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A kind of pelvic floor patch for gynecology and preparation method thereof

A patch and pelvic floor technology, applied in the field of gynecology, can solve the problems of unsatisfactory elasticity and low porosity, and achieve the effect of reducing the occurrence of inflammation, excellent mechanical properties, and promoting the reconstruction of the body

Active Publication Date: 2022-03-25
NINGBO FIRST HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

CN105536071A discloses a polylactic acid / polycaprolactone / polypropylene composite pelvic floor patch, the polypropylene patch provides stable mechanical properties, and polylactic acid / polycaprolactone provides better biocompatibility, but this kind The material is not very porous and the elasticity is not ideally affected by the polypropylene
CN107115563A uses a bacterial cellulose patch, which is in the form of a porous network, and is prepared by a freeze-thaw cycle method, which reduces the risk of infection when the patch material is applied and gynecological treatment, but its tension and elasticity are not the same as the desired pelvic floor reconstruction material There is a big gap
Currently, there is no single patch material that meets all the requirements for an ideal pelvic floor reconstruction material

Method used

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  • A kind of pelvic floor patch for gynecology and preparation method thereof
  • A kind of pelvic floor patch for gynecology and preparation method thereof
  • A kind of pelvic floor patch for gynecology and preparation method thereof

Examples

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Effect test

Embodiment 1

[0027] A preparation method of a gynecological pelvic floor patch, comprising the following steps:

[0028] Step 1: prepare a polycitrate-polycaprolactone base layer by electrospinning;

[0029] (1) Preparation of polycitrate prepolymer: citric acid and 1,8-octanediol were added to a container in a molar ratio of 1:1, heated to 160° C. in an oil bath under nitrogen protection, and subjected to Stir until the powder is completely melted; then polymerize at 140° C. and normal pressure for 45 minutes to obtain a crude polycitrate; quickly remove the prepolymer while hot, add ethanol to dissolve the crude polycitrate, and add distilled water to precipitate polycitrate. acid ester, repeated washing several times to completely remove unreacted monomers, so as to obtain relatively pure polycitrate.

[0030] (2) Preparation of electrospinning solution: using trifluoroethanol as a solvent, a mixed solution of polycitrate and PCL was prepared, and the ratio of polycitrate to polycaprol...

Embodiment 2

[0042] A preparation method of a gynecological pelvic floor patch, comprising the following steps:

[0043] Step 1: prepare a polycitrate-polycaprolactone base layer by electrospinning;

[0044] (1) Preparation of polycitrate: add citric acid and 1,8-octanediol to a container in a molar ratio of 1:1, heat to 160°C in an oil bath under nitrogen protection, and stir until powder All melted; then polymerized at 145°C and normal pressure for 50 min to obtain crude polycitrate; quickly remove the crude polycitrate while hot, add ethanol to dissolve it, and add distilled water to precipitate polycitrate, and wash repeatedly for several times. The second step is to completely remove unreacted monomers, thereby obtaining relatively pure polycitrate.

[0045] (2) Preparation of electrospinning solution: using trifluoroethanol as a solvent, a mixed solution of polycitrate and polycaprolactone (PCL) was prepared, and the ratio of polycitrate to polycaprolactone was 5:5.

[0046] (3) El...

Embodiment 3

[0057] A preparation method of a gynecological pelvic floor patch, comprising the following steps:

[0058] Step 1: prepare a polycitrate-polycaprolactone base layer by electrospinning;

[0059] (1) Preparation of polycitrate: add citric acid and 1,8-octanediol to a container in a molar ratio of 1:1, heat to 160°C in an oil bath under nitrogen protection, and stir until powder All melted; then polymerized at 150°C and normal pressure for 50 min to obtain a crude polycitrate; quickly remove the crude polycitrate while hot, add ethanol to dissolve the crude polycitrate, and add distilled water to precipitate the polycitric acid ester, repeated washing several times to completely remove unreacted monomers, so as to obtain relatively pure polycitrate.

[0060] (2) Preparation of electrospinning solution: using trifluoroethanol as a solvent, a mixed solution of polycitrate and polycaprolactone (PCL) was prepared, and the ratio to polycaprolactone was 8:2.

[0061](3) Electrospinn...

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Abstract

The invention discloses a pelvic floor patch for gynecology. The patch is composed of a base layer, a coating and a fiber layer. The base layer is an electrospun layer prepared from polycitrate-polycaprolactone; the base layer is coated Coating, the coating is composed of tussah silk fibroin, chitosan and polypeptide antibacterial agent; the fiber obtained by electrospinning of PLGA-chitosan-collagen mixed solution is arranged on one side of the coating-coated base layer Floor. The pelvic floor patch of the invention has good biocompatibility, excellent mechanical properties and durable antibacterial properties.

Description

technical field [0001] The invention relates to the technical field of gynecology, in particular to a pelvic floor patch for gynecology and a preparation method thereof. Background technique [0002] Pelvic floor dysfunction (PFD) is a gynecological disease with stress urinary incontinence, pelvic organ prolapse and chronic pelvic pain as the main symptoms. It occurs frequently in middle-aged and elderly women and seriously affects the quality of life of patients. Commonly used operations include vaginal hysterectomy, anterior and posterior vaginal wall repairs, etc., which can relieve symptoms to a certain extent, but cannot fundamentally cure the disease. The recurrence rate is higher. In recent years, pelvic floor reconstruction surgery with biological mesh has gradually been widely used in female pelvic floor disorders. A large number of studies have shown that pelvic floor patch is an important pelvic floor tissue substitute, which can replace the weak and damaged pel...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61L27/18A61L27/20A61L27/22A61L27/26A61L27/54A61L27/56A61L27/58A61L27/50D04H1/4382D04H1/728D06N3/00D06N3/12D06N3/18D06N7/00
CPCA61L27/18A61L27/20A61L27/22A61L27/227A61L27/26A61L27/54A61L27/58A61L27/56A61L27/50D04H1/4382D04H1/728D06N3/0011D06N3/186D06N3/0015D06N7/00D06N3/12D06N3/0061A61L2300/232A61L2300/252A61L2300/404A61L2430/34D06N2201/10D06N2209/1671D06N2211/22C08L67/04C08L5/08C08L89/00
Inventor 王霖霖
Owner NINGBO FIRST HOSPITAL
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