Coenzyme Q10, VD3 and VK2 sugar vitrified microcapsules and preparation method thereof

A sugar vitrification and microencapsulation technology, applied in the field of vitamins, can solve the problems of poor aqueous solution and stability, low yield of microcapsules, easy to agglomerate in rehydration, etc., and achieves improved uniformity, high microencapsulation efficiency, and good water solubility. Effect

Pending Publication Date: 2021-03-19
XIAMEN KINGDOMWAY BIOTECH CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the defects that the coenzyme Q10, VD3 and VK2 microcapsules obtained by the spray drying method are prone to cavities, cracks and depressions, and the rehydration is easy to cluster, the aqueous solution and the stability are poor, and overcome the adoption of sugar vitrification technology. The yield of the obtained coenzyme Q10, VD3 and VK2 microcapsules is low, and it provides a method that can prevent the formation of cavities inside the microcapsules and the appearance of cracks and depressions on the surface, and can efficiently produce a microcapsule with excellent water solubility, stability and recombination. Milky coenzyme Q10, VD3 and VK2 microcapsules and preparation method thereof

Method used

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  • Coenzyme Q10, VD3 and VK2 sugar vitrified microcapsules and preparation method thereof
  • Coenzyme Q10, VD3 and VK2 sugar vitrified microcapsules and preparation method thereof
  • Coenzyme Q10, VD3 and VK2 sugar vitrified microcapsules and preparation method thereof

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preparation example Construction

[0038] The preparation method of the sugar vitrified microcapsules provided by the invention comprises the following steps:

[0039] (1) The core material and the wall material are mixed to form an emulsion, the core material contains coenzyme Q10, VD3 and VK2, and the wall material contains starch sodium octenyl succinate, carbohydrate compound, pH value regulator and enhancer Plasticizer, the viscosity of the starch sodium octenyl succinate at 25°C is 20-100mPa·s, and the DE value of the carbohydrate compound is >16;

[0040] (2) Pass supercritical CO into the emulsion 2 fluid, at a temperature and pressure sufficient to make supercritical CO 2 The fluid is maintained under supercritical conditions for a period of time so that the supercritical CO 2 The fluid dissolves in the wall material causing the wall material to swell, followed by rapid pressure release allowing the wall material to solidify around the core material, resulting in sugar vitrified microcapsules.

[00...

Embodiment 1

[0048] (1) Melt 55g of coenzyme Q10 crystals, 0.04g of VD3 crystals, 2.0g of VK2 oil, 5g of glyceryl monostearate, 87.76g of MCT oil, and 0.2g of rosemary extract in an oil-dissolving pot at 40°C to obtain coenzyme Q10 , VD3, VK2 oil phase liquid. Mix 200g sodium starch octenyl succinate (the viscosity at 25°C is 72mPa·s, the same below), 300g maltodextrin (Roquette, DE18-20, the same below), 300g solid corn syrup powder (Bowling Bio , DE30-50, the same below), 5g sodium citrate, 5g sodium ascorbate, 40g glycerin were dissolved in 600g water, heated to 40°C and kept warm to obtain an aqueous phase solution. Add the above coenzyme Q10, VD3, VK2 oil phase solution into the water phase solution, shear at 10000rpm for 20min, and get the oil droplet size D 50 Coenzyme Q10, VD3, VK2 emulsion of 0.762μm and viscosity of 180mPa·s.

[0049] (2) Add the above coenzyme Q10, VD3, VK2 emulsion into supercritical CO 2 In the fluid granulation equipment, supercritical CO 2 Fluid, the tem...

Embodiment 2

[0052] (1) Melt 105g of coenzyme Q10 crystals, 0.07g of VD3 crystals, 4.0g of VK2 oil, 5g of monoglyceride citrate, 30.43g of MCT oil, and 0.5g of rosemary extract in an oil-dissolving pot at 50°C to obtain coenzyme Q10, VD3, VK2 oil phase liquid. Dissolve 205g sodium starch octenyl succinate, 300g maltodextrin, 270g solid corn syrup powder, 10g sodium citrate, 10g sodium ascorbate, and 60g glycerin in 600g water, heat to 50°C and keep it warm to obtain an aqueous phase solution. Add the above coenzyme Q10, VD3, VK2 oil phase solution into the water phase solution, shear at 10000rpm for 20min, and get the oil droplet size D 50 Coenzyme Q10, VD3, VK2 emulsion of 0.815μm and viscosity of 190mPa·s.

[0053] (2) Add the above coenzyme Q10, VD3, VK2 emulsion into supercritical CO 2 In the fluid granulation equipment, supercritical CO 2 Fluid, the temperature is controlled at 30°C and the pressure is controlled at 40MPa for 20min, so that the supercritical CO 2 The fluid dissolv...

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Abstract

The invention belongs to the technical field of vitamins, and relates to a coenzyme Q10, VD3 and VK2 sugar vitrified microcapsule and a preparation method thereof. The sugar vitrified microcapsule comprises a core material and a wall material, the core material contains coenzyme Q10, VD3 and VK2, the wall material contains starch sodium octenylsuccinate, a saccharide compound, a pH value regulatorand a plasticizer, the viscosity of the starch sodium octenylsuccinate at 25 DEG C is 20-100mPa. s, and the DE value of the saccharide compound is larger than 16. According to the method provided bythe invention, cavities can be prevented from being formed in the microcapsules, cracks and recesses can be prevented from appearing on the surfaces of the microcapsules, and coenzyme Q10, VD3 and VK2microcapsules with excellent water solubility, stability and multiple emulsion properties can be efficiently produced.

Description

technical field [0001] The invention belongs to the technical field of vitamins, and in particular relates to a vitrified microcapsule of coenzyme Q10, VD3 and VK2 sugar and a preparation method thereof. Background technique [0002] Coenzyme Q10, also known as ubiquinone, is a yellow or light yellow crystalline powder. Coenzyme Q10 is unstable in light, acidic, alkaline, high temperature, and oxidizing environments. Vitamin D3 (referred to as VD3) is white columnar crystal or crystalline powder, odorless and tasteless, good heat resistance, but unstable to light, easy to oxidize in the air. Vitamin K2 (referred to as VK2) is a natural vitamin containing the basic structure of menaquinone and has anti-hemorrhagic effects. It is yellow crystal or oily liquid at room temperature, heat-resistant, but easily destroyed by light and oxygen. At present, coenzyme Q10, VD3 and VK2 are usually made into microcapsules, because microcapsules can effectively embed the active ingredient...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/15A23L33/155A23L33/00A23P10/30B01J13/02
CPCA23L33/15A23L33/155A23L33/00A23P10/30B01J13/02A23V2002/00A23V2200/30A23V2250/7106A23V2250/7144A23V2200/06A23V2250/616A23V2250/61A23V2250/5114A23V2250/28A23V2250/628A23V2250/638A23V2250/606A23V2250/612A23V2250/032A23V2250/2134A23V2250/6416A23V2250/642A23V2250/21A23V2250/712A23V2250/194
Inventor 刘锦洪林木荣王文积
Owner XIAMEN KINGDOMWAY BIOTECH CO LTD
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