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A kind of biological polyurethane and its preparation method and application

A polyurethane, bio-based technology, applied in the field of polyurethane, can solve the problems of difficult to control the degradation time, the comprehensive performance of porous sponge materials is not ideal, the degradability and biocompatible sponge properties are difficult to take into account, etc., and achieve good degradability. , ideal biocompatibility, ideal mechanical properties

Active Publication Date: 2022-06-21
湖北世丰新材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the overall performance of polyurethane porous sponge materials is still not ideal.
The main disadvantages are that it is difficult to balance the degradability, biocompatibility and various properties of the sponge, and the degradation time is difficult to control

Method used

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  • A kind of biological polyurethane and its preparation method and application
  • A kind of biological polyurethane and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0032] S1. The reaction raw materials are placed in a vacuum drying box, vacuum dried at 80°C for 12 hours, and then stored in a glove box under nitrogen atmosphere, during which the entry of moisture in the air is strictly prevented;

[0033] S2. Place 1 mol of 1,3,5-benzenetrimethanol and 3.1 mol of p-phenylenediisocyanate in an appropriate amount of anhydrous toluene solvent, in 1,3,5-benzenetrimethanol 1wt% dibutyltin dilaurate Under the system of , heating to 70 ℃ for reaction, the reaction time is 1h, and the prepolymer is obtained;

[0034] S3. Add 1.8 mol of threonine and 0.21 mol of polyethylene glycol monomethyl ether to the above prepolymer, heat to 70 ° C for reaction, the reaction time is 1 h, after evaporating the solvent to dryness, the product bio-based polyurethane 1 is obtained, Its number average molecular weight is about 17200 g / mol.

preparation example 2

[0036] S1. The reaction raw materials are placed in a vacuum drying box, vacuum dried at 80°C for 12 hours, and then stored in a glove box under nitrogen atmosphere, during which the entry of moisture in the air is strictly prevented;

[0037] S2. Place 1 mol of 1,3,5-benzenetrimethanol and 3.08 mol of methylcyclohexyl diisocyanate in an appropriate amount of anhydrous toluene solvent, in 1,3,5-benzenetrimethanol 1wt% dilauric acid Under the system of dibutyltin, the reaction is heated to 70 °C, and the reaction time is 1 h to obtain a prepolymer;

[0038] S3. Add 2.1 mol of serine and 0.15 mol of polyethylene glycol monomethyl ether to the above prepolymer, heat to 90 ° C for reaction, the reaction time is 3 h, after evaporating the solvent to dryness, the product bio-type polyurethane 2 is obtained. The average molecular weight is about 17000 g / mol.

preparation example 3

[0040] S1. The reaction raw materials are placed in a vacuum drying box, vacuum dried at 80°C for 12 hours, and then stored in a glove box under nitrogen atmosphere, during which the entry of moisture in the air is strictly prevented;

[0041] S2. Place 1 mol of 1,3,5-benzenetrimethanol and 2.10 mol of methylcyclohexyl diisocyanate in an appropriate amount of anhydrous toluene solvent, in 1,3,5-benzenetrimethanol 1wt% diacetic acid diacetate Under the system of butyl tin, the reaction is heated to 80 °C, and the reaction time is 2 h to obtain a prepolymer;

[0042] S3. Add 1.9 mol of tyrosine, 0.19 mol of polyethylene glycol monomethyl ether, and 1.0 mol of methylcyclohexyl diisocyanate to the above prepolymer, heat to 80 ° C for reaction, the reaction time is 2 h, steam After drying the solvent, the product biotype polyurethane 3 was obtained, and its number average molecular weight was about 18300 g / mol.

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Abstract

The present invention relates to a kind of biotype polyurethane, and the raw material of described biotype polyurethane comprises 1,3,5-benzenetrimethanol, diisocyanate, hydroxyl-containing amino acid, polyethylene glycol monomethyl ether; Wherein, in the diisocyanate The number of moles of isocyanate groups is greater than the sum of the number of moles of hydroxyl and carboxyl groups in the 1,3,5-benzenetrimethanol, amino acid, and polyethylene glycol monomethyl ether. The present invention also includes the preparation method of the biological polyurethane and its application in the field of polyurethane porous sponge. The advantages of the bio-polyurethane are: (1) high flexibility and good degradability; (2) ideal biocompatibility; (3) the resulting bio-polyurethane is subsequently foamed with water The biological polyurethane porous sponge formed by the reaction has uniform and dense cells, high porosity, and ideal mechanical properties.

Description

technical field [0001] The invention belongs to the field of polyurethane, and in particular relates to a biological polyurethane and a preparation method and application thereof. Background technique [0002] As a special class of functional materials, biomaterials are generally in direct contact with the physiological system and act. Physiological systems include both in vivo physiological environments, such as blood, tissue and cells, and in vitro physiological environments, such as cell culture dishes and cell-culture fluid systems in bioreactors. Biomaterials can be natural biomaterials, that is, materials formed in the process of life, such as structural proteins (collagen fibers, silk, etc.) and biominerals (bone, teeth, shells, etc.); they can also be synthesized by physical or chemical methods. Or modified materials, and then processed into biological products. Biomaterials generally need to meet two characteristics: one is functionality, that is, it can diagnose,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G18/10C08G18/66C08G18/48C08G18/32C08G18/34C08G101/00
CPCC08G18/10C08G18/6692C08G18/6674C08G18/3215C08G18/34C08G18/348C08G18/4833
Inventor 罗宇仙
Owner 湖北世丰新材料有限公司
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