Thermo-sensitive polylactic acid high-molecular material and preparation method and application thereof

A technology of polymer material and temperature-sensitive polymer, which is applied in the field of temperature-sensitive polylactic acid polymer material and its preparation, can solve the problems of high cost, difficult application, complicated preparation process of temperature-sensitive polymer, etc.

Active Publication Date: 2021-05-07
SOUTH CHINA NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] It is worth noting that the modification of polylactic acid based on temperature-sensitive polymers is either too expensive or the preparation process of temperature-sensitive polymers is complicated, and most of them cannot meet the requirements of low cost, simple process and adjustable material properties at the same time. and other conditions, it is difficult to have further application [Cho H, Gao J, Kwon G S.J Control Release,2016,240:191]

Method used

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  • Thermo-sensitive polylactic acid high-molecular material and preparation method and application thereof
  • Thermo-sensitive polylactic acid high-molecular material and preparation method and application thereof
  • Thermo-sensitive polylactic acid high-molecular material and preparation method and application thereof

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preparation example Construction

[0045] The invention provides a temperature-sensitive polylactic acid polymer material, the preparation method of which is as follows:

[0046] Firstly, the prepolymer is prepared by a one-time feeding method, a magnetic stirrer is placed in a fully dry reaction flask, lactic acid monomer and maleic anhydride are added to the reaction flask, and the electromagnetic stirring is turned on. Dehydration at normal pressure first, and then vacuum prepolymerization to obtain prepolymer.

[0047] Then, a catalyst is added to the prepolymer to catalyze direct melt polymerization. Next, remove the vacuum, add temperature-sensitive polymer monomers and initiators into the above reaction system, and start electromagnetic stirring to carry out the reaction.

[0048] Finally, purify the product, first dissolve the product with a solvent, heat the product if necessary, and then use deionized water to precipitate and wash it. After filtering, the filter residue is heated and dried in a vacuu...

Embodiment 1

[0054] Copolymer PLAMN 4 Synthesis:

Embodiment 2

[0057] Copolymer PLAMN 7 Synthesis:

[0058] Put a magnetic stirring bar into the reaction flask, add about 3.6g (40mmol) of lactic acid monomer and 0.2g (2mmol) of maleic anhydride into the reaction flask, and start stirring. Under normal pressure, dehydrate at 130°C for 6 hours, then vacuumize with a circulating water vacuum pump, and prepolymerize for 8 hours. After the prepolymerization, add 0.01g catalyst SnO, vacuumize with a rotary vane vacuum oil pump, and polymerize at 140°C for 3h. Release the vacuum, add 1.6g (14mmol) of N-isopropylacrylamide and 0.02g of potassium persulfate, and polymerize at 100°C for 4h. After the polymerization, the product was dissolved with methanol, and then precipitated and washed with deionized water. After filtration, the filter residue was dried in a vacuum oven at 45°C for 24 hours to obtain the copolymer PLAMN 7 , the yield was 49%.

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Abstract

The invention discloses a thermo-sensitive polylactic acid high-molecular material and a preparation method and application thereof, the structural formula of the thermo-sensitive polylactic acid high-molecular material is shown in the specification, R is a polymerization chain segment of a thermo-sensitive polymer monomer, n is an integer between 10 and 100, q is an integer between 10 and 10, and m is an integer between 10 and 100. The novel polylactic acid high-molecular material is obtained by carrying out copolymerization reaction on cheap and easily available bio-based lactic acid monomers, simple maleic anhydride and temperature-sensitive polymer monomers through direct melt polycondensation by a one-pot method, and the polylactic acid high-molecular material has temperature sensitivity and biodegradability. The material is expected to be used as a carrier of small molecular drugs or antibacterial drugs, or can be directly used as a wound dressing base material in a form of powder, which is blended with a solvent into a gel form or spun into a fibrous form.

Description

technical field [0001] The invention relates to the technical field of polymer materials, in particular to a temperature-sensitive polylactic acid polymer material and its preparation method and application. Background technique [0002] Polylactic acid polymer materials are widely used in biomedical research because of their good biocompatibility, biodegradability, and adjustability. Deliver or trigger drug release. [0003] The methods for preparing temperature-sensitive polylactic acid macromolecular materials reported in the literature include the following: [0004] (1) Using polyamide polymers such as poly-N-isopropylacrylamide (PNIPAM) and poly-N-vinylcaprolactam (PNVCL) as raw materials to modify polylactic acid materials to prepare functionalized temperature-sensitive polylactic acid materials [Alexander A, Khan J, Saraf S, et al. Eur J Pharm Biopharm, 2014, 88(3): 575; Zhao H L, Tao L, Yu R, et al. JNanosci Nanotechnol, 2015, 15(8): 5553 ; Seidi F, Heshmati P. C...

Claims

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Application Information

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IPC IPC(8): C08F283/01C08F220/54
CPCC08F283/01C08F220/54
Inventor 罗时荷汪朝阳肖颖
Owner SOUTH CHINA NORMAL UNIVERSITY
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