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Surface-coated modified porous calcium phosphate ceramic microspheres and preparation method and application thereof

A technology of porous calcium phosphate and surface coating, applied in the field of medical materials for bone injury repair, can solve the problems of low production efficiency, inconvenience, difficult to control the diameter of the ball and its distribution, etc., to improve expression, improve osteogenic differentiation and/or Angiogenesis ability, the effect of promoting tubulogenesis

Active Publication Date: 2022-07-26
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In summary, porous calcium phosphate bioceramic microspheres with high biological activity on the surface have unique advantages in bone defect repair, but the current technology for preparing porous calcium phosphate bioceramic microspheres has more or less low production efficiency, poor ball diameter and Distribution is difficult to control and many other problems. On this basis, it is even more inconvenient to prepare surface-coated modified porous calcium phosphate bioceramic microspheres by these technologies.

Method used

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  • Surface-coated modified porous calcium phosphate ceramic microspheres and preparation method and application thereof
  • Surface-coated modified porous calcium phosphate ceramic microspheres and preparation method and application thereof
  • Surface-coated modified porous calcium phosphate ceramic microspheres and preparation method and application thereof

Examples

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Effect test

Embodiment 1

[0027] 1) Uniformly mix β-tricalcium phosphate powder, microcrystalline cellulose and polystyrene microsphere pore-forming agent with a median diameter of about 40 μm to obtain a solid phase mixture. The mass fraction of microcrystalline cellulose is 30%, and the volume ratio of pore-forming agent to beta-tricalcium phosphate powder is 1.5:1. A 0.5% methyl cellulose aqueous solution is prepared and slowly added to the solid phase mixture, and a plastic wet material is obtained after uniform mixing, wherein the mass fraction of the binder is 40%.

[0028] 2) Load the plastic wet material obtained in step 1) into the extrusion device of the extrusion spheronizer, and extrude it from an orifice plate with a diameter of 1.5 mm to obtain a bar-shaped cylindrical material; pour the bar-shaped cylindrical material into a spheronizing device, and rolling to obtain microspheres.

[0029] 3) adding magnesium phosphate powder to the microspheres of the spheronizing device in step 2) to ...

Embodiment 2

[0033] 1) Uniformly mix β-tricalcium phosphate powder, microcrystalline cellulose and polystyrene microsphere pore-forming agent with a median diameter of about 40 μm to obtain a solid phase mixture. The mass fraction of microcrystalline cellulose is 30%, and the volume ratio of pore-forming agent to beta-tricalcium phosphate powder is 1.5:1. A 0.5% methyl cellulose aqueous solution is prepared and slowly added to the solid phase mixture, and a plastic wet material is obtained after uniform mixing, wherein the mass fraction of the binder is 40%.

[0034] 2) Load the plastic wet material obtained in step 1) into the extrusion device of the extrusion spheronizer, and extrude it from an orifice plate with a diameter of 1.5 mm to obtain a bar-shaped cylindrical material; pour the bar-shaped cylindrical material into into a spheronizing device, and rolling to obtain microspheres.

[0035] 3) The magnesium phosphate powder is added to the microspheres of the spheronizing device in ...

Embodiment 3

[0039] 1) uniformly mixing hydroxyapatite powder, microcrystalline cellulose and paraffin microsphere pore-forming agent with a median diameter of about 100 μm to obtain a solid phase mixture. The mass fraction of microcrystalline cellulose is 20%, and the volume ratio of pore-forming agent to hydroxyapatite powder is 2:1. A 0.5% methyl cellulose aqueous solution is prepared and slowly added to the solid phase mixture, and a plastic wet material is obtained after uniform mixing, wherein the mass fraction of the binder is 30%.

[0040] 2) Load the plastic wet material obtained in step 1) into the extrusion device of the extrusion spheronizer, and extrude it from an orifice plate with a diameter of 1.5 mm to obtain a bar-shaped cylindrical material; pour the bar-shaped cylindrical material into a spheronizing device, and rolling to obtain microspheres.

[0041] 3) adding the strontium silicate powder to the microspheres of the spheronizing device in step 2) to obtain microspher...

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Abstract

The invention discloses a surface-coated modified porous calcium phosphate ceramic microsphere and a preparation method and application thereof, comprising: 1) uniformly mixing calcium phosphate ceramic powder, an excipient and a pore-forming agent to obtain a solid phase mixture, Add the binder solution into the solid phase mixture and mix evenly to obtain a plastic wet material; 2) Load the plastic wet material into the extrusion device of the extrusion spheronizer to obtain a bar-shaped cylindrical material, and then pour the material into In the spheronization device, the microspheres are obtained by rolling; 3) the bioactive powder is added to the microspheres of the spheronization device to obtain the microspheres coated with bioactive substances; 4) the microspheres are dried and then placed in a sintering furnace for high temperature sintering , to obtain surface-coated modified porous calcium phosphate ceramic microspheres. The size and porous structure of the surface-coated modified porous calcium phosphate ceramic microspheres prepared by the method of the invention can be adjusted, the surface has high biological activity, and has a good application prospect as a bone defect filling and repairing material.

Description

technical field [0001] The invention relates to the technical field of medical materials for repairing bone damage, in particular to a surface-coated modified porous calcium phosphate ceramic microsphere and a preparation method and application thereof. Background technique [0002] Osteoporosis, congenital bone disease or infection, bone tumor and bone defect caused by accidental trauma are major problems of human life and health, and the demand for bone defect filling materials is also increasing day by day. Calcium phosphate ceramics are currently widely used bone filling materials in clinical practice, and are usually used for filling bone defects in the form of blocks or granules. Calcium phosphate ceramic blocks have good integrity and are easy to fill, but most of them are pre-prepared and fixed in shape, making it difficult to match bone defects with complex shapes. In contrast, calcium phosphate ceramic particles can adapt well to irregular and complex-shaped bone ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C04B38/06C04B38/00C04B35/447C04B41/87A61L27/12A61L27/10A61L27/30A61L27/32A61L27/56
CPCC04B38/067C04B38/009C04B38/0645C04B38/0054C04B35/447A61L27/12A61L27/10A61L27/306A61L27/32A61L27/56C04B41/87C04B41/5048C04B41/009C04B41/5027A61L2430/02A61L2300/606A61L2300/412A61L2300/112A61L2300/102
Inventor 叶建东李泽远
Owner SOUTH CHINA UNIV OF TECH
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