Novel preparation of medicinal antiviral drug inhalant and preparation method thereof

A technology for antiviral drugs and inhalants, which is applied in the field of formulations to achieve the effects of reducing the degree of flocculation, promoting dissolution and improving surface properties

Active Publication Date: 2021-10-12
NANJING ZHIHE MEDICINE TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The diversity, variability, and high transmissibility of viruses are great challenges to public health security

Method used

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  • Novel preparation of medicinal antiviral drug inhalant and preparation method thereof
  • Novel preparation of medicinal antiviral drug inhalant and preparation method thereof
  • Novel preparation of medicinal antiviral drug inhalant and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-6

[0063] Embodiment 1-6: Ribavirin dry powder inhaler prescription:

[0064] Table 1-1 Components and dosages of Examples 1-6, specifications: 10-300mg (1 suction)

[0065]

[0066]

[0067] Table 1-2 Components and dosages of comparative examples 1 to 6, specifications: 20-100mg (1 suction)

[0068]

[0069]

[0070] Table 1-3 Performance tests of Examples 1 to 6

[0071]

[0072] Table 1-4 Performance tests of comparative examples 1 to 6

[0073]

[0074]

[0075] Table 1-5 Components and dosages thereof of Examples 7-9 and Comparative Examples 7-8, (1 suction)

[0076]

[0077] Table 1-6 Performance tests of Examples 7-9 and Comparative Examples 7-8

[0078]

Embodiment 10～18

[0080] Table 2-1 Components and dosages of Examples 10-15, specifications: 10-300mg (1 suction)

[0081]

[0082]

[0083] Table 2-2 Performance tests of Examples 10-15

[0084]

[0085] Table 2-3 Components and dosages of Examples 16-18, (1 suction)

[0086]

[0087]

[0088] Table 2-4 Performance tests of Examples 16-18

[0089]

Embodiment 19～21

[0091] Table 3-1 Components and dosages of Examples 19-21, (1 suction)

[0092]

[0093]

[0094] Table 3-2 Performance tests for implementing 19-21

[0095]

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PUM

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Abstract

The invention discloses a novel preparation of a medicinal antiviral drug inhalant and a preparation method thereof. The novel preparation comprises a therapeutic agent, a coating agent, a suspending agent, a binding agent, a carrier and a cosolvent. The preparation disclosed by the invention not only has the effects of improving the surface performance of secondary particles and optimizing aerodynamics, but also can promote the dissolution and absorption of insoluble drugs and accelerate the effect after achieving the effect of improving the effective deposition rate in pulmonary alveoli.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to a novel preparation and preparation method of a pharmaceutical antiviral drug inhalation agent. Background technique [0002] The diversity, variability, and high transmissibility of viruses pose great challenges to public health security. After viral infection, high fever, general pain, and obvious fatigue often occur suddenly, and severe cases can even lead to pneumonia and respiratory failure. Influenza is a respiratory infectious disease caused by influenza virus, which is one of the major public health problems faced by human beings. The epidemiological characteristics of influenza are sudden outbreak, rapid spread, and widespread spread. Influenza has a high incidence rate and is generally susceptible. Influenza has severe clinical symptoms and a high incidence of complications, especially pneumonia, which can cause death. Anti-influenza virus treatment is one of the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/72A61K47/24A61K47/10A61K47/69A61K47/26A61K47/44A61K47/22A61K47/02A61K9/14A61K9/48A61K45/00A61K31/7056A61K31/404A61K31/4706A61K31/675A61K31/215A61K31/513A61K31/7105A61K38/21A61K31/427A61P31/12A61P31/14A61P11/00
CPCA61K9/0075A61K9/145A61K9/146A61K9/143A61K9/4858A61K9/4866A61K9/485A61K47/6951A61K45/00A61K31/7056A61K31/404A61K31/4706A61K31/675A61K31/215A61K31/513A61K31/7105A61K38/212A61K31/427A61P31/12A61P31/14A61P11/00
Inventor 张哲峰侯雯赵海峰
Owner NANJING ZHIHE MEDICINE TECH CO LTD
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