Antibacterial hemostatic healing-promoting gel, preparation method and application thereof

Abstract

The invention provides antibacterial hemostatic healing-promoting gel, a preparation method and an application thereof. The gel is prepared from the following raw materials: 4-18 parts of carboxylic acid or sodium carboxylate with active double bonds, 2-10 parts of amide with active double bonds, 1-3 parts of aldehyde with active double bonds, 30-100 parts of fish collagen peptide and 2-3 parts ofheparin sodium; and 1-5 parts of modified guanidine salt with active double bonds, 3-10 parts of chitosan, 1-5 parts of modified diamine with active double bonds, 0.4-0.8 part of a double bond cross-linking agent, 4-7 parts of L-arginine, 50-200 parts of aloe raw gel, 5-10 parts of sodium beta-glycerophosphate and 200-600 parts of deionized water. The antibacterial hemostatic healing-promoting gel has multiple wound healing effects, promotes skin capillary generation, facilitates tissue growth, protects wound nerves, achieves a hemostatic effect by quickly plugging damaged blood vessels, hasexcellent antibacterial property, and forms a protective isolation layer at a wound part to facilitate antibacterial hemostasis and healing promotion of a wound.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to an antibacterial hemostatic and healing-promoting gel, a preparation method and an application thereof. Background technique [0002] In daily work and life, people will inevitably cause injuries and bleeding wounds. The body's physiological hemostasis alone is far from achieving rapid and effective hemostasis. Therefore, it is necessary to introduce exogenous substances to accelerate wound hemostasis. Hemostatic materials have always been a research hotspot in the field of biomedicine. Traditional hemostatic materials tend to adhere to the wound surface, and when removed, it is likely to damage the newly recovered wound surface again. The current frontier hotspot is absorbable hemostatic materials. At present, the main domestic and foreign Absorbable hemostatic materials include fibrin glue, gelatin, collagen, oxidized cellulose, chitosan, and calcium alginate. Due to poor r...

AI Technical Summary

Problems solved by technology

However, there are still the following problems: the current hemostatic materials have single effects, narrow application areas, do not have good elasticity and air permeability, are easy to cause adverse reactions such as inflammation, and have slow hemostatic speed, resulting in poor hemostatic effect; and It is easy to adhere to the wound surface, and it is likely to damage the newly recovered wound surface again when it is removed

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