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Biovalve crosslinking method for improving mechanical and anticoagulation properties

A technology of biological valve and cross-linking method, which is applied in the field of biomedical materials, can solve the problems of high cost and low utilization rate of raw materials, and achieve the effect of improving tensile strength at break, enhancing biocompatibility and service life

Active Publication Date: 2021-03-12
JILIN VENUS HAOYUE MEDICAL LTD
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  • Claims
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Problems solved by technology

[0006] On the other hand, glutaraldehyde crosslinking is a key step in the preparation process of existing bioprosthetic valves on the market. However, the mechanical strength of the existing glutaraldehyde crosslinked pericardium still needs to be further improved, especially compared with long-term service For leaflet materials, it is necessary to use thicker pericardium raw materials to meet the mechanical performance requirements, and the utilization rate of raw materials is low, resulting in high costs

Method used

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  • Biovalve crosslinking method for improving mechanical and anticoagulation properties
  • Biovalve crosslinking method for improving mechanical and anticoagulation properties
  • Biovalve crosslinking method for improving mechanical and anticoagulation properties

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Embodiment 1

[0042] In this embodiment, the freshly collected porcine pericardium was washed with deionized water for 2 hours at 4°C and 100 RPM under shaking conditions. Then the porcine pericardium was immersed in 25% ethanol solution (volume ratio) with a mass fraction of 3,4-dihydroxybenzaldehyde of 5% at 37°C for 24 hours. Afterwards, it was washed with 75% ethanol (volume ratio). Then use 20mM ammonium persulfate to soak for 24 hours at 37°C. Finally, 75% ethanol (volume ratio) and deionized water were used for cleaning.

experiment example

[0044] Schematic diagram of the chemical principle of 3,4-dihydroxybenzaldehyde modified pericardium and ammonium persulfate oxidative cross-linking. figure 1 shown. During the treatment, the glutaraldehyde cross-linking treatment group was set as the control group, that is, the pig pericardium was soaked in 0.625% glutaraldehyde for 24 hours.

[0045] The Cauchy stress-rupture tensile strength analysis results of the embodiment and the glutaraldehyde cross-linking treatment control group are shown in Table 1, and the quantitative analysis results of platelet adhesion on the material surface are shown in Table 2. The blood contact test material surface of the rabbit half body The scanning electron microscope results are as Figure 4 shown.

[0046] Table 1

[0047] Tensile strength at break / MPa Glutaraldehyde control group 24.20±2.143 Example 19.97±0.58

[0048] Table 2

[0049] relative platelet adhesion Glutaraldehyde control...

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Abstract

The invention discloses a biovalve crosslinking method for improving mechanical and anticoagulation properties, which belongs to the technical field of biomedical materials. According to the invention, 3, 4-dihydroxybenzaldehyde is adopted to modify a biological material, a diphenol group is introduced to the biological material, and then the diphenol group is polymerized and cross-linked with each other, so that the cross-linking immobilization of the biovalve is realized. Compared with traditional glutaraldehyde crosslinking, the method provided by the invention has the advantages that the breaking tensile strength, platelet adhesion resistance and anticoagulation performance of the biological material can be improved, the biocompatibility of the biological material is potentially enhanced, and the service life of the biological material is prolonged.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a biological valve cross-linking method for improving mechanical and anticoagulant properties, and the obtained biological valve material and application thereof. [0002] technical background [0003] At present, artificial heart valves widely used in clinical practice include mechanical valves and biological valves. The hemocompatibility and hemodynamic properties of artificial bioprosthetic valves are superior to those of mechanical valves, and lifelong anticoagulant therapy is not required. However, bioprosthetic valves have the limitations of leaflet hardening, calcification and even rupture. The service life of biological valves is about 10-15 years. After the valve function fails, it must be replaced by a second operation through thoracotomy or intervention. For the interventional biological heart valve, the blood flow in the heart is fast, and the...

Claims

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Application Information

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IPC IPC(8): A61L27/36A61L27/50
CPCA61L27/3604A61L27/3687A61L27/50A61L2430/40
Inventor 王云兵郑城吴柄钢雷洋杨立
Owner JILIN VENUS HAOYUE MEDICAL LTD
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