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Preparation and application of carbon dots for detecting progesterone

A progesterone and carbon dot technology, applied in the field of nanomaterials, can solve the problems of long sample pretreatment time, low sensitivity, long running time, etc., and achieve the effect of good analysis and monitoring ability, broad application prospect and high luminous intensity.

Pending Publication Date: 2021-06-04
北京国科华仪科技有限公司
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Problems solved by technology

[0003] Methods for detecting progesterone include chromatographic analysis, colorimetry, electrochemical methods, etc. However, these methods have certain disadvantages, such as long sample pretreatment time, expensive reagents, long running time, and low sensitivity

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  • Preparation and application of carbon dots for detecting progesterone
  • Preparation and application of carbon dots for detecting progesterone
  • Preparation and application of carbon dots for detecting progesterone

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Embodiment Construction

[0018] A preparation for detecting the carbon point of progesterone is as follows. Weigh 0.5g (permissible range 0.1~2g) of curcumin into a beaker and heat it in a muffle furnace at 180°C (permissible range 170~190°C) for 6 hours, a brown substance was obtained. After the reactor was naturally cooled to room temperature, it was dissolved in an ethanol solvent and centrifuged at 10,000 rpm for 30 minutes, followed by dialysis with a dialysis bag to remove unreacted small molecules. Finally, solid product carbon dot CDs were obtained by freeze-drying method.

[0019] The optical properties of carbon dot CDs prepared by the above preparation method are:

[0020] Such as figure 1 As shown, the maximum excitation wavelength of carbon dots is at 410nm, and the maximum emission peak is at 560nm.

[0021] The fluorescent carbon dot CDs prepared by the above preparation method are used for the detection of progesterone as follows,

[0022] First, progesterone solutions with differe...

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Abstract

The invention relates to preparation and application of carbon dots for detecting progesterone, and belongs to the technical field of nanomaterials, the preparation method comprises the following steps: 1, weighing 0.1-2g of curcumin, putting the curcumin into a beaker, and heating the curcumin in a muffle furnace for 6 hours at 170-190 DEG C to obtain a brown substance; 2, after the brown substance obtained in the step 1 is naturally cooled to room temperature, dissolving the brown substance in an ethanol solvent, centrifuging at 10000 rpm for 30 minutes, and dialyzing by adopting a dialysis bag to remove unreacted small molecules so as to obtain a carbon dot solution; and 3, preparing the carbon dot solution obtained in the step 2 into a solid product carbon dot CDs by adopting a freeze-drying method. The method has the advantages of high efficiency and sensitivity of a fluorescence detection method as well as good stability and high luminous intensity of the carbon dots, and has a wide application prospect in the field of progesterone specificity monitoring.

Description

technical field [0001] The invention belongs to the technical field of nanomaterials, in particular to an application research on progesterone detection based on fluorescent carbon dots. Background technique [0002] Progesterone (P4) is a steroid hormone secreted by the ovary, which plays a vital role in maintaining and regulating physiological processes such as female menstrual cycle, embryonic development, pregnancy and breast development, and is also used in human medicine and clinical treatment is also widely used. However, the abuse of progesterone may cause adverse side effects such as weakness, depression, breast discomfort, certain potential carcinogenic effects, etc. Sensitivity analysis of progesterone monitoring has high requirements in clinical medicine, animal husbandry and environmental protection. Therefore, it is of great significance to detect progesterone efficiently and sensitively. [0003] Methods for detecting progesterone include chromatographic an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/65B82Y20/00B82Y40/00C01B32/15G01N21/64
CPCB82Y20/00B82Y40/00C09K11/65C01B32/15G01N21/6428G01N2021/6439
Inventor 祁洪涛
Owner 北京国科华仪科技有限公司
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