Application of cyclodextrin-metal organic framework in preparation of inhalant and inhalant

A technology of metal-organic framework and cyclodextrin, which is applied in the field of medicine, can solve the problems of restricting the precise delivery of drugs in the lungs, restricting the development of drug delivery systems in the lungs, and poor porosity uniformity, so as to achieve good aerodynamic behavior and good drug delivery. Pulmonary delivery efficiency, the effect of uniform and orderly pores

Pending Publication Date: 2021-06-01
GUANGZHOU NEWORLD PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, existing studies mainly use recrystallization method, salt filtration method, osmotic pressure method, and heat-sensitive agent pore-causing methods to prepare porous carriers. precise delivery of
The lag in the development of pulmonary drug delivery carriers severely limits the development of pulmonary drug delivery systems, and it is urgent to develop a new type of pulmonary drug delivery carrier with high effective deposition rate in the lungs and good aerodynamic performance

Method used

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  • Application of cyclodextrin-metal organic framework in preparation of inhalant and inhalant
  • Application of cyclodextrin-metal organic framework in preparation of inhalant and inhalant
  • Application of cyclodextrin-metal organic framework in preparation of inhalant and inhalant

Examples

Experimental program
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Effect test

Embodiment 1

[0049] The preparation of the cyclodextrin-metal organic framework (KET-CD-MOF) dry powder inhaler of embodiment 1 load ketoprofen

[0050] γ-cyclodextrin and potassium hydroxide were 32.4mg·mL -1 and 11.2mg·mL -1 The concentration is dissolved in 50mL deionized water, and after the two are completely dissolved, filter through a 0.8μm filter membrane. Then add 30mL ketoprofen methanol solution (20mg·mL -1 ), transferred to a 50°C water bath and heated for 0.5h. Then add 30mL of methanol and cetyltrimethylammonium bromide (the concentration after adding is 2mg·mL -1 ), cetyltrimethylammonium bromide was completely dissolved and allowed to stand at room temperature for 2h. Finally, the ketoprofen-loaded cyclodextrin-metal-organic framework (KET-CD-MOF) was collected by centrifugation (rotating speed: 4000 rpm, centrifugation time: 5 min), washed with isopropanol, and the obtained solid was vacuum-dried overnight.

[0051] The PXRD pattern of the prepared cyclodextrin-metal ...

Embodiment 2

[0052] Example 2 Preparation of Cyclodextrin-Metal Organic Framework Dry Powder Inhalation Packed with Curcumin

[0053] γ-cyclodextrin and potassium hydroxide were 32.4mg·mL -1 and 11.2mg·mL -1 The concentration is dissolved in 50mL deionized water, and after the two are completely dissolved, filter through a 0.8μm filter membrane. Then add 35mL mass concentration to the filtrate to be 6.67mg·mL -1 Curcumin methanol solution, moved into a 50°C water bath and heated for 0.5h. Then add 75mL of methanol and cetyltrimethylammonium bromide (the concentration after adding is 2mg·mL -1 ), cetyltrimethylammonium bromide was completely dissolved and allowed to stand at room temperature for 2h. Finally, the curcumin-loaded cyclodextrin-metal-organic framework (Cur-CD-MOF) was collected by centrifugation (rotating speed: 4000 rpm, centrifugation time: 5 min), washed with isopropanol, and the solid was vacuum-dried overnight.

[0054] Please refer to figure 2 (Powder X-ray diffrac...

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Abstract

The invention relates to application of a cyclodextrin-metal organic framework in preparation of an inhalant and the inhalant. According to the invention, cyclodextrin-metal organic frameworks (CD-MOFs) are found to be used as a carrier for preparing the inhalant for the first time, and the obtained inhalant has high lung effective deposition rate, good aerodynamic behavior, controllable particle size structure, uniform and ordered pore channels and high porosity, so that good lung drug delivery efficiency can be realized.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of a cyclodextrin-metal organic framework in the preparation of inhalants and the inhalants. Background technique [0002] Metal-organic frameworks (MOFs) are a new type of porous material with a lattice structure, which is composed of metal ions or metal ion clusters and organic ligands connected by coordination bonds. Compared with traditional porous materials, metal-organic frameworks have the characteristics of large specific surface area, high porosity, diverse structures, strong adjustability, and easy functionalization. They have been widely used in the fields of catalysis, gas storage, separation, sensing, and drug delivery. application. Cyclodextrin-metal-organic frameworks (CD-MOFs) composed of potassium ions and γ-cyclodextrin have good biocompatibility and can increase the solubility and dissolution rate of poorly soluble drugs, and are considered to have grea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/40A61K9/72A61K9/14A61K45/00A61P11/00
CPCA61K9/0075A61K45/00A61K47/40A61K9/146A61P11/00
Inventor 陈航平李峰王亚龙赵志明周奕先聂金媛冯地桑
Owner GUANGZHOU NEWORLD PHARMA CO LTD
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