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Composite bacterial cellulose dressing based on controllable nanofiber space structure and preparation method

A technology of fiber space structure and bacterial cellulose, which can be used in bacteria, bandages, drug delivery and other directions, and can solve the problems of high water vapor transmission rate and fast water loss rate.

Active Publication Date: 2021-04-02
FUJIAN CHANGLE CITY CHANGYUAN TEXTILE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But there are also some problems with BC skin repair materials: the current X and X PHMB products require a secondary dressing when in use
Although it has been reported that the nano-network structure on the surface of BC can prevent bacterial invasion, but its water vapor transmission rate is relatively high, and the water loss rate is relatively fast when there is no secondary dressing.

Method used

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  • Composite bacterial cellulose dressing based on controllable nanofiber space structure and preparation method
  • Composite bacterial cellulose dressing based on controllable nanofiber space structure and preparation method

Examples

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Embodiment 1

[0049] A method for preparing a composite bacterial cellulose dressing based on a controllable nanofiber spatial structure, the steps are as follows:

[0050] (1) Dissolve gelatin particles (content: 1wt%) and bovine serum albumin (content: 0.2wt%) in deionized water, stir at 35°C for 1h, add citric acid to adjust the pH value to 5, and obtain gelatin-based aqueous solution;

[0051] (2) Add the gelatin-based aqueous solution dropwise to the non-woven material containing the protein component, and dry naturally to obtain a composite non-woven material with a gelatin-based component content of 0.1 wt%. The natural drying is to dry at room temperature for 12 hours; The grammage of the non-woven material of the protein component is 40g / m 2 , is obtained by spunlace non-woven processing of medical staple fibers with an average diameter of 5 μm containing protein components (content is 0.1wt%); medical staple fibers containing protein components are obtained by adding silk protein...

Embodiment 2

[0071] A method for preparing a composite bacterial cellulose dressing based on a controllable nanofiber spatial structure, the steps are as follows:

[0072] (1) Dissolve gelatin particles (content: 1.3wt%) and bovine serum albumin (content: 0.4wt%) in deionized water, stir at 37°C for 2 hours, add citric acid to adjust the pH value to 5, A gelatin-based aqueous solution is obtained;

[0073] (2) Add the gelatin-based aqueous solution dropwise to the nonwoven material containing the protein component, and dry naturally to obtain a composite nonwoven material with a gelatin-based component content of 0.5 wt%. The natural drying is at room temperature for 48 hours; The grammage of the non-woven material of the protein component is 70g / m 2 , is obtained by spunlace non-woven processing of medical short fibers with an average diameter of 10 μm containing protein components (content is 3wt%); medical short fibers containing protein components are obtained by adding keratin soluti...

Embodiment 3

[0093] A method for preparing a composite bacterial cellulose dressing based on a controllable nanofiber spatial structure, the steps are as follows:

[0094] (1) Dissolve gelatin particles (content: 1.5wt%) and bovine serum albumin (content: 0.6wt%) in deionized water, stir at 40°C for 3 hours, add acetic acid to adjust the pH value to 5, and obtain gelatin-based aqueous solution;

[0095] (2) Add the gelatin-based aqueous solution dropwise to the nonwoven material containing the protein component, and dry it in an oven to obtain a composite nonwoven material with a gelatin-based component content of 1 wt%. The oven drying temperature is 35° C. and the time is 1 h ;The grammage of non-woven materials containing protein components is 100g / m 2 , is obtained by spunlace non-woven processing of medical short fibers with an average diameter of 20 μm containing protein components (content is 5wt%); the medical short fibers containing protein components are obtained by adding reduc...

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Abstract

The invention relates to a composite bacterial cellulose dressing based on a controllable nanofiber space structure and a preparation method thereof. The preparation method comprises the steps of: firstly, dropwise adding gelatin-based aqueous solution into a non-woven material containing a protein component; after drying, dropwise adding culture bacterium solution onto the non-woven material; until the composite non-woven material adsorbs the culture bacterium solution to be saturated, adding fermentation culture solution to carry out standing culture; and finally, immersing a compound obtained by standing culture into triton aqueous solution with the concentration of 0.1 to 1wt% for purification, and drying to obtain the non-woven material composite bacterial cellulose dressing. The prepared dressing has a density structure, specifically, bacterial cellulose nanofibers are distributed on non-woven micron-sized fibers, and the distribution and the density degree of the nanofibers areadjustable. The prepared non-woven material composite bacterial cellulose dressing prepared by the invention has good biocompatibility, mechanical properties and wound exudate absorption performance,and has huge application prospects in the biomedical fields of a wound dressing, a human body repair material, a tissue engineering material and the like.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and relates to a composite bacterial cellulose dressing based on a controllable nanofiber spatial structure and a preparation method thereof, in particular to a composite bacterial cellulose dressing based on a controllable nanofiber spatial structure and a preparation method thereof . Background technique [0002] Human skin is the largest organ of the human body and is the natural barrier of the human body. It plays an important role in maintaining the stability of the internal environment and preventing the invasion of microorganisms. People will inevitably cause many types of wounds in production and life. Covering exposed wounds with dressings is a commonly used clinical wound treatment method. A wound dressing with excellent performance can play part of the function of the skin, provide a moist environment conducive to wound healing, and even protect and prevent bacterial inva...

Claims

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Application Information

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IPC IPC(8): A61L15/32A61L15/28A61L15/42C12N1/20C12P19/04
CPCA61L15/32A61L15/28A61L15/42C12P19/04C12N1/20A61L2400/12C08L89/00C08L1/02
Inventor 李喆孙卫华王姣生俊露姚勇波尹岸林于利超李海东吕向国
Owner FUJIAN CHANGLE CITY CHANGYUAN TEXTILE
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