of medicine, can solve problems such as vaginal irritation, vaginal dryness, burning sensation, etc., and achieve the effect of reducing irritation

Inactive Publication Date: 2021-08-10
哈尔滨海涵丰生物科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The drug will have local irritation to the vagina, and may cause burning sensation, vaginal dryness, or nausea and other adverse reactions in the gastrointestinal tract

Method used

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  • Nifuratel nystatin soft capsule and preparation method thereof
  • Nifuratel nystatin soft capsule and preparation method thereof
  • Nifuratel nystatin soft capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1: Preparation of pharmaceutical preparations

[0033] According to 1000 grain weight, the content group is divided into: nitrate 500g, oxeline 33.4g, olive oil 900g, and medicinal Vaseline 100g. The soft capsule sac group is divided into: gelatin 380g, glycerol 182.4 g, water 380g, 1 g of sunset yellow, 2 g of titanium dioxide, ε-polylysine 8 g.

[0034] According to the above formulation, the operation process:

[0035] (1) Pre-treatment of raw materials, after 120 mesh sieves, weighted the place for the sieve;

[0036] (2) Pharmaceuticals with equivalents of plans, nitrates, and stermycin sequentially add the stirring insulation bucket with olive oil, temperature 40 ° C, stirring speed of 800-1500 rpm, until uniform, spare;

[0037](3) Preparation of soft plastic sac Shell material, 1 will be equivalent to ε-polylysine, sunset yellow, titanium dioxide, and titanium dioxide, grinding with colloid mills, after completion, rinse the rubber grind, collect the grindin...

Embodiment 2

[0048] Example 2: Rabbit vaginal administration irritating experiment

[0049] (1) Experimental group

[0050] Select 24 female experimental rabbits in quarantine, divided into two groups according to the weight of the body weight, 6 in each group.

[0051] Each group is

[0052] (1) placebo group (0.5 g of physiological saline);

[0053] (2) Experimental group (0.5 g of Example 1 soft capsule);

[0054] (3) Control group 1 (0.5 g Comparative Example 1 Soft capsule);

[0055] (4) Control group 2 (0.5 g Comparative Example 2 Soft capsule)

[0056] (2) method of administration

[0057] This test is administered to the experimental rabbit vaginal administration. Each experimental rabbit is bound to the rear limbs on the holder, lift the animal tail exposes the vaginal port, and the amount is administered for each 0.5 g of gel each time. It should be noted that the embodiments and comparative examples are prepared based on the specifications of the human administration, and the soft c...

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PUM

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Abstract

The invention relates to a nifuratel nystatin soft capsule and a preparation method thereof. The content of the soft capsule consists of nifuratel, nystatin, olive oil and medicinal vaseline. The capsule shell of the soft capsule comprises gelatin, glycerol, water and epsilon-polylysine. According to the nifuratel nystatin soft capsule, the formula of the nifuratel nystatin soft capsule is optimized, the olive oil is used for replacing the conventional medicinal soybean oil, and the epsilon-polylysine is used as the preservative so that the irritation of the nifuratel nystatin soft capsule to the vagina is reduced.

Description

Technical field [0001] The present invention belongs to the field of medical technology, and more particularly to a nitratesolamofin soft capsule and a preparation method thereof. Background technique [0002] Nifuratel is a broad-spectrum antibacterial drug, which belongs to furanone (this kind of drug is also furan, furan Date, dysent). Nitrates were launched in the 1960s by Italy, which has been launched in more than 20 countries in more than 20 countries. It has been more than 30 years, and there have been bacteria, trichomonidium and mold, which lead to women's reproductive system infection. Playing strong, effective killing, and rarely produce any urgent, chronic side effects. Due to its multi-faceted therapeutic effects, both vaginitis caused by bacterial, drippers or mold infections are significant. [0003] Formomycin, alfenpric nymatin, is yellow or brown yellow powder, there is a grain odor, strong moisture, unstable light, air, acid and alkali, the aqueous solution is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/7048A61K47/44A61K47/06A61K47/34A61K47/42A61K47/10A61K47/02A61P15/02A61P31/04A61P31/10A61P33/02A61K31/422
CPCA61K9/0034A61K9/4816A61K9/4825A61K9/4833A61K9/4858A61K31/422A61K31/7048A61P15/02A61P31/04A61P31/10A61P33/02A61K2300/00
Inventor 于伟孙雪楠王越王巍金海英
Owner 哈尔滨海涵丰生物科技开发有限公司
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