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Gynecological pelvic floor patch and preparation method thereof

A patch and pelvic floor technology, applied in the field of gynecology, can solve problems such as unsatisfactory elasticity and low porosity, achieve the effects of reducing inflammation, excellent mechanical properties, and promoting the reconstruction of the body

Active Publication Date: 2021-08-06
NINGBO FIRST HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

CN105536071A discloses a polylactic acid / polycaprolactone / polypropylene composite pelvic floor patch, the polypropylene patch provides stable mechanical properties, and polylactic acid / polycaprolactone provides better biocompatibility, but this kind The material is not very porous and the elasticity is not ideally affected by the polypropylene
CN107115563A uses a bacterial cellulose patch, which is in the form of a porous network, and is prepared by a freeze-thaw cycle method, which reduces the risk of infection when the patch material is applied and gynecological treatment, but its tension and elasticity are not the same as the desired pelvic floor reconstruction material There is a big gap
Currently, there is no single patch material that meets all the requirements for an ideal pelvic floor reconstruction material

Method used

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  • Gynecological pelvic floor patch and preparation method thereof
  • Gynecological pelvic floor patch and preparation method thereof
  • Gynecological pelvic floor patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A preparation method of a pelvic floor patch for gynecology, comprising the steps of:

[0028] Step 1: preparing a polycitrate-polycaprolactone base layer by electrospinning;

[0029] (1) Preparation of polycitrate prepolymer: Add citric acid and 1,8-octanediol into the container at a molar ratio of 1:1, heat to 160°C in an oil bath under the protection of nitrogen, and carry out Stir until the powder is completely melted; then polymerize at 140°C for 45 minutes under normal pressure to obtain the crude polycitrate; quickly remove the prepolymer while hot, add ethanol to dissolve the crude polycitrate, and add distilled water to precipitate polycitrate Ester, repeated washing several times to completely remove unreacted monomers, so as to obtain relatively pure polycitrate.

[0030] (2) Preparation of electrospinning solution: using trifluoroethanol as a solvent, a mixed solution of polycitrate and PCL was prepared, and the ratio of polycitrate and polycaprolactone was...

Embodiment 2

[0042] A preparation method of a pelvic floor patch for gynecology, comprising the steps of:

[0043] Step 1: preparing a polycitrate-polycaprolactone base layer by electrospinning;

[0044] (1) Preparation of polycitrate: Add citric acid and 1,8-octanediol into the container at a molar ratio of 1:1, heat to 160°C in an oil bath under nitrogen protection, and stir it until it becomes powder All melted; then polymerized at 145°C for 50 minutes under normal pressure to obtain the crude polycitrate; quickly remove the crude polycitrate while hot, add ethanol to dissolve in sequence, and add distilled water to precipitate polycitrate, wash repeatedly for several times The second time to completely remove unreacted monomers, so as to obtain relatively pure polycitrate.

[0045] (2) Preparation of electrospinning solution: using trifluoroethanol as a solvent, a mixed solution of polycitrate and polycaprolactone (PCL) was prepared, and the ratio of polycitrate and polycaprolactone w...

Embodiment 3

[0057] A preparation method of a pelvic floor patch for gynecology, comprising the steps of:

[0058] Step 1: preparing a polycitrate-polycaprolactone base layer by electrospinning;

[0059] (1) Preparation of polycitrate: Add citric acid and 1,8-octanediol into a container at a molar ratio of 1:1, heat it to 160°C in an oil bath under nitrogen protection, and stir it to powder All melted; then polymerized at 150°C under normal pressure for 50 minutes to obtain crude polycitrate; quickly remove the crude polycitrate while hot, add ethanol to dissolve the crude polycitrate, and add distilled water to precipitate polycitrate Esters, repeated washing several times to completely remove unreacted monomers, so as to obtain a relatively pure polycitrate.

[0060] (2) Preparation of electrospinning solution: using trifluoroethanol as a solvent, prepare a mixed solution of polycitrate and polycaprolactone (PCL), the ratio of which to polycaprolactone is 8:2.

[0061](3) Electrospinni...

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Abstract

The invention discloses a gynecological pelvic floor patch. The patch is composed of a base layer, a coating and a fiber layer; the base layer is an electrostatic spinning layer prepared from poly citrate-polycaprolactone; the base layer is coated with the coating and the coating is composed of tussah silk fibroin, chitosan and a polypeptide anti-microorganism agent; and the fiber layer is obtained by electrostatic spinning of a PLGA-chitosan-collagen mixed solution arranged on one side of the base layer coated with the coating. The pelvic floor patch has good biocompatibility, excellent mechanical property and lasting anti-microorganism property.

Description

technical field [0001] The invention relates to the technical field of gynecology, in particular to a pelvic floor patch for gynecology and a preparation method thereof. Background technique [0002] Female pelvic floor dysfunction (PFD) is a gynecological disease characterized by stress urinary incontinence, pelvic organ prolapse, and chronic pelvic pain. It occurs frequently in middle-aged and elderly women, and seriously affects the quality of life of patients. Commonly used operations include vaginal hysterectomy, anterior and posterior vaginal wall repair, etc., which can relieve symptoms to a certain extent, but cannot fundamentally cure the disease. Higher recurrence rate. In recent years, pelvic floor reconstruction surgery with biological mesh has gradually been widely used in women with pelvic floor disorders. A large number of studies have shown that pelvic floor mesh is an important pelvic floor tissue replacement, which can replace the weak and damaged pelvic ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/18A61L27/20A61L27/22A61L27/26A61L27/54A61L27/56A61L27/58A61L27/50D04H1/4382D04H1/728D06N3/00D06N3/12D06N3/18D06N7/00
CPCA61L27/18A61L27/20A61L27/22A61L27/227A61L27/26A61L27/54A61L27/58A61L27/56A61L27/50D04H1/4382D04H1/728D06N3/0011D06N3/186D06N3/0015D06N7/00D06N3/12D06N3/0061A61L2300/232A61L2300/252A61L2300/404A61L2430/34D06N2201/10D06N2209/1671D06N2211/22C08L67/04C08L5/08C08L89/00
Inventor 王霖霖
Owner NINGBO FIRST HOSPITAL
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