Broad-spectrum HPV antibody and preparation method and application thereof

An antibody, broad-spectrum technology, applied in the direction of antibodies, chemical instruments and methods, antiviral agents, etc., can solve problems such as unrealistic, lack of capsid protein expression, vaccine and therapeutic drug failure, etc., to achieve rapid effect and drug delivery. Simple way to effect

Inactive Publication Date: 2021-02-26
HUAKE TONGJI STEM CELL GENETIC ENG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is not realistic to simply increase the types of vaccine target antigens to completely prevent different human papillomavirus infections in different places
In addition, for positive patients in the late stage of HPV infection, due to the integration of HPV viral DNA into the host cell DNA, the expression of capsid proteins L1 and L2 is lost; resulting in the failure of vaccines and therapeutic drugs targeting L1 and L2

Method used

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  • Broad-spectrum HPV antibody and preparation method and application thereof
  • Broad-spectrum HPV antibody and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1 proposes a broad-spectrum HPV antibody, and the particle size of the broad-spectrum HPV antibody is about 50 nm. The broad-spectrum HPV antibody is prepared by separating antigens comprising multiple human papillomavirus component fragments, wherein the multiple human papillomavirus component fragments are from the following components: HPV16 and HPV18; the antigen Selected from: HPV fusion gene eukaryotic expression protein antigen.

[0034] The administration method is to administer the drug by setting it on a condom, the administration frequency is once every 2 days, 30 days is a cycle, and 6 cycles of treatment are performed.

Embodiment 2

[0036] Example 2 proposes a broad-spectrum HPV antibody, and the particle size of the broad-spectrum HPV antibody is about 70nm. The broad-spectrum HPV antibody is prepared by separating antigens comprising multiple human papillomavirus component fragments, wherein the multiple human papillomavirus component fragments are from the following components: HPV 33, HPV 35, HPV 39. HPV16 and HPV18; said antigen is selected from: HPV protein common antigen synthetic epitope polypeptide antigen.

[0037] The administration method is to administer the drug by setting it on a condom, the administration frequency is once every 3 days, 30 days is a cycle, and 6 cycles of treatment are performed.

Embodiment 3

[0039] Example 3 proposes a broad-spectrum HPV antibody, and the particle size of the broad-spectrum HPV antibody is about 20nm. The broad-spectrum HPV antibody is prepared by separating antigens comprising multiple human papillomavirus component fragments, wherein the various human papillomavirus component fragments are from the following components: HPV 16, HPV 18, HPV 39. HPV 45, HPV 51, HPV 52, HPV 56, HPV 58, HPV 59 and HPV 68; said antigen is selected from: fusion protein virus-like particle antigens.

[0040] The administration method is to administer the drug by setting it on a condom, the administration frequency is once every 2 days, 30 days is a cycle, and 6 cycles of treatment are performed.

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Abstract

The invention provides a broad-spectrum HPV antibody. The particle size of the broad-spectrum HPV antibody is 1-100nm; preferably, the particle size of the broad-spectrum HPV antibody is 10-50nm. Thebroad-spectrum HPV antibody has a very small particle size of about 1-100nm, can be applied by being arranged on a contraceptive device or equipment and has the advantages of being simple in administration mode, quick in effect and the like. In addition, the broad-spectrum HPV antibody is effective for most HPV and can be widely used for preventing and treating most types of HPV.

Description

technical field [0001] The invention relates to a broad-spectrum HPV antibody and its preparation method and application. Background technique [0002] Human papillomavirus (humanpapillomavirus, HPV) belongs to papillomavacuolating virus of Papovaviridae, is a spherical DNA virus, can cause squamous epithelial proliferation of human skin and mucous membrane, and is currently a confirmed carcinogenic virus. Current studies have confirmed that high-risk HPV can be detected in the cervical tissues of almost all cervical cancer patients, and the HPV infection rate in cervical cancer tissues of women in my country is greater than 95%. [0003] At present, there are preventive bivalent, quadrivalent and nine-valent vaccines in the world that can prevent 2, 4 and 9 types of human papillomavirus (HPV) infection respectively. However, there are more than 100 types of human papillomaviruses, and different types cause different clinical manifestations, and the prevalence of human papi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K16/08A61M31/00A61K39/42A61P31/20
CPCA61K2039/505A61M31/00A61M2210/1475A61P31/20C07K16/084A61M2210/005
Inventor 刁波琼周翔李胜华
Owner HUAKE TONGJI STEM CELL GENETIC ENG CO LTD
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