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Bismuth-based nano heterojunction material as well as preparation method and application thereof

A heterojunction, nanotechnology, applied in nanotechnology, nanotechnology, nanomedicine, etc., can solve problems such as poor tissue penetration, large organ damage, and difficulty in applying clinical treatment.

Active Publication Date: 2021-06-04
NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the limitation of the band gap of semiconductor materials, it often needs to rely on ultraviolet light to excite the properties of materials, so it will cause great damage to normal tissues and organs, poor tissue penetration ability and difficult to apply in clinical treatment.

Method used

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  • Bismuth-based nano heterojunction material as well as preparation method and application thereof
  • Bismuth-based nano heterojunction material as well as preparation method and application thereof
  • Bismuth-based nano heterojunction material as well as preparation method and application thereof

Examples

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preparation example Construction

[0045] The present invention provides a method for preparing bismuth-based nano-heterojunction materials described in the above technical solution, comprising the following steps:

[0046] The bismuth oxychloride nanoparticle dispersion liquid and the selenosulfate solution are mixed, and hydrothermal reaction is carried out to obtain the bismuth-based nano-heterojunction material.

[0047] In the present invention, the bismuth oxychloride nanoparticles are prepared according to the following method:

[0048] Mixing bismuth salt, transition metal chloride and solvent, solvothermal reaction, and ultraviolet irradiation to obtain bismuth oxychloride nanoparticles;

[0049] The temperature of the solvothermal reaction is 100-180° C.; the time of the solvothermal reaction is 4-18 hours.

[0050] Described bismuth salt is selected from Bi(NO 3 ) 3 、 Bi 2 (SO 4 ) 3 , Bi(NO 3 ) 3 ·5H 2 O, Bi(PO 3 ) 3 、BiH(PO 3 ) 2 、BiH 2 PO 3 and Bi 2 (CO 3 ) 3 at least one of the ...

Embodiment 1

[0095] Example 1 Preparation of black bismuth oxychloride and bismuth selenide nano-heterojunction materials

[0096] (1) Weigh 0.972gBi(NO 3 ) 3 ·5H 2 O in a 50ml beaker, to which 15ml ethylene glycol was added, stirred on a magnetic stirrer until Bi(NO 3 ) 3 Dissolve and disperse evenly to obtain solution a;

[0097] (2) Weigh 0.541gFeCl 3 ·6H 2 O in a 50ml beaker, add 15ml of ultrapure water to it, stir on a magnetic stirrer until FeCl 3 Dissolve and disperse evenly to obtain solution b;

[0098] (3) At room temperature (25°C), all of the above solution b was added dropwise to solution a, and magnetically stirred until the solution became a white suspension to obtain solution c;

[0099] (4) Transfer the c solution into a polytetrafluoroethylene liner, put it into a reactor and seal it, put the reactor into an oven, and react at a constant temperature of 160°C for 12 hours;

[0100] (5) After the reaction is completed, the reaction kettle is cooled to room temperat...

Embodiment 2

[0110] Example 2 Preparation of gray bismuth oxychloride and bismuth selenide nano-heterojunction materials

[0111] (1) Weigh 0.972gBi(NO 3 ) 3 ·5H 2 O in a 50ml beaker, to which 15ml ethylene glycol was added, stirred on a magnetic stirrer until Bi(NO 3 ) 3 Dissolve and disperse evenly to obtain solution a;

[0112] (2) Weigh 0.541gFeCl 3 ·6H 2 O in a 50ml beaker, add 15ml of ultrapure water to it, stir on a magnetic stirrer until FeCl 3 Dissolve and disperse evenly to obtain solution b;

[0113] (3) At room temperature (25°C), all of the above solution b was added dropwise to solution a, and magnetically stirred until the solution became a white suspension to obtain solution c;

[0114] (4) Transfer the c solution into a polytetrafluoroethylene liner, put it into a reactor and seal it, put the reactor into an oven, and react at a constant temperature of 160°C for 12 hours;

[0115] (5) After the reaction is completed, the reaction kettle is cooled to room temperatu...

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Abstract

The invention provides a bismuth-based nano heterojunction material as well as a preparation method and application thereof. The bismuth-based nano heterojunction material comprises bismuth oxychloride nano particles and bismuth selenide nano particles; and heterojunctions are formed between the bismuth oxychloride nano particles and the bismuth selenide nano particles. The bismuth oxychloride nano particles in the bismuth-based nano heterojunction material realize photodynamic therapy and photothermal therapy, and the bismuth selenide nano particles realize photothermal therapy, so that the material has a combined therapy mode of photothermal therapy and photodynamic therapy. The nano material is applied to tumor phototherapy, and has the advantages of good dispersibility in water, low biotoxicity and excellent crystallization performance, so that the nano material has excellent cancer treatment performance and has the capability of reducing toxic and side effects.

Description

technical field [0001] The invention belongs to heterojunction materials, in particular to a bismuth-based nano-heterojunction material and its preparation method and application. Background technique [0002] Semiconductor nanomaterials are one of the candidate materials for constructing new and efficient tumor treatment platforms, and are often used in photothermal therapy and photodynamic therapy of light-excited materials. However, due to the limitation of the band gap of semiconductor materials, it often needs to rely on ultraviolet light to stimulate the properties of materials, so it will cause great damage to normal tissues and organs, poor tissue penetration ability and difficult to apply in clinical treatment. [0003] In recent years, preparation methods such as doping and constructing heterojunctions have been widely used to optimize the energy band structure of semiconductor materials. Doping or the reduction of the bandgap of heterojunction materials or the re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/51A61K47/30A61K33/245A61P35/00B82Y5/00B82Y20/00B82Y30/00B82Y40/00C01B19/00C01G29/00
CPCA61K41/0052A61K9/513A61P35/00A61K33/245B82Y5/00B82Y30/00B82Y40/00B82Y20/00C01B19/007C01G29/00C01P2004/80C01P2004/64C01P2004/62C01P2004/20C01P2004/04C01P2004/03C01P2002/72C01P2002/82
Inventor 吴爱国胡嘉鹏陈天翔林杰房倩兰马雪华
Owner NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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