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Antibacterial hydrogel dressing containing imidazolium bromide and preparation method and application of antibacterial hydrogel dressing

An antibacterial water and hydrogel technology, applied in the fields of polymer materials and biological materials, can solve the problems of single hydrogel performance and no antibacterial function, and achieve good biocompatibility and antibacterial performance, good bactericidal activity, Experiment with simple effects

Active Publication Date: 2019-03-26
DALIAN POLYTECHNIC UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the performance of traditional hydrogels is relatively single, and generally do not have antibacterial functions and other functions that promote tissue growth. Therefore, it is necessary to functionalize hydrogels and endow them with more functions that are beneficial to wound healing.

Method used

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  • Antibacterial hydrogel dressing containing imidazolium bromide and preparation method and application of antibacterial hydrogel dressing
  • Antibacterial hydrogel dressing containing imidazolium bromide and preparation method and application of antibacterial hydrogel dressing
  • Antibacterial hydrogel dressing containing imidazolium bromide and preparation method and application of antibacterial hydrogel dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] (1) Weigh 10g of polyvinyl alcohol (PVA), pour it into a three-necked flask, add 90ml of distilled water, take a constant temperature water bath at 100°C for 3 hours, stir at high speed to dissolve the PVA, and obtain a 10% PVA solution;

[0039] (2) 5g of acrylamide was added to 15mL of deionized water, then 0.2g of initiator ammonium persulfate was added, and nitrogen gas was introduced for 5 minutes to remove oxygen in the solution and prevent the chemical substances in the reaction solution from reacting with oxygen to obtain a mixed solution;

[0040] (3) Take 25g of 10% PVA solution, add 20g of the mixed solution in step (2), stir evenly, and then use an ultrasonic instrument to sonicate for 30min at 45HZ;

[0041] (4) The mixed solution of step (3) was heated at 70° C. for 30 minutes;

[0042] (5) The solution in (4) was subjected to cyclic freezing-thawing, specifically: freezing at -20°C for 12 hours and thawing at 20°C for 3 hours. The freezing-thawing process...

Embodiment 2

[0044] (1) Weigh 10g of PVA, pour it into a three-necked flask, add 90ml of distilled water, take a constant temperature water bath at 100°C for 3 hours, stir at a high speed to dissolve the PVA, and obtain a 10% PVA solution;

[0045] (2) Add 5g of acrylamide and 5g of 1-vinyl-3-butylimidazolium bromide into 15mL of deionized water, then add 0.2g of initiator ammonium persulfate, and pass nitrogen gas for 5 minutes to remove oxygen in the solution and prevent the reaction liquid from The chemical substance in the medium reacts with oxygen to obtain a mixed solution;

[0046] (3) Take 50 g of 10% PVA solution, add 12.3 g of the mixed solution in step (2), stir evenly, and then use an ultrasonic instrument to sonicate for 30 min at 45 Hz;

[0047] (4) The mixed solution of step (3) was heated at 70° C. for 30 minutes;

[0048] (5) The solution of (4) is subjected to cycle freezing-thawing, freezing at -20°C for 12h, and thawing at 20°C for 3h, the freezing-thawing process is rep...

Embodiment 3

[0051] (1) Weigh 10g of PVA, pour it into a three-necked flask, add 90ml of distilled water, take a constant temperature water bath at 100°C for 3 hours, stir at a high speed to dissolve the PVA, and obtain a 10% PVA solution;

[0052] (2) Add 5g of acrylamide and 5g of 1-vinyl-3-butylimidazolium bromide into 15mL of deionized water, then add 0.2g of initiator ammonium persulfate, and pass nitrogen gas for 5min to obtain a mixed solution;

[0053] (3) Take 50 g of 10% PVA solution, add 6.5 g of the mixed solution in step (2), and stir evenly. Then, sonicate for 30 minutes under the condition of 45HZ with an ultrasonic instrument.

[0054] (4) The mixed solution of step (3) was heated at 70° C. for 30 minutes;

[0055] (5) The solution of (4) is subjected to cycle freezing-thawing, freezing at -20°C for 12h, and thawing at 20°C for 3h, the freezing-thawing process is repeated 6 times to obtain an antibacterial hydrogel dressing containing imidazolium bromide .

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Abstract

The invention discloses an antibacterial hydrogel dressing containing imidazolium bromide and a preparation method and application of the antibacterial hydrogel dressing. Antibacterial components, acrylamide and an initiator are composited to form a linear polymer; then the linear polymer is evenly dispersed into a gel carrier system with good biocompatibility; and through heating at the appropriate temperature and the repeated freezing-unfreezing process, the antibacterial hydrogel dressing containing the imidazolium bromide is prepared. The antibacterial hydrogel dressing has a unique three-dimensional network structure with the large water content, the antibacterial effective components and matrix macromolecules can be tightly combined together through chemical bonds, and the situationthat due to component losing, pollution to the surrounding environment is caused, or harm to body health is caused is avoided; and the hydrogel dressing has the good biocompatibility, antibacterial property, mechanical property and environmental friendliness, and will have the very wide application prospects in the field of biological dressings and medical dressings.

Description

technical field [0001] The invention belongs to the fields of biological materials, polymer materials and the like, and relates to an antibacterial hydrogel dressing applied to promote wound healing and prevent wound infection, a preparation method and application thereof. Background technique [0002] With the development of biomedicine and material technology, higher requirements are put forward for medical dressings. Functional medical dressings with high moisture retention and antibacterial properties play an important role during treatment as a temporary skin substitute. When the skin tissue is traumatized, such as burns, abrasions, ulcers, etc., the resistance of the surface cells decreases, and Gram bacteria such as Staphylococcus aureus and Escherichia coli easily multiply on the wound, causing further expansion of the wound. Once a wound is infected by bacteria, it is not easy to heal. The dressings currently used are mainly gauze, which has poor water absorption ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00C08F261/04C08F220/56C08F251/00
CPCA61L26/0066A61L26/008A61L26/0085A61L26/0095A61L2300/216A61L2300/404C08F251/00C08F261/04C08L5/08C08L5/04C08F220/56C08L29/04
Inventor 李尧房换费旭田晶徐龙权
Owner DALIAN POLYTECHNIC UNIVERSITY
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