Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of antibacterial and antifouling polymer brush and its preparation method and application

A polymer brush and antifouling technology, applied in the field of biomedical antibacterial materials, can solve the problems of complicated preparation methods, harsh conditions, and antibacterial activity to be improved, and achieve the effect of easy-to-obtain raw materials, mild synthesis conditions, and good antibacterial effect

Active Publication Date: 2022-05-20
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation methods of the existing antibacterial and antifouling polymer brushes are relatively complicated, the conditions are harsh, and the antibacterial activity needs to be improved.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of antibacterial and antifouling polymer brush and its preparation method and application
  • A kind of antibacterial and antifouling polymer brush and its preparation method and application
  • A kind of antibacterial and antifouling polymer brush and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] (1) Surface treatment of solid: Ultrasonic the glass sheet (referred to as Glass) in deionized water and ethanol successively for 60 minutes, N 2 Blow-dry in the air, then treat in the prepared piranha lotion (concentrated sulfuric acid: 30% hydrogen peroxide=7:3) for 6 hours, introduce hydroxyl groups on the solid surface, rinse with a large amount of water, N 2 Blow dry in air;

[0053] (2) Grafted silane coupling agent: immerse the solid that introduces the hydroxyl group into a toluene solution of 5% 3-aminopropyl-triethoxysilane (APTES), incubate overnight at 15-25°C, and then Washed three times with toluene, ethanol, deionized water and 2 Blow dry in the atmosphere to obtain the solid modified by silane coupling agent, which is recorded as Glass-APTES (XPS spectrogram such as figure 2 shown);

[0054] (3) Grafted polyethylene glycol: Weigh 10 mg of PEG-1K (molecular weight 1000), 7.7 mg of NHS, and 4.6 mg of EDC, mix them in MES buffer, stir at 15-25 °C for 30...

Embodiment 2

[0059] (1) Surface treatment of solids: Ultrasonic the glass sheet successively in deionized water and ethanol for 60 minutes, N 2 Blow dry in the atmosphere, then use oxygen plasma to treat the cleaned glass sheet for 30 seconds, introduce hydroxyl groups on the surface of the glass sheet, rinse with a large amount of water, N 2 Blow dry in air;

[0060] (2) Grafted silane coupling agent: Submerge the glass slide introduced with hydroxyl group in a toluene solution with a concentration of 2% 3-aminopropyl-triethoxysilane, incubate overnight at 15-25°C, and wash with toluene in turn , ethanol, deionized water three times and in N 2 Blow dry in the air to obtain a glass flake modified by a silane coupling agent;

[0061] (3) Grafting polyethylene glycol: Weigh 10 mg of PEG-1K, 7.7 mg of NHS, and 4.6 mg of EDC, mix them in MES buffer, stir at 15-25°C for 30 minutes, and mix the silane coupling agent modified The glass piece is submerged in the mixed solution, shaken for 24 ho...

Embodiment 3

[0065] (1) Surface treatment of solids: Ultrasonic the glass sheet successively in deionized water and ethanol for 60 minutes, N 2 Blow-dry in the air, then treat in the prepared piranha lotion (concentrated sulfuric acid: 30% hydrogen peroxide=7:3) for 6 hours, introduce hydroxyl groups on the surface of the glass sheet, rinse with a large amount of water, N 2 Blow dry in air;

[0066] (2) Grafted silane coupling agent: Submerge the glass slide introduced with hydroxyl group in a toluene solution with a concentration of 2% 3-aminopropyl-triethoxysilane, incubate overnight at 15-25°C, and wash with toluene in turn , ethanol, deionized water three times and in N 2 Blow dry in the air to obtain a glass flake modified by a silane coupling agent;

[0067] (3) Grafted polyethylene glycol: Weigh 5 mg of PEG (molecular weight 467.5), 7.7 mg of NHS, and 4.6 mg of EDC, mix them in MES buffer, stir for 30 min at 15-25 ° C, and couple the silane The agent-modified glass piece is immer...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
concentrationaaaaaaaaaa
Login to View More

Abstract

The invention discloses an antibacterial and antifouling polymer brush as well as a preparation method and application thereof. The polymer brush is formed by a conjugate of polyethylene glycol and a polypeptide, wherein one end of the polyethylene glycol is fixed on a solid surface; the polypeptide is composed of 3-6 hydrophobic amino acids; the hydrophobic amino acid is selected from leucine one or more of acid, phenylalanine, valine, and isoleucine. The antibacterial and antifouling polymer brush of the present invention combines polypeptide and polyethylene glycol, which not only endows the solid surface with antibacterial performance, but also has obvious antifouling effect. Compared with ordinary antibiotics, the antibacterial and antifouling polymer brush of the present invention does not produce drug resistance while being antibacterial, and is suitable for various solid surfaces, has wide applicability, and has a wide range of applications in biomedical materials. Application prospects.

Description

technical field [0001] The invention relates to the field of biomedical antibacterial materials, in particular to an antibacterial and antifouling polymer brush and its preparation method and application. Background technique [0002] BAI (biomedical device-associated infection) has always been an important problem in surgical transplantation. BAI not only brings physical and psychological pain and stress to patients, leading to complications, replacement or removal of implants, etc., but also a heavy burden on the health care system. Especially for Gram-negative bacteria, which cannot be easily eradicated by antibiotics, they are the main source of infection in indwelling medical devices. At present, the main clinical indwelling equipment (such as catheters, ventilators, etc.) has no surface that can effectively prevent equipment-related infections. An ideal antibacterial surface should have an antifouling layer on the surface of the equipment to reduce bacterial contamin...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C08G65/333C08G65/336C07K1/10C07K1/107
CPCC08G65/336C08G65/33396C07K1/10C07K1/1077
Inventor 牛忠伟徐单单
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com