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Preparation method and application of modified starch

A technology of modified starch and starch, which is applied in the field of modification and modification of natural polymer materials, can solve the problems of not meeting the production requirements of soft capsules, slow molding speed of wet rubber, poor rupture strength and toughness, etc., to improve the overall reaction efficiency, Increased water holding capacity and transparency, low gelatinization temperature

Active Publication Date: 2021-07-16
SIRIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Generally speaking, the modified starch used in soft capsules still has problems such as high glue viscosity, slow forming speed of wet rubber, poor burst strength and toughness, etc., which still cannot meet the production requirements of soft capsules.

Method used

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  • Preparation method and application of modified starch
  • Preparation method and application of modified starch
  • Preparation method and application of modified starch

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Tapioca starch was prepared into starch milk with a mass fraction of 25% in a reaction kettle, and a magnetically immobilized medium-temperature α-amylase was added in an amount of 6 U / g starch. The reaction temperature was adjusted to 40°C, the pH value was 5, the magnetic field strength was set to 2.0kA / m, supplemented with nitrogen gas at a pressure of 0.5MPa, and the starch was enzymatically hydrolyzed for 2 hours in a fluidized state of continuous circulation. Then adjust the magnetic field strength to 1.0kA / m, lower the temperature to 28°C, and adjust the pH to 10-12; add propylene oxide with a starch mass fraction of 5%, react for 0.5h, then raise the temperature to 40°C, react for 18h, and then add starch milk Add sodium trimetaphosphate with a starch mass fraction of 0.06%, after cross-linking reaction for 2 hours, acid neutralization, dehydration, washing, and drying to obtain a hydroxypropyl content of 1.6g / 100g starch (dry basis), at 95°C 5 The viscosity val...

Embodiment 2

[0064] In the reaction kettle, the potato starch was prepared with water to make starch milk with a mass fraction of 35%, and a magnetically immobilized medium-temperature α-amylase was added in an amount of 7 U / g starch. Adjust the reaction temperature to 55°C, the pH value to 6, set the magnetic field strength to 4.0kA / m, supplemented by nitrogen gas with a pressure of 0.8MPa, so that the starch is enzymatically hydrolyzed for 1.5h in a fluidized state of continuous circulation, and then the magnetic field is adjusted Strength to 1.2kA / m, cool down to 24°C, adjust pH to 10-12; add propylene oxide with a mass fraction of 7% starch, react for 0.8h, then raise the temperature to 38°C, react for 20h, then add starch into the starch milk Phosphorus oxychloride with a mass fraction of 0.06%, after 5 hours of crosslinking reaction, acid neutralization, dehydration, washing, and drying to obtain hydroxypropyl content of 2.5g / 100g starch (dry basis), 5% starch paste at 95°C A compoun...

Embodiment 3

[0066]In the reaction kettle, cornstarch was prepared with water to make starch milk with a mass fraction of 45%, and a magnetically immobilized medium-temperature α-amylase was added in an amount of 8 U / g starch. Adjust the reaction temperature to 70°C, the pH value to 7, set the magnetic field strength to 6.0kA / m, supplemented by nitrogen gas with a pressure of 1.2MPa to make the starch undergo enzymatic hydrolysis for 1 hour in a fluidized state of continuous circulation, and then adjust the magnetic field strength to 1.8kA / m, lower the temperature to 20°C, and adjust the pH to 10-12; add propylene oxide with a starch mass fraction of 10%, react for 1 hour, then raise the temperature to 36°C, react for 22 hours, and then add starch mass fraction to the starch milk 0.06% sodium hexametaphosphate, after 8 hours of cross-linking reaction, acid neutralization, dehydration, washing, and drying to obtain hydroxypropyl content of 3.3g / 100g starch (dry basis), viscosity of 5% starch...

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Abstract

The invention relates to a preparation method and an application of modified starch, and belongs to the technical field of modification of natural polymer materials. The invention discloses a continuous preparation process for strengthening starch composite denaturation by using a magnetic field and an application of the continuous preparation process. The method comprises the following steps: carrying out magnetic immobilized enzyme enzymolysis, etherification and cross-linking reaction on natural starch under the action of a magnetic field, dehydrating, washing and drying. According to the preparation process, amylase can be recycled, the energy consumption is reduced, and the production efficiency is improved. The obtained modified starch has the characteristics of low gelatinization temperature and peak viscosity, good film-forming property, high gelation speed and good freeze-thaw stability, and can be applied to the fields of foods, medicines and dietary health-care products as a capsule wall material.

Description

technical field [0001] The invention belongs to the technical field of modification of natural polymer materials, and in particular relates to a preparation method of modified starch and its application in soft capsules. Background technique [0002] Soft capsules are widely used in dietary health products and pharmaceutical industries due to their high bioavailability, easy swallowing and human absorption, good stability of functional substances, ability to mask the unpleasant taste of drugs, easy storage and portability, and neat appearance. . However, in order to effectively avoid the spread of mad cow disease and the occurrence of poisoned capsule incidents, and to meet the consumption needs of people with special religious beliefs and vegetarians, non-gelatin vegetable soft capsules have gradually become a research hotspot in recent years. Starch is a plant polysaccharide environmental protection material that widely exists in nature. It has a wide range of sources, ri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B31/00C08B30/12C08B31/12A61K9/48A61K47/36C09D103/08C09D7/63
CPCC08B31/003C08B31/12C08B30/12A61K9/4816C09D103/08C09D7/63C08K5/053Y02A50/30
Inventor 陈琼邱碧霞李绪发杨旭腾
Owner SIRIO PHARMA CO LTD
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