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Intestinal flora capsule as well as preparation method and application thereof

A technology of intestinal flora and capsules, which is applied in capsule delivery, pharmaceutical formulations, and medical raw materials derived from bacteria, etc. It can solve the problems of people who are difficult to accept transplants, the research on flora transplantation technology is not in-depth, and there is a lack of efficient transplantation methods.

Pending Publication Date: 2021-02-09
深圳市融思生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the in-depth research on flora transplantation technology, there is still a lack of a standard high-efficiency transplantation method
However, most of the existing flora transplantation methods use fecal flora for enema, which requires professional personnel and equipment, and is difficult to accept for transplanted people, and the colonization of flora is low.

Method used

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  • Intestinal flora capsule as well as preparation method and application thereof
  • Intestinal flora capsule as well as preparation method and application thereof
  • Intestinal flora capsule as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] In the present example, the intestinal flora capsule contains the lyophilized powder of the intestinal flora, which is made by mixing the intestinal flora and the preparation auxiliary liquid and freeze-drying. The specific preparation steps are as follows:

[0081] (1) Sample acquisition and transportation: about 400 g of feces samples were collected from the feces provider, put into a sealed bag and vacuum-sealed, and the sealed feces samples were put into a dry ice incubator and stored at -15°C to -20°C. Temporarily stored in the environment, transported to the laboratory for processing within 6 hours;

[0082] (2) Dilution and mixing: in the anaerobic workbench, add 3600mL sterile saline solution containing 0.9% sodium chloride to the collected feces samples, use a magnetic stirrer to stir and mix, the rotating speed is 500RPM, and the time is 30min, to obtain Stool sample dilution mixture;

[0083] (3) Preliminary centrifugation: Preliminary centrifugation was per...

Embodiment 2

[0089] In the present example, the intestinal flora capsule contains the lyophilized powder of the intestinal flora, which is made by mixing the intestinal flora and the preparation auxiliary liquid and freeze-drying. The specific preparation steps are as follows:

[0090] (1) Sample acquisition and transportation: about 400 g of feces samples were collected from the feces provider, put into a sealed bag and vacuum-sealed, and the sealed feces samples were put into a dry ice incubator and stored at -15°C to -20°C. Temporarily stored in the environment, transported to the laboratory for processing within 6 hours;

[0091] (2) Dilution and mixing: in the anaerobic workbench, add 3600mL sterile saline solution containing 0.9% sodium chloride to the collected feces samples, use a magnetic stirrer to stir and mix, the rotating speed is 500RPM, and the time is 30min, to obtain Stool sample dilution mixture;

[0092] (3) Preliminary centrifugation: Preliminary centrifugation was per...

Embodiment 3

[0098] In the present example, the intestinal flora capsule contains the lyophilized powder of the intestinal flora, which is made by mixing the intestinal flora and the preparation auxiliary liquid and freeze-drying. The specific preparation steps are as follows:

[0099] (1) Sample acquisition and transportation: about 400 g of feces samples were collected from the feces provider, put into a sealed bag and vacuum-sealed, and the sealed feces samples were put into a dry ice incubator and stored at -15°C to -20°C. Temporarily stored in the environment, transported to the laboratory for processing within 6 hours;

[0100] (2) Dilution and mixing: in the anaerobic workbench, add 3600mL sterile saline solution containing 0.9% sodium chloride to the collected feces samples, use a magnetic stirrer to stir and mix, the rotating speed is 500RPM, and the time is 30min, to obtain Stool sample dilution mixture;

[0101] (3) Preliminary centrifugation: Preliminary centrifugation was per...

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Abstract

The invention relates to the technical field of medical preparations and processes, and particularly discloses an intestinal flora capsule as well as a preparation method and application thereof. Through excrement collection, flora extraction, preparation preparation, preparation filling and other technologies, intestinal flora is prepared into capsules in the form of freeze-dried powder, intestinal flora transplantation is performed by taking the capsules by a human body, and compared with an existing method, the method has the advantages of being safe, convenient, high in flora colonizationrate and the like. A preparation auxiliary liquid used during preparation of the intestinal flora capsule can effectively protect intestinal flora, reduce the influence of excrement on flora composition, improve the survival rate (more than 90%) of the intestinal flora in freeze-dried powder, and improve the colonization rate of the flora in intestinal tracts, and the obtained capsule can be stably stored in an environment of subzero 20 DEG C for a long time and is convenient for patients to take in daily life, and a new effective intestinal flora transplanting method is provided for maintaining the daily good mental state of the human body.

Description

technical field [0001] The invention relates to the technical field of medical preparations and techniques, and specifically discloses an intestinal flora capsule, a preparation method and application thereof. Background technique [0002] Scientific research has shown that there are many types and large numbers of intestinal microorganisms in the human body. The normal intestinal flora, as the natural barrier of the human body, plays an important role in maintaining human health. The intestinal flora of the human body will change with people's age, diet and other factors and maintain an overall balance. In some cases, when the balance of intestinal flora in the human body is disrupted, it will cause intestinal flora imbalance. For example, the large number of pathogenic bacteria in the human intestinal tract caused by external infections will negatively affect people's health and even cause diseases. [0003] The composition of the human gut microbiota has been shown to b...

Claims

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Application Information

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IPC IPC(8): A61K35/74A61K9/48A61K47/18A61K47/26A61K47/02A61K47/22A61K47/46A61P1/00A61P25/22C12N1/04
CPCA61K35/74A61K9/4891A61K9/4858A61K9/485A61K9/4875A61P1/00A61P25/22C12N1/04
Inventor 李晓政王振宇
Owner 深圳市融思生物科技有限公司
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