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High-strength polylactic acid-based electrospun nanofiber membrane and preparation method thereof

An electrospinning nanofiber, polylactic acid-based technology, applied in spinning solution preparation, textiles and papermaking, non-woven fabrics, etc., can solve the problem of affecting the biocompatibility of polylactic acid, enhance the content of nano-fillers, and increase the strength by a small margin. and other problems, to achieve the effect of saving dissolution time, good dispersibility, and small reduction in elongation at break

Pending Publication Date: 2021-06-18
徐州工牛高新材料有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the current problems of electrospun polylactic acid nanofiber membranes with small strength improvement, high content of reinforced nanofillers, and affecting the biocompatibility of polylactic acid, the present invention provides a high-strength polylactic acid-based electrospun nanofiber membrane. Preparation

Method used

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  • High-strength polylactic acid-based electrospun nanofiber membrane and preparation method thereof
  • High-strength polylactic acid-based electrospun nanofiber membrane and preparation method thereof
  • High-strength polylactic acid-based electrospun nanofiber membrane and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0031] 1) Preparation of polylactic acid / cellulose nanocrystal spinning solution: Dissolve cellulose nanocrystals in a mixed solvent with a volume ratio of chloroform and acetone of 1:1 to configure the solution, and dissolve polylactic acid in chloroform and acetone with a volume ratio of Configure the solution in a 1:1 mixed solvent. After the cellulose nanocrystals are uniformly dispersed and the polylactic acid is completely dissolved, the above two solutions are mixed. After stirring evenly, the mass ratio of modified cellulose nanocrystals and polylactic acid is 0.5: 100 of electrospinning solution, and keep the concentration of polylactic acid in the mixed solution at 10wt%.

[0032]2) The electrospinning process of the spinning solution: the polylactic acid / modified cellulose nanocrystal spinning solution prepared in step 2) is placed in a fume hood for electrospinning, and the configured spinning solution is loaded into a syringe , the spinning voltage is set to 18kV,...

Embodiment 2

[0034] 1) Preparation of polylactic acid / cellulose nanocrystal spinning solution: Dissolve cellulose nanocrystals in a mixed solvent with a volume ratio of chloroform and acetone of 1:1 to configure the solution, and dissolve polylactic acid in chloroform and acetone with a volume ratio of Configure the solution in a 1:1 mixed solvent. After the cellulose nanocrystals are uniformly dispersed and the polylactic acid is completely dissolved, the above two solutions are mixed. After stirring evenly, the mass ratio of modified cellulose nanocrystals and polylactic acid is 1: 100 of electrospinning solution, and keep the concentration of polylactic acid in the mixed solution at 10wt%.

[0035] 2) The electrospinning process of the spinning solution: the polylactic acid / modified cellulose nanocrystal spinning solution prepared in step 2) is placed in a fume hood for electrospinning, and the configured spinning solution is loaded into a syringe , the spinning voltage is set to 18kV, ...

Embodiment 3

[0037] 1) Preparation of polylactic acid / cellulose nanocrystal spinning solution: Dissolve cellulose nanocrystals in a mixed solvent with a volume ratio of chloroform and acetone of 1:1 to configure the solution, and dissolve polylactic acid in chloroform and acetone with a volume ratio of Configure the solution in a 1:1 mixed solvent. After the cellulose nanocrystals are uniformly dispersed and the polylactic acid is completely dissolved, the above two solutions are mixed. After stirring evenly, the mass ratio of modified cellulose nanocrystals and polylactic acid is 3: 100 of electrospinning solution, and keep the concentration of polylactic acid in the mixed solution at 10wt%.

[0038] 2) The electrospinning process of the spinning solution: the polylactic acid / modified cellulose nanocrystal spinning solution prepared in step 2) is placed in a fume hood for electrospinning, and the configured spinning solution is loaded into a syringe , the spinning voltage is set to 18kV, ...

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Abstract

The invention discloses a high-strength polylactic acid-based electrospun nanofiber membrane and a preparation method thereof. The high-strength electrostatic spinning nanofiber membrane comprises polylactic acid matrix resin and a reinforced nanofiller; the reinforced nanofiller is modified cellulose nanocrystal, and the preparation method of the modified cellulose nanocrystal comprises the following steps of firstly, oxidizing cellulose nanocrystal TEMPO and then introducing carboxyl; and reacting the processed cellulose nanocrystal with aminated polyethylene glycol under the dehydration condensation action of 1-ethyl-3-[3-dimethylaminopropyl] carbodiimide and N-hydroxysuccinate, so as to obtain the modified cellulose nanocrystal. The preparation method of the electrostatic spinning nanofiber membrane comprises the following steps of preparing a polylactic acid solution and a modified cellulose nanocrystal solution which are dissolved in a mixed solvent of chloroform / acetone (the volume ratio is 1: 1), and mixing the polylactic acid solution and the modified cellulose nanocrystal solution according to a certain proportion to prepare a mixed spinning solution with different modified cellulose nanocrystal contents; and then preparing the corresponding high-strength nanofiber membrane by adopting an electrostatic spinning technology. Compared with a pure polylactic acid fiber membrane, the polylactic acid / modified cellulose nanocrystal fiber membrane has the advantages that the tensile strength is obviously improved, the elongation at break is still kept to be slightly reduced, the product is biodegradable, the preparation method is simple, the cost is low, the control is easy, and the polylactic acid / modified cellulose nanocrystal fiber membrane has a wide application prospect in the fields of biomedicine and the like.

Description

technical field [0001] The invention belongs to the field of preparation of electrospun nanofibers, and in particular relates to a high-strength polylactic acid-based electrospun nanofiber membrane and a preparation method thereof. Background technique [0002] Polylactic acid material is currently the most promising green biodegradable thermoplastic resin for development and application. Due to its excellent biodegradability and biocompatibility, it has received extensive attention in the field of biomedical engineering, such as tissue engineering scaffolds, drug delivery, etc. So far, a variety of techniques have been reported to prepare PLA-based tissue engineering scaffold materials, such as solvent casting, particle leaching, membrane layering, injection molding and extrusion, among which PLA fibers prepared by electrospinning The scaffold has a higher porosity and a larger specific surface area, which can provide a larger surface for cell growth, and the structural mo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D04H1/435D04H1/728D04H1/413D01D1/02
CPCD04H1/435D04H1/728D04H1/413D01D1/02
Inventor 况太荣陈舟李甲铎李辉季国靖
Owner 徐州工牛高新材料有限公司
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