Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Cefquinome sulfate injection and preparation method thereof

A cefquinome sulfate and injection technology, applied in the field of biomedicine, can solve the problem of low antibacterial activity and achieve the effect of enhancing the antibacterial spectrum

Inactive Publication Date: 2021-04-23
SICHUAN CHENGKANG ANIMAL PHARMA
View PDF4 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Cefquinome sulfate injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032]Sulfite ceaquinoxime injection, comprising the following mass percent components: surfactant lecy phospholipids 0.5%, suspended stearate 2%, drug ingredient 2.5%;

[0033]In this embodiment, the pharmaceutical ingredients are: 70% of sulfate cequin quin quin quinoxime, 30% of golden hormone;

[0034]In this embodiment, the preparation method of sulfite cequin quinoxime injection includes the following steps:

[0035](1) Sterile filtration of oleate ethyl olerate by 0.25 um microporous filter film;

[0036](2) After weighing the surface active agent, aluminum aluminum aluminum and the pharmaceutical ingredients are sufficiently mixed according to the percentage of mass, and the temperature is maintained at 10 ° C, and the high shear machine is started to obtain a superfine stable suspension;

[0037](3) The ultrafine stabilization suspension obtained by step (2) is placed in colloid mill, which is sufficiently ground to nano-solution, sterilizing, and dispensing.

Embodiment 2

[0039]Sulfite ceaquinoxime injection, comprising the following mass percent components: surfactant lecy phospholipids 0.5%, suspended stearate 2%, drug ingredient 2.5%;

[0040]In this embodiment, the pharmaceutical ingredients are: 90% of sulfate cequin quinoxime, 10% of golden hormone;

[0041]In this embodiment, the preparation method of sulfite cequin quinoxime injection includes the following steps:

[0042](1) Sterile filtration of oleate ethyl olerate by 0.25 um microporous filter film;

[0043](2) After weighing the surface active agent, aluminum aluminum aluminum and the pharmaceutical ingredients are sufficiently mixed according to the percentage of mass, and the temperature is maintained at 10 ° C, and the high shear machine is started to obtain a superfine stable suspension;

[0044](3) The ultrafine stabilization suspension obtained by step (2) is placed in colloid mill, which is sufficiently ground to nano-solution, sterilizing, and dispensing.

Embodiment 3

[0046]Sulfite ceaquinoxime injection, comprising the following mass percent components: surfactant lecy phospholipids 0.5%, suspended stearate 2%, drug ingredient 2.5%;

[0047]In this embodiment, the pharmaceutical component is: 80% of sulfate cequin quin quin quinol, 20% of golden hormone;

[0048]In this embodiment, the preparation method of sulfite cequin quinoxime injection includes the following steps:

[0049](1) Sterile filtration of oleate ethyl olerate by 0.25 um microporous filter film;

[0050](2) After weighing the surface active agent, aluminum aluminum aluminum and the pharmaceutical ingredients are sufficiently mixed according to the percentage of mass, and the temperature is maintained at 10 ° C, and the high shear machine is started to obtain a superfine stable suspension;

[0051](3) The ultrafine stabilization suspension obtained by step (2) is placed in colloid mill, which is sufficiently ground to nano-solution, sterilizing, and dispensing.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a cefquinome sulfate injection and a preparation method thereof, and belongs to the field of biological medicines. The injection comprises a carrier, a surfactant, a suspending agent and medicinal components, wherein the medicinal components include the following components in percentage by mass of 60-90% of cefquinome sulfate and 1-40% of a synergist; and the synergist is any one or a composition of more of hypericin, sulbactam, trimethoprim and potassium clavulanate in any proportion. According to the invention, the cefquinome sulfate is used as a main bactericidal and antiviral drug, and the hypericin, the sulbactam, the trimethoprim and the potassium clavulanate are used as the synergist, so that the antibacterial spectrum of the whole injection can be enhanced, the medicine effect can be enhanced, and the cure rate can be increased. Low-temperature high shearing is adopted, so that the viscosity of the injection is reduced, and the stability is enhanced.

Description

Technical field[0001]The present invention relates to the field of biopharmaceutical, and more particularly to a sulfite cequin quinum injection and a preparation method thereof.Background technique[0002]Sulfite cequin quinoxime is the fourth-generation animal dedicated cefosporin antibiotics, with a broader antibacterial spectrum, stronger antibacterial activity, high stability of β-lactamase, longer plasma half-life, no kidney toxicity, etc. Many advantages, in the clinical application of veterinarians, more and more applications. Sulfate cequin quin quinoxime injection can quickly penetrate the outer membrane of Lelachin negative bacteria, which is stable to the I-type β-lactamase located around the cytoplate and low affinity, and the penicillin binding protein (PBP) affinity, antibacterial The activity is strong, the clinical amount is small, the effect is fast, the effect is rapid, and it can play a role in 1 hour after use, and there is no drug residue and anti-drug resistance...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/546A61K9/10A61K47/24A61J3/00A61P31/04A61K31/122A61K31/424A61K31/43A61K31/505
CPCA61J3/00A61K9/0019A61K9/10A61K31/122A61K31/424A61K31/43A61K31/505A61K31/546A61K47/24A61P31/04A61K2300/00
Inventor 胡进成杨军王芝丽
Owner SICHUAN CHENGKANG ANIMAL PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com