Polymer medical instrument with hydrophilic lubricating coating and preparation method thereof

A technology of hydrophilic polymers and medical devices, applied in the field of medical devices, can solve the problem of not being able to guarantee long-term and stable lubrication performance, not being able to meet large-volume, fast production processes, and affecting the overall biocompatibility of devices and other problems, to achieve the effect of long-term and stable hydrophilic lubrication performance, uniform and controllable coating thickness, and good biocompatibility

Pending Publication Date: 2021-03-30
苏州凝智新材料发展有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

CN 110819183 A selects water-soluble monomer as the coating precursor material, uses silane coupling agent as the functional group for bonding, and realizes firm hydrophilic coating on the surface of medical equipment through the method of initiating polymerization-dipping coating-heating and curing layer, but the coating material may contain unreacted monomeric raw materials, affecting the biocompatibility of the overall device, and the entire coating process takes a long time, which is not conducive to mass production
[0005] Generally speaking, the current hydrophilic coating materials and preparation methods cannot guarantee long-term and stable lubricating performance, and there are also certain defects in the production process, which cannot meet the large-scale and rapid production process, and the required The cost is high, therefore, a new hydrophilic lubricating coating needs to be provided to meet the application requirements

Method used

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  • Polymer medical instrument with hydrophilic lubricating coating and preparation method thereof
  • Polymer medical instrument with hydrophilic lubricating coating and preparation method thereof
  • Polymer medical instrument with hydrophilic lubricating coating and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] A kind of Pebax (polyether block polyamide) guide wire with hydrophilic lubricating coating, its preparation method is as follows:

[0060] (1) Polyvinylpyrrolidone (model Sigma-Aldrich#PVP360, molecular weight is about 360000) with a mass fraction of 13% and benzophenone with a mass fraction of 0.5% are uniformly dissolved in water and ethanol (volume ratio is 1:1 ) in the mixed solution to obtain the precursor solution of the hydrophilic lubricating coating;

[0061] (2) Clean the surface of the Pebax guide wire with isopropanol, ethanol and water in sequence, and let it dry for 3 minutes;

[0062] (3) Oxygen plasma treatment was performed on the Pebax guide wire for 1 min, and then further soaked in an acetone solution with a mass fraction of 10% benzophenone for 5 min to activate its surface;

[0063] (4) The precursor solution obtained in step (1) is coated on the surface of the Pebax guide wire after step (3) by the dipping method, and the pulling speed in the di...

Embodiment 2

[0066] This embodiment provides a TPU guide wire with a hydrophilic lubricating coating, and its preparation method is as follows:

[0067] (1) The polyethylene glycol (model is Supelco 81206, molecular weight is about 218000) that the mass fraction is 10% and the benzophenone that the mass fraction is 0.2% are dissolved in water and ethanol (volume ratio is 1.2:1) In the mixed solution, the precursor solution of hydrophilic lubricating coating is obtained;

[0068] (2) Wash the surface of the TPU guide wire with isopropanol and water in turn, and dry it for 5 minutes;

[0069] (3) Carry out oxygen plasma treatment 2min to TPU guide wire, further soak 2min in the ethanol solution that is 5% benzophenone by mass fraction again, make its surface activation;

[0070] (4) Coat the precursor liquid obtained in step (1) on the surface of the TPU guide wire after the treatment in step (3), and the coating of the coating is realized by dipping, and the pulling speed is 60mm / min;

[...

Embodiment 3

[0073] The present embodiment provides a Pebax guide wire with a hydrophilic lubricating coating, and its preparation method is as follows:

[0074] (1) Agarose (model is Sigma-Aldrich#A1296) with a mass fraction of 5% and coumarone with a mass fraction of 2% are uniformly dissolved in a mixed solution of water and ethanol (volume ratio of 1.2:1), Obtain the precursor solution of hydrophilic lubricating coating;

[0075] (2) Clean the surface of the Pebax guide wire with isopropanol and water in turn, and let it dry for 1 min;

[0076] (3) Oxygen plasma treatment was carried out to the Pebax guide wire for 5 min, and then further soaked in an ethanol solution of 8% coumarone by mass fraction for 1 min to activate its surface;

[0077] (4) Coat the precursor solution obtained in step (1) on the surface of the Pebax guide wire after the treatment in step (3), the coating is achieved by dipping, and the pulling speed is 40mm / min;

[0078] (5) UV-cure the coated Pebax guide wire...

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Abstract

The invention provides a polymer medical instrument with a hydrophilic lubricating coating and a preparation method thereof, and the preparation method comprises the following steps: (1) mixing a hydrophilic polymer material, an initiator and a solvent to obtain a precursor solution of the hydrophilic lubricating coating; (2) carrying out oxygen plasma treatment on the polymer medical instrument,and then soaking the polymer medical instrument in a pretreatment solution, wherein the pretreatment liquid contains a photoinitiator; and (3) coating the surface of the polymer medical instrument treated in the step (2) with the precursor solution obtained in the step (1), and then carrying out photocuring to obtain the polymer medical instrument with the hydrophilic lubricating coating. The polymer medical instrument with the hydrophilic lubricating coating has the stable and long-acting super-lubricating and hydrophilic characteristics, the monomer polymerization process does not exist in the preparation method of the polymer medical instrument, and it can be guaranteed that the hydrophilic lubricating coating has excellent biocompatibility.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and relates to a polymer medical device with a hydrophilic lubricating coating and a preparation method thereof. Background technique [0002] The surface of medical devices coated with medical lubricating coatings has a low surface friction coefficient, such as guide wires, PTCA catheters, catheters, endoscopes, etc., which can reduce the friction between the device and human tissue when it is inserted and pulled out , reduce the pain of the patient during the operation, can effectively reduce the difficulty of the doctor's operation, and at the same time can avoid the disadvantage of being unable to enter the lesion due to the large frictional resistance of harsh lesions. [0003] At present, the surface coefficient of friction of implantable or interventional medical devices in blood and tissue environments can be reduced by coating hydrophilic coatings, but the existing problems of th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/056C08J7/12A61L31/10A61L31/14C08L77/00C08L75/04C09D139/06C09D171/02C09D105/12
CPCC08J7/056C08J7/0427C08J7/123A61L31/10A61L31/14C08J2377/00C08J2375/04C08J2439/06C08J2471/02C08J2405/12A61L2300/452
Inventor 程思博念国栋夏崟
Owner 苏州凝智新材料发展有限公司
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