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Extraction process of high-purity ultralow-viscosity sodium alginate

A sodium alginate and extraction process technology, applied in the field of sodium alginate extraction process, can solve the problem of low purity and achieve the effect of simple operation and low energy consumption

Inactive Publication Date: 2021-02-05
青岛聚大洋藻业集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Application No. 201310326503.3 discloses a production process of pharmaceutical-grade sodium alginate, which includes soaking and washing-digestion-dilution-foaming and floating-filtering-calcification-decalcification-washing-pressing-neutralization and centrifugation-crushing and drying steps. When exogenous inorganic salts were added, other inorganic salts were also produced, but they were not removed very well, resulting in low purity

Method used

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  • Extraction process of high-purity ultralow-viscosity sodium alginate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] The first step, decalcification

[0053] Take 200g of 80-mesh sodium alginate, add 1% (w / v) hydrochloric acid 1000mL, soak for 1.5h, stir 4 times in the middle, dehydrate with 400-mesh filter, add 800mL of water, stir and wash once, and then dehydrate with 400-mesh filter to obtain Alginic acid;

[0054] The second step, degradation

[0055] Add 600mL of water to the alginic acid, add 50mL of 30% (w / v) and stir, put it in a 60°C water bath and heat it for degradation for 36h, take it out and put it at room temperature, dehydrate it with a 400-mesh mesh, and obtain the degraded dehydrated acid block;

[0056] The third step, neutralization

[0057] Add 95° ethanol at a ratio of 1:1 to the weight of alginic acid after dehydration and degradation, start stirring, add an appropriate amount of 25% (w / v) NaOH, and after neutralization for 2 hours, use an acidity meter to measure the pH of the ethanol between 7-7.5, 400 mesh net dehydration;

[0058] The fourth step, decol...

Embodiment 2

[0067] The first step, decalcification

[0068] Take 200g of 80-mesh sodium alginate, add 2000mL of 3.5% (w / v) hydrochloric acid, soak for 1.5h, stir 5 times in the middle, dehydrate with a 400-mesh filter, add 1000mL of water to stir and wash once, and then dehydrate with a 400-mesh filter to obtain Alginic acid;

[0069] The second step, degradation

[0070] Add 600mL of water to the alginic acid, add 50mL of 30% (w / v) and stir, put it in a 60°C water bath and heat it for degradation for 48h, take it out and put it at room temperature, dehydrate it with a 400-mesh mesh, and obtain the degraded dehydrated acid block;

[0071] The third step, neutralization

[0072] Add 95° ethanol at a ratio of 1:1 to the weight of alginic acid after dehydration and degradation, start stirring, add an appropriate amount of 30% (w / v) NaOH, neutralize for 2 hours, use an acidity meter to measure the pH of ethanol between 7-7.5, 400 mesh net dehydration;

[0073] The fourth step, decolorizat...

Embodiment 3

[0082] The first step, decalcification

[0083] Take 200g of 80-mesh sodium alginate, add 2000mL of 2% (w / v) hydrochloric acid, soak for 1.5h, stir 5 times in the middle, dehydrate with a 400-mesh filter, add 900mL of water to stir and wash once, and then dehydrate with a 400-mesh filter to obtain Alginic acid;

[0084] The second step, degradation

[0085] Add 600mL of water to the alginic acid, add 50mL of 30% (w / v) and stir, put it in a water bath at 80°C and heat it for degradation for 40h, take it out and let it cool to room temperature, and dehydrate it with a 400-mesh mesh to obtain the degraded dehydrated acid block;

[0086] The third step, neutralization

[0087] Add 95° ethanol at a ratio of 1:1 to the weight of alginic acid after dehydration and degradation, start stirring, add an appropriate amount of 28% (w / v) NaOH, neutralize for 2 hours, use an acidity meter to measure the pH of ethanol between 7-7.5, 400 mesh net dehydration;

[0088] The fourth step, deco...

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Abstract

The invention discloses an extraction process of high-purity ultralow-viscosity sodium alginate, which belongs to the technical field of sodium alginate extraction. The method sequentially comprises the following steps: decalcifying, degrading, neutralizing, decolorizing, dehydrating, crushing and drying to prepare the high-purity ultralow-viscosity sodium alginate. In the extraction process, calcium ions are directly removed by adopting an acid removal method in the decalcification step, the calcium ions are thoroughly removed by adopting the acid removal method without residues, and the purity is improved by adopting the acid removal method for decalcification; after the decalcification step, the viscosity of the sodium alginate can be reduced to 4mPa. S to 7mPa. S through cooperation ofmedium-high temperature and hydrogen peroxide degradation, and after the degradation is finished, the hydrogen peroxide is completely decomposed without residues; in the decolorization step, an activated carbon adsorption method is adopted, the activated carbon adsorption capacity is higher, and various water-insoluble substances and pigments can be effectively removed in cooperation with diatomite, so that a glue solution is colorless and transparent. According to the method, the high-purity (88% or above) ultralow-viscosity ( 4mPa. S to 7mPa. S) sodium alginate can be obtained.

Description

technical field [0001] The invention relates to an extraction process of sodium alginate, in particular to an extraction process of high-purity and ultra-low viscosity sodium alginate. Background technique [0002] Sodium alginate, also known as sodium alginate, kelp gum, alginate, is widely used in food, medicine, textile, printing and dyeing, papermaking, daily chemical products and other products. Sodium alginate is more and more widely used in the pharmaceutical industry, but there are still problems of high production cost and unstable product quality. [0003] The preparation method about sodium alginate in the prior art mainly contains: [0004] Application No. 200910256451.0 discloses a method for preparing high-purity sodium alginate. Alginic acid is neutralized and dissolved in water with sodium hydroxide solution. The concentration of sodium hydroxide solution is 5% to 50%. Minutes, the ratio of alginic acid to activated carbon is 6:1; suction filtration, the pr...

Claims

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Application Information

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IPC IPC(8): C08B37/04
CPCC08B37/0084C08B37/0003
Inventor 封凯吴仕鹏程跃谟于云霞
Owner 青岛聚大洋藻业集团有限公司
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