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Compositions and methods using a nicotinamide adenine dinucleotide (nad+) precursor and at least one ketone or ketone precursor

A technology of nicotinamide adenine, dinucleotide, applied in the field of providing a treatment or prevention selected from the group consisting of the following items, capable of solving the problems of harmful effects, limited efficacy, no effect, etc., to maintain the heart Effects on health, improvement of concentration, and maintenance of muscle mass

Pending Publication Date: 2021-01-29
SOC DES PROD NESTLE SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the efficacy of these nutritional interventions is very limited and even controversial, with studies showing no or even detrimental effects

Method used

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  • Compositions and methods using a nicotinamide adenine dinucleotide (nad+) precursor and at least one ketone or ketone precursor
  • Compositions and methods using a nicotinamide adenine dinucleotide (nad+) precursor and at least one ketone or ketone precursor
  • Compositions and methods using a nicotinamide adenine dinucleotide (nad+) precursor and at least one ketone or ketone precursor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0074] The present disclosure provides NAD-containing + Compositions of precursors and at least one ketone or combination of ketone precursors (eg, ketoesters). In one embodiment, NAD + The precursor is selected from the group consisting of: tryptophan, niacin (Nicotinic Acid / Niacin), niacinamide (Nicotinamide / Niacinamide), nicotinamide riboside (NR), reduced nicotinamide riboside (NRH) , beta-nicotinamide mononucleotide (NMN), trigonelline (N-methylnicotinamide), niacin mononucleotide, niacin ribonucleoside, a food extract rich in at least one of these compounds substances, such as nicotinamide adenine dinucleotide (NAD)-rich food extracts, and mixtures thereof. As used herein, "nicotinamide riboside" includes the L-valine and L-phenylalanine esters of nicotinamide riboside.

[0075] In one embodiment, the at least one ketone or ketone precursor comprises medium chain triglycerides, wherein residues R1, R2 and R3 are independently 7 carbons, 8 carbons, 9 carbons or 10 carb...

Embodiment

[0104] The following non-limiting examples present scientific data that develop and support the inclusion of nicotinamide adenine dinucleotide (NAD + ) precursors and at least one ketone or combination of ketone precursors for the concept of cellular nutrition.

[0105] method

[0106] Differentiated human iPSC astrocytes were obtained from Cellular Dynamics International (CDI, Madison, WI, USA). Thaw the cells according to the manufacturer's instructions. iCell astrocytes were cultured in DMEM supplemented with 10% fetal bovine serum and N2 complement.

[0107] Oxygen consumption in human iPSC-derived astrocytes was measured in a Seahorse XF96 instrument (Seahorse Bioscience, North Billerica, MA, USA). Astrocytes were seeded directly into Seahorse 96-well tissue culture plates (XF96 FluxPaks #102416-100; Seahorse Biosciences) at a density of 40,000 cells / well. Cells were incubated with 0.5 mM nicotinamide riboside chloride (NR) or fresh medium for 24 hours prior to the ...

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Abstract

A composition can treat or prevent at least one physical state selected from the group consisting of oxidative stress, a condition associated with oxidative stress, a reduced level of glutathione, anda condition associated with a reduced level of glutathione. The composition contains an effective amount of a combination of a Nicotinamide Adenine Dinucleotide (NAD + ) precursor and at least one ketone or ketone precursor. The composition can be an enterally administered composition such as an orally administered food product or food supplement.

Description

Background technique [0001] The present disclosure generally relates to being able to treat or prevent oxidative stress, conditions associated with oxidative stress, reduced glutathione levels, conditions associated with reduced glutathione levels, reduced redox ratio NAD + / NADH, or NAD with a lower redox ratio + Compositions and methods for NADH-associated disorders. Alternatively or in addition, the compositions and methods improve exercise capacity and physical function. [0002] Over the past few decades, the prevalence of obesity has risen to epidemic proportions worldwide. Approximately 1 billion people worldwide are overweight or obese, and these conditions increase mortality, mobility costs, and economic costs. Obesity occurs when energy intake exceeds energy expenditure, and the excess energy is stored primarily as fat in adipose tissue. Weight loss and prevention of weight gain can be achieved by reducing energy intake or bioavailability, increasing energy expen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/19A61K31/405A61K31/4425A61K31/455A61K31/706A61P25/28
CPCA61K31/19A61K31/405A61K31/4425A61K31/455A61K31/706A61P25/28A61K2300/00A23L33/125A23L33/40A23V2002/00A61K9/0056A61K31/121
Inventor B·屈埃努I·C·塞维林
Owner SOC DES PROD NESTLE SA
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