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Modified carboxymethyl chitosan microsphere as well as preparation method and application thereof

A technology of carboxymethyl chitosan microspheres and carboxymethyl chitosan, applied in application, medical science, surgery, etc., can solve the problems of limited application and development, weak drug action, low drug loading rate, etc. , to achieve the effect of increasing drug loading rate, facilitating structural stability, and uniform distribution of components

Active Publication Date: 2021-02-05
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, the preparation of drug-loaded microspheres using a single carboxymethyl chitosan as a raw material still has defects, mainly due to the lack of suitable drug-loading groups. The action force is not strong, so the drug loading rate is low, and the drug is easy to release suddenly, which limits its application and development

Method used

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  • Modified carboxymethyl chitosan microsphere as well as preparation method and application thereof
  • Modified carboxymethyl chitosan microsphere as well as preparation method and application thereof
  • Modified carboxymethyl chitosan microsphere as well as preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0033] 1) In a 250mL three-neck flask equipped with a reflux device, dissolve 20g of N-acryloyl taurine in 80mL of deionized water to make a solution, then add 0.6g of potassium persulfate, stir for 20 minutes, protect with nitrogen, and raise the temperature first React at 65°C for 4 hours, then raise the temperature to 70°C for 2 hours, precipitate and wash the polymer with absolute ethanol, and dry at constant temperature in vacuum until constant weight to obtain poly(N-acryloyl taurine);

[0034] 2) In a 100mL beaker, dissolve 2.0g of carboxymethyl chitosan in 50mL of deionized water, then add 1.2g of poly(N-acryloyl taurine) obtained in step 1) into the solution, stir and dissolve to obtain mixture;

[0035] 3) Add 200 mL of liquid paraffin to a 500 mL three-necked flask equipped with a mechanical stirring device, and add 3 g of emulsifier dodecyl dimethyl betaine to it, and after stirring for 30 minutes, pour the mixed solution obtained in step 2) into , stirred mechani...

Embodiment 2

[0037] Step 1), 3) are identical with embodiment 1; But in step 2), change the amount of poly(N-acryloyl taurine) to be 1.6 grams, all the other operating conditions are the same, obtain modified carboxymethyl chitosan Microspheres, sample label: CCS / NAT-2.

Embodiment 3

[0039] Step 1), 3) are identical with embodiment 1; But in step 2), change the amount of poly(N-acryloyl taurine) to be 2.0 grams, all the other operating conditions are the same, obtain modified carboxymethyl chitosan Microspheres, sample label: CCS / NAT-3.

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Abstract

The invention discloses a modified carboxymethyl chitosan microsphere as well as a preparation method and application thereof. The preparation method comprises the following steps of firstly, preparing poly(N-acryloyl taurine), then adding the poly(N-acryloyl taurine) into a carboxymethyl chitosan solution to form a mixed solution, and finally, preparing the carboxymethyl chitosan and poly(N-acryloyl taurine) interpenetrating network microsphere by a suspension crosslinking method. According to the preparation method provided by the invention, the poly(N-acryloyl taurine) is formed by polymerizing monomer N-acryloyl taurine; the density of sulfonic acid groups is relatively high; in a structural unit of the poly(N-acryloyl taurine), negative charge carried by the sulfonic acid groups of side chains interact with drug molecules with positive charge; and the groups are introduced into an embolism microsphere, so that the drug loading rate of the microsphere on an anti-cancer drug doxorubicin hydrochloride can be obviously improved.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a modified carboxymethyl chitosan microsphere and its preparation method and application. Background technique [0002] Embolization microspheres can be used in the treatment of advanced tumor diseases in interventional therapy. The drug-loaded embolization microspheres are directed to the arteries around the tumor tissue, which not only blocks the nutrient supply to the tumor tissue, but also releases anti-tumor drugs. The increase in the concentration of anticancer drugs inhibits tumor growth. [0003] Embolization microspheres include degradable and non-degradable types. The non-degradable embolization microspheres mainly include PVA microspheres, ethyl cellulose microspheres, etc. The microspheres can permanently block the diseased tissue. Degradable embolic microspheres include gelatin microspheres, albumin microspheres, polylactic acid microspheres...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/00A61L24/06A61L24/08
CPCA61L24/08A61L24/06A61L24/0015A61L24/0042A61L2300/23A61L2300/416C08L5/08C08L41/00
Inventor 张丽萍倪才华桑欣欣刘仁石刚
Owner JIANGNAN UNIV
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