Preparation method of double-layer composite film

Abstract

The invention discloses a preparation method of a double-layer composite film. According to the method, a low-power electron beam deposition technology is adopted for a bottom layer to prepare a polylactic acid-based ciprofloxacin antibacterial film, and an ultrasonic atomization method is adopted for an upper layer to prepare a PU: paraffin: vancomycin antibacterial composite film. The prepared antibacterial film is high in binding force with a substrate, good in compactness, controllable in film thickness, good in antibacterial performance and excellent in slow release performance, the slowrelease antibacterial effect can reach at least one week, the slow release antibacterial performance is stable, and the antibacterial film can be used for surface antibiosis and bacterial adhesion elimination of medical instruments.

Description

technical field [0001] The invention belongs to the technical field of preparation of antibacterial films, and relates to a preparation method of PLA: ciprofloxacin / PU: paraffin: vancomycin double-layer composite film. Background technique [0002] Polyurethane (PU) is a class of polymers containing carbamate groups (—NHCOO—) on the main chain of the polymer structure, usually by stepwise addition polymerization of polyisocyanates, polyol polymers or aromatic diamines made. Since polyurethane contains strong polar carbamate groups, different thermosetting polyurethane and thermoplastic polyurethane products can be prepared by adjusting the ratio of NCO / OH. Polyurethane not only has good biocompatibility, biodegradation, biostability, anticoagulation, and antibacterial properties, but also has excellent mechanical properties, wear resistance, and easy processing and molding applications. It is used in artificial heart valves, blood vessels, etc. Many biomedical fields such ...

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Problems solved by technology

[0007] Li Kuankuan et al prepared injectable polyurethane-based composites by adding inorganic antibacterial agents silver phosphate and nano-hydroxyapatite to in-situ cured polyurethane. Reaching 24 hours, the antibacterial persistence is poor, and Ag is a heavy metal element. If it is used in the medical field, it has unpredictable risks (Li Kuankuan, Zuo Yi, Jiang Jiaxing, etc. Preparation and characterization of injectable polyurethane-based antibacterial composite bone cement[J ].Chemical Research and Application, 2016,28(5):748-752)

Zhang Jingzhe et al. used mesoporous hydroxyapatite / chitosan as the sustained-release carrier of vancomycin. Although it has a certain osteoinductive effect, the drug loading capacity is limited and the drug concentration cannot be maintained continuously (Zhang Jingzhe, Li Dongdong, Liu Guifeng, etc. New Type Preparation of Mesoporous Hydroxyapatite / Chitosan-Vancomycin Drug Delivery System Composite and Its In Vitro Antibacterial and Osteogenesis[J]. Chemical Journal of Chinese Universities, 2012,33(2):219-224.)

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