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Application of disulfide bond compounds in prevention and treatment of microbial diseases

A compound and disulfide bond technology, applied in the field of medicinal chemistry, can solve problems such as human hazards, and achieve the effects of not easy to produce resistance, strong bactericidal activity, and wide bactericidal spectrum

Pending Publication Date: 2021-02-23
LANZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Candida albicans (commonly known as Candida albicans) is an important conditional pathogenic fungus, which usually exists in the oral cavity, upper respiratory tract, intestinal tract and vagina of normal people. It is generally small in number in normal organisms and does not cause disease. However, when the immune function or general defense of the body is reduced or the structure of the normal flora is out of balance, it will turn into a pathogenic bacteria and cause harm to the human body.

Method used

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  • Application of disulfide bond compounds in prevention and treatment of microbial diseases
  • Application of disulfide bond compounds in prevention and treatment of microbial diseases
  • Application of disulfide bond compounds in prevention and treatment of microbial diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Example 1: Compounds 1-18 were all isolated and their structures identified were consistent with those reported in literature.

[0012] 2,2'-dithiodipyridine (1) CAS: 2127-03-9, purity >98%; dibenzothiazole disulfide (2) CAS: 120-78-5, purity >98%; dibenzyl Disulfide (3) CAS: 150-60-7, purity >98%; 3,3',5,5'-tetrachlorodiphenyl disulfide (4) CAS: 137897-99-5, purity >99% ; Dipropyl disulfide (5) CAS: 629-19-6, purity > 99%; a-lipoic acid (6) CAS: 1077-28-7, purity > 99%; Diphenyl disulfide (7) CAS: 882-33-7, purity >99%; 2,2'-difluorodiphenyl disulfide (8) CAS: 14135-38-7, purity >98%; 4,4'-dimethoxy Diphenyl disulfide (9) CAS: 5335-87-5, purity >98%; 4,4'-bipyridyl disulfide (10) CAS: 2645-22-9, purity >98%; 3,3' - Dihydroxydiphenyl disulfide (11) CAS: 21101-56-4, purity > 98%; Bis(2-thienyl) disulfide (12) CAS: 6911-51-9, purity > 95%; Isopropyl disulfide (13) CAS: 4253-89-8, purity > 98%; Difurfuryl disulfide (14) CAS: 4437-20-1, purity > 95%; Diethyl disulfide (1...

Embodiment 2

[0013] Embodiment 2: Determination and result of indoor antifungal activity

[0014] The phytopathogenic fungi used in this experiment are laboratory-preserved strains, and the medium used is potato agar dextrose medium (abbreviated as PDA) and YPG medium.

[0015] PDA medium formula: potato (peeled) 200g, glucose 20g, agar 15g, distilled water 1000mL, natural pH.

[0016] PDA medium configuration method: wash and peel the potatoes, weigh 200g and cut them into small pieces, boil them in distilled water for about 20 minutes (the potato pieces are soft but not rotten), filter with eight layers of gauze, make up the filtrate to 1000mL with distilled water, add 15g of agar , 20g of glucose, stirred to fully dissolve, then packed in Erlenmeyer flasks, sterilized at 121°C for 20 minutes, cooled for later use.

[0017] YPG medium formula: agar 20g, glucose 5g, peptone 5g, yeast extract 5g, distilled water 1000mL, natural pH.

[0018] Preparation method of YPG medium: After adding ...

Embodiment 3

[0031] Embodiment 3: Determination of bacteriostasis activity and result of plant pathogenic bacteria and human pathogenic bacteria indoor

[0032] The phytopathogenic bacteria used in this experiment were strains preserved at -80°C in the laboratory, and the MIC value was determined by the double dilution method. Nutrient broth medium (MH for short) is used for plant pathogenic bacteria used in the laboratory, and YEPD medium is used for human-derived pathogenic bacteria.

[0033] MH medium formula: MH broth powder 21g, distilled water 1000mL, natural pH.

[0034] Preparation method of MH medium: Weigh 21g of MH broth powder into 1000mL of distilled water, stir to dissolve it fully, then divide it into Erlenmeyer flasks, sterilize at 121°C for 20 minutes, and cool down for later use.

[0035] YEPD medium formula: yeast extract 10g, peptone 20g, glucose 20g, 2mg / mL chloramphenicol aqueous solution, natural pH.

[0036] YEPD medium preparation formula: Weigh 10g of yeast extr...

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Abstract

The invention belongs to the field of medicinal chemistry, and discloses application of disulfide bond compounds in prevention and treatment of diseases caused by sclerotinia sclerotiorum, rhizoctoniasolani, botrytis cinerea, fusarium graminearum, cotton fusarium oxysporum, magnaporthe grisea, aspergillus flavus, aspergillus niger, citrus canker, potato phytophthora parasitica, escherichia coli and candida albicans. A part of the compounds show a high inhibition effect and can be used for developing bactericidal lead compounds.

Description

technical field [0001] The invention belongs to the field of medicinal chemistry, and discloses a new application of a disulfide bond compound, in particular to its use in the prevention and treatment of Sclerotinia sclerotiorum, Rhizoctonia solani, Botrytis cinerea, Wheat scab, Cotton wilt, rice blast fungus, Aspergillus flavus, Aspergillus niger, canker citrus, potato blackleg, Escherichia coli, and Candida albicans. Background technique [0002] Over the past seven decades, rice production in China has gradually shifted northward due to the emergence of new arable land due to rising temperatures. Also due to climate change, corn farmers in the American Midwest are adopting new farming practices, including crop diversification, agricultural intensification and even abandoning corn cultivation. Pathogens and pests are the leading causes of crop loss, estimated to cause an average global loss of between 17.2% and 30.0% of major crops. In addition, around a quarter of the w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N43/40A01N43/78A01N41/12A01N43/26A01N43/10A01N43/08A01P1/00A01P3/00
CPCA01N41/12A01N43/08A01N43/10A01N43/26A01N43/40A01N43/78
Inventor 刘映前赵文斌张智军贺颖慧李虎杜莎莎吴天琳杨程杰燕银芳
Owner LANZHOU UNIVERSITY
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