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Application of plasmalogen to relieving intestinal inflammations

A plasmalogen, intestinal inflammation technology, applied in the field of inflammatory bowel disease drugs, can solve problems such as lack of research on intestinal health, and achieve the effects of reducing expression and improving intestinal barrier disorders

Inactive Publication Date: 2021-08-06
FUTURE FOOD RES INST (NANJING) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Exogenous plasmalogen has also been shown to have various biological activities, which can improve the level of oxidative stress and the development of neurological diseases, but there is still no research on gut health

Method used

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  • Application of plasmalogen to relieving intestinal inflammations
  • Application of plasmalogen to relieving intestinal inflammations
  • Application of plasmalogen to relieving intestinal inflammations

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Embodiment 1: A kind of method for preparing plasmalogen

[0052] 1) Cultivate Bifidobacterium longum: culture in BHI medium in a constant temperature incubator at 37°C for 24 hours, collect the bacteria by centrifugation, lyophilize and vacuum dry, and then pulverize to obtain a powder with a fat content of 17.6%;

[0053] 2) The powder is subjected to subcritical extraction to obtain a phospholipid complex. The specific operating parameters are the ratio of solvent to solid: 1:1-1.5:1; the working pressure of the extraction tank: 0.3-0.8MPa; the extraction temperature: 30-50°C; the extraction time: 30 -60 minutes; separation tank temperature: 50-70 ° C;

[0054] 3) The phospholipid complex is dissolved with n-hexane, the substrate concentration is controlled at 2 g / mL, the amount of enzyme (phospholipase A1, Lectiase Ultra) added is 4%, the amount of water added is 10%, and the reaction temperature is 45 ° C. / min) reaction for 20h, the reaction solution was centrifu...

Embodiment 2

[0057] Example 2: Application of a plasmalogen in alleviating intestinal inflammation

[0058] Using the plasmalogen prepared in Example 1 as a raw material, animal experiments were carried out, and the test methods and results were as follows:

[0059] experimental method:

[0060] Animal grouping and handling:

[0061] Seventy-five C57BL / 6J male mice were randomly divided into normal diet control group (Ctrl), dextran sodium sulfate DSS model group (DSS), microbial source plasmalogen low, medium and high dose group, a total of 5 groups, 15 mice in each group . After one week of adaptive feeding, all the mice started the experiment. On the 1st-7th day, the normal group was given normal drinking water, and the mice in the remaining groups were given 3% DSS solution as drinking water, and the plasmalogen was administrated with microbial source plasmalogen (1, 5, 10mg / kg / day) at the same time, the test On day 8-10, all groups were given normal drinking water, and the experim...

Embodiment 3

[0073] Embodiment 3: A kind of food that has the function of alleviating intestinal inflammation

[0074] A food for relieving intestinal inflammation, the food is a solid beverage, the formula contains plasmalogen, resistant dextrin, inulin, and sodium alginate in a mass ratio of 1:10:5:4.

[0075] The formulation technology of the solid beverage includes: adding auxiliary materials to the plasmalogen to prepare a mixed powder, which is homogenized after adding water; spray drying to obtain a solid beverage (each g powder product contains 50 mg of plasmalogen).

[0076] Using the plasmalogen solid beverage prepared in Example 3 as a raw material, animal experiments were carried out, and the test methods and results were as follows:

[0077] Sixty C57BL / 6J male mice were randomly divided into normal diet control group (Ctrl), DSS model group (DSS), plasmalogen solid drink group, and excipient group, with 15 mice in each group. After one week of adaptive feeding, all the mice ...

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Abstract

The invention discloses application of plasmalogen to relieving intestinal inflammations, and belongs to the technical field of medicines for treating inflammatory bowel diseases. The invention provides application of microorganism-derived plasmalogen to preparation of a food or medicine for relieving or improving intestinal inflammations. Experiments show that the microorganism-derived plasmalogen can significantly alleviate weight losses, increased death rate, colon shortening, increased disease activity index and intestinal pathological changes of DSS-induced mice, and significantly alleviates the intestinal inflammations.

Description

technical field [0001] The invention relates to the application of a plasmalogen in alleviating intestinal inflammation, and belongs to the technical field of inflammatory bowel disease drugs. Background technique [0002] Inflammatory bowel disease (IBD) is a chronic progressive immune-mediated disease characterized by recurrent intestinal inflammation, which has seriously affected intestinal health and quality of life and has become a global health problem. question. At present, there is no cure for IBD at home and abroad. The purpose of current treatment is to reduce the inflammation that causes the disease, so as to provide short-term or long-term relief and reduce the risk of complications, usually including drug therapy (anti-inflammatory drugs, immunosuppressants, biologics agents and antibiotics) or surgery. However, the above methods only relieve some patients (20-35%), and the effect is not ideal. Therefore, inflammatory bowel disease is considered as a disease w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/685A61K9/48A61K45/06A61P1/00C12P7/64A23L33/10A23L33/125A23L33/17A23L2/39
CPCA23L2/39A23V2002/00A61K9/48A61K31/685A61K45/06A23L33/10A23L33/125A23L33/17A61P1/00C12P7/6481A23V2200/32A61K2300/00Y02P20/54
Inventor 徐勇将刘元法刘炎峻
Owner FUTURE FOOD RES INST (NANJING) CO LTD
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