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Bifidobacterium longum SF-B-27 and application thereof

A technology of SF-B-27 and Lactobacillus bifidus, applied in the field of microorganisms, can solve the problems of increasing sleep time, high adhesion, etc., and achieve the effects of increasing sleep time, high adhesion, and relieving mental fatigue

Active Publication Date: 2021-02-19
山东向日葵生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the technical problem that the existing technology lacks products for improving sleep quality that do not cause drug dependence or adverse reactions, the present invention provides a strain of Lactobacillus longum SF-B-27 and its application, Lactobacillus longum SF-B -27 has high adhesion and strong gastrointestinal adaptability, providing a sleep-improving product that can significantly relieve sleep problems and increase sleep time

Method used

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  • Bifidobacterium longum SF-B-27 and application thereof
  • Bifidobacterium longum SF-B-27 and application thereof
  • Bifidobacterium longum SF-B-27 and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] The isolation and identification of embodiment 1 Bifidobacterium longum SF-B-27

[0040] 1. Bacterial source

[0041] Healthy baby poo.

[0042] 2. Isolation of strains

[0043] Do a ten-fold gradient dilution of healthy infant feces samples, and take 100 μL of each gradient and evenly spread it on the MRS solid plate medium, then take it out and place it in an anaerobic tank, and culture it overnight at 37°C;

[0044] MRS solid plate medium includes the following components:

[0045] Peptone 10g, beef powder 5g, yeast powder 4g, K 2 HPO 4 ·7H 2 O2g, triammonium citrate 2g, glucose 20g, CH 3 COONa·3H 2 O5g, MgSO 4 ·7H 2 O0.2g, MnSO 4 4H 2 O 0.05g, Tween 801mL, distilled water 1000mL;

[0046] On the next day, colonies of various shapes and sizes could be seen growing on the plate, and some characteristic colonies of lactic acid bacteria were picked for second-generation streak purification, and the plate was anaerobically activated for 1 day to obtain cultur...

Embodiment 2

[0057] Example 2 A product rich in sleep improvement of Bifidobacterium longum SF-B-27

[0058] A sleep-improving product rich in Bifidobacterium longum SF-B-27, the product contains Bifidobacterium longum SF-B-27, red date powder, astragalus powder, Codonopsis powder, Gastrodia elata powder, and isomaltooligosaccharides. The content of Mycobacterium SF-B-27 was 20 billion / g.

[0059] The preparation method of product comprises the following steps:

[0060] (1) Inoculate Bifidobacterium longum SF-B-27 into the MRS medium plate, the inoculation amount is 1%, after culturing at 37°C, the MRS bacterial liquid is centrifuged and vacuum freeze-dried to obtain bacterial powder;

[0061] (2) The auxiliary materials are mixed with jujube powder, astragalus powder, codonopsis powder, gastrodia elata powder, and isomaltooligosaccharide in a ratio of 1:1:1:1:1 to obtain the product.

[0062] (3) Mix the Bifidobacterium longum SF-B-27 bacteria powder prepared in step (1) with the auxili...

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PUM

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Abstract

The invention relates to the technical field of microorganisms, in particular to bifidobacterium longum SF-B-27 and application thereof. The preservation number of the bifidobacterium longum is CGMCCNo. 20925; The bifidobacterium longum SF-B-27 has high adhesion and strong gastrointestinal adaptability, and can obviously relieve the sleep problem and prolong the sleep time; and according to a product, containing the bifidobacterium longum SF-B-27 powder, for improving sleep, by adjusting tryptophan and serotonin secretion amount, central neurasthenia, insomnia and other symptoms can be relieved, mental fatigue is relieved, anxiety and depression symptoms are inhibited, and the intestinal flora balance can be adjusted.

Description

technical field [0001] The invention relates to the technical field of microorganisms, in particular to a strain of Lactobacillus longum SF-B-27 and its application. Background technique [0002] According to the definition in the "Guidelines for the Diagnosis and Treatment of Insomnia in Adults in China", insomnia refers to a subjective experience of patients who are not satisfied with sleep time and (or) quality and affect daytime social function. The common symptoms of insomnia are difficulty in falling asleep, decreased sleep quality and reduced sleep time, decreased memory and attention. With the development of society, people are under more and more pressure in work and life. Due to factors such as people's living habits and living environment, sleep is affected, which directly leads to lack of sleep. Currently, nearly 3 billion people in the world suffer from insomnia. , my country also has 600 million people who suffer from insomnia, and insomnia has become a huge hi...

Claims

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Application Information

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IPC IPC(8): C12N1/20A61K35/745A61K36/8988A61P1/00A61P25/20A61P25/22A61P25/24C12R1/01A61K31/702
CPCA61K35/745A61P25/20A61P25/22A61P25/24A61P1/00A61K36/725A61K36/481A61K36/344A61K36/8988A61K31/702A61K36/815C12R2001/01C12N1/205A61K2300/00
Inventor 夏越马明磊刘连军耿苗苗韩文立夏超凡
Owner 山东向日葵生物工程有限公司
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